| 2021-01-24 | AltachvSalzburgBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2021-01-24 | PAOKvAEKSuper League · Greece | 2–2 | Super League · Greece |
| 2021-01-24 | MoreirensevPortimonensePrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-01-24 | Las PalmasvLeganesLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-01-24 | BesiktasvGoztepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-01-24 | MetzvNantesLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-01-24 | St PaulivRegensburg2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-01-24 | SantosvGoiasSerie A · Brazil | 3–4 | Serie A · Brazil |
| 2021-01-24 | Athletico-PRvFlamengo RJSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-01-24 | Sport RecifevBahiaSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-01-23 | SevillavCadizLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-01-23 | MechelenvEupenPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-01-23 | AberdeenvMotherwellPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-01-23 | StockportvBoreham WoodNational League · England | 1–1 | National League · England |
| 2021-01-23 | VeneziavCittadellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-01-23 | Asteras TripolisvLarisaSuper League · Greece | 1–0 | Super League · Greece |
| 2021-01-23 | KortrijkvCercle BruggePro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-01-23 | PueblavClub TijuanaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-01-23 | BraunschweigvHamburg2. Bundesliga · Germany | 2–4 | 2. Bundesliga · Germany |
| 2021-01-23 | CaenvRodezLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-01-23 | Dag and RedvKings LynnNational League · England | 3–2 | National League · England |
| 2021-01-23 | LugovTenerifeLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-01-23 | Aston VillavNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-01-23 | ScunthorpevGrimsbyLeague Two · England | 3–0 | League Two · England |
| 2021-01-23 | BielefeldvEin FrankfurtBundesliga · Germany | 1–5 | Bundesliga · Germany |
| 2021-01-23 | GenclerbirligivTrabzonsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-01-23 | SalernitanavPescaraSerie B · Italy | 2–0 | Serie B · Italy |
| 2021-01-23 | Dover AthleticvSolihullNational League · England | 0–2 | National League · England |
| 2021-01-23 | SouthendvMansfieldLeague Two · England | 0–1 | League Two · England |
| 2021-01-23 | CambridgevBradfordLeague Two · England | 0–0 | League Two · England |
| 2021-01-23 | ChateaurouxvValenciennesLigue 2 · France | 3–3 | Ligue 2 · France |
| 2021-01-23 | FiorentinavCrotoneSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-01-23 | WeymouthvHartlepoolNational League · England | 1–0 | National League · England |
| 2021-01-23 | Leyton OrientvForest GreenLeague Two · England | 0–1 | League Two · England |
| 2021-01-23 | DunkerquevAjaccioLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-01-23 | TranmerevBoltonLeague Two · England | 2–1 | League Two · England |
| 2021-01-23 | MorecambevColchesterLeague Two · England | 3–0 | League Two · England |
| 2021-01-23 | PortsmouthvHullLeague One · England | 0–4 | League One · England |
| 2021-01-23 | ChesterfieldvWrexhamNational League · England | 2–1 | National League · England |
| 2021-01-23 | FreiburgvStuttgartBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-01-23 | PSV EindhovenvWaalwijkEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2021-01-23 | LensvNiceLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-01-23 | ApollonvArisSuper League · Greece | 0–1 | Super League · Greece |
| 2021-01-23 | UdinesevInterSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-01-23 | Sao PaulovCoritibaSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-01-23 | AlavesvReal MadridLa Liga · Spain | 1–4 | La Liga · Spain |
| 2021-01-23 | NancyvNiortLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-01-23 | SociedadvBetisLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-01-23 | LincolnvNorthamptonLeague One · England | 2–1 | League One · England |
| 2021-01-23 | BromleyvHalifaxNational League · England | 1–2 | National League · England |