| 2021-11-27 | BoltonvCheltenhamLeague One · England | 2–2 | League One · England |
| 2021-11-27 | BragantinovAmerica MGBrasileirão · Brazil | 1–1 | Brasileirão · Brazil |
| 2021-11-27 | Holstein KielvWerder Bremen2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-11-27 | ApollonvLamiaSuper League Greece · Greece | 0–0 | Super League Greece · Greece |
| 2021-11-27 | Vissel KobevYokohama F. MarinosJ1 League · Japan | 0–2 | J1 League · Japan |
| 2021-11-27 | BournemouthvCoventryChampionship · England | 2–2 | Championship · England |
| 2021-11-27 | Erzgebirge AuevDarmstadt2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-11-27 | ShrewsburyvCharltonLeague One · England | 1–0 | League One · England |
| 2021-11-27 | SampdoriavVeronaSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-11-27 | SwindonvHarrogateLeague Two · England | 1–1 | League Two · England |
| 2021-11-27 | BeneventovRegginaSerie B · Italy | 4–0 | Serie B · Italy |
| 2021-11-27 | KhimkivKrasnodarRussian Premier League · Russia | 3–3 | Russian Premier League · Russia |
| 2021-11-27 | FamalicaovPortimonensePrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-11-27 | DundeevMotherwellPremiership · Scotland | 3–0 | Premiership · Scotland |
| 2021-11-27 | LincolnvAccringtonLeague One · England | 0–1 | League One · England |
| 2021-11-27 | MorecambevMilton Keynes DonsLeague One · England | 0–4 | League One · England |
| 2021-11-27 | RakowvZaglebieEkstraklasa · Poland | 4–0 | Ekstraklasa · Poland |
| 2021-11-27 | GillinghamvPortsmouthLeague One · England | 0–1 | League One · England |
| 2021-11-27 | OddvValerengaEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-11-27 | AroucavBoavistaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-11-27 | Sheffield WedsvWycombeLeague One · England | 2–2 | League One · England |
| 2021-11-27 | BelenensesvBenficaPrimeira Liga · Portugal | 0–7 | Primeira Liga · Portugal |
| 2021-11-27 | Willem IIvGo Ahead EaglesEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-11-27 | SionvSt. GallenSwiss Super League · Switzerland | 3–1 | Swiss Super League · Switzerland |
| 2021-11-27 | EupenvKortrijkPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-11-27 | JuventusvAtalantaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-11-27 | Kings LynnvAldershotNational League · England | 0–1 | National League · England |
| 2021-11-27 | Kashima AntlersvSagan TosuJ1 League · Japan | 1–0 | J1 League · Japan |
| 2021-11-27 | MallorcavGetafeLaLiga · Spain | 0–0 | LaLiga · Spain |
| 2021-11-27 | NorwichvWolvesPremier League · England | 0–0 | Premier League · England |
| 2021-11-27 | TorquayvHalifaxNational League · England | 2–3 | National League · England |
| 2021-11-27 | St JohnstonevHibernianPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-11-27 | LillevNantesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-11-27 | ZwollevWaalwijkEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-11-27 | CharleroivAnderlechtPro League · Belgium | 1–3 | Pro League · Belgium |
| 2021-11-27 | Oita TrinitavYokohama FCJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-11-27 | Shonan BellmarevTokushimaJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-11-27 | ArsenalvNewcastlePremier League · England | 2–0 | Premier League · England |
| 2021-11-27 | BurgosvMalagaLaLiga 2 · Spain | 3–0 | LaLiga 2 · Spain |
| 2021-11-27 | Sepsi Sf. GheorghevChindia TargovisteLiga I · Romania | 0–0 | Liga I · Romania |
| 2021-11-26 | Ad. DemirsporvKasimpasaSüper Lig · Türkiye | 0–0 | Süper Lig · Türkiye |
| 2021-11-26 | CagliarivSalernitanaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-11-26 | MoreirensevGil VicentePrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-11-26 | Ath BilbaovGranadaLaLiga · Spain | 2–2 | LaLiga · Spain |
| 2021-11-26 | ColchestervNewport CountyLeague Two · England | 1–1 | League Two · England |
| 2021-11-26 | LeccevTernanaSerie B · Italy | 3–3 | Serie B · Italy |
| 2021-11-26 | WaterfordvUC DublinLeague of Ireland Premier Division · Republic of Ireland | 1–2 | League of Ireland Premier Division · Republic of Ireland |
| 2021-11-26 | West BromvNott'm ForestChampionship · England | 0–0 | Championship · England |
| 2021-11-26 | BuyuksehyrvAltaySüper Lig · Türkiye | 0–0 | Süper Lig · Türkiye |
| 2021-11-26 | MirandesvOviedoLaLiga 2 · Spain | 1–1 | LaLiga 2 · Spain |