| 2021-01-24 | AtromitosvOlympiakosSuper League · Greece | 0–1 | Super League · Greece |
| 2021-01-24 | Gaz Metan MediasvPoli IasiSuperliga · Romania | 2–1 | Superliga · Romania |
| 2021-01-24 | ElchevBarcelonaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-01-24 | Schalke 04vBayern MunichBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2021-01-24 | RennesvLilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-01-24 | AtlasvTigres UANLLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-01-24 | VeronavNapoliSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-01-24 | GenoavCagliariSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-01-24 | CearavPalmeirasSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-01-24 | HoffenheimvFC KolnBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-01-24 | OsasunavGranadaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-01-24 | Ath MadridvValenciaLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-01-24 | St EtiennevLyonLigue 1 · France | 0–5 | Ligue 1 · France |
| 2021-01-24 | PrestonvReadingChampionship · England | 0–0 | Championship · England |
| 2021-01-24 | CastellonvSp GijonLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-01-24 | PanetolikosvLamiaSuper League · Greece | 0–0 | Super League · Greece |
| 2021-01-24 | GianninavVolos NFCSuper League · Greece | 0–1 | Super League · Greece |
| 2021-01-24 | DenizlisporvKaragumrukSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-01-24 | CeltavEibarLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-01-24 | MaritimovPacos FerreiraPrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2021-01-24 | Atletico GOvFortalezaSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-01-24 | FamalicaovGuimaraesPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-01-24 | GaziantepvHataysporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-01-24 | LeccevEmpoliSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-01-24 | ReimsvBrestLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-01-24 | AlmeriavSabadellLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2021-01-24 | Yeni MalatyasporvGalatasaraySüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-01-24 | BordeauxvAngersLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-01-24 | TwentevVVV VenloEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-01-24 | LaziovSassuoloSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-01-24 | St. GallenvLuganoSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2021-01-24 | SandhausenvBochum2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-01-24 | MiddlesbroughvBlackburnChampionship · England | 0–1 | Championship · England |
| 2021-01-24 | CremonesevSpalSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-01-24 | VascovAtletico-MGSerie A · Brazil | 3–2 | Serie A · Brazil |
| 2021-01-24 | Club BruggevGenkPro League · Belgium | 3–2 | Pro League · Belgium |
| 2021-01-24 | Oud-Heverlee LeuvenvGentPro League · Belgium | 0–3 | Pro League · Belgium |
| 2021-01-24 | LogronesvOviedoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2021-01-24 | UtrechtvSparta RotterdamEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-01-24 | DarmstadtvHolstein Kiel2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2021-01-24 | FC BotosanivDin. BucurestiSuperliga · Romania | 4–0 | Superliga · Romania |
| 2021-01-24 | InternacionalvGremioSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-01-24 | LASKvTirolBundesliga · Austria | 2–4 | Bundesliga · Austria |
| 2021-01-24 | WaregemvBeerschot VAPro League · Belgium | 0–3 | Pro League · Belgium |
| 2021-01-24 | FeyenoordvAZ AlkmaarEredivisie · Netherlands | 2–3 | Eredivisie · Netherlands |
| 2021-01-24 | TolucavNecaxaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-01-24 | ParmavSampdoriaSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-01-24 | FluminensevBotafogo RJSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-01-24 | KonyasporvAntalyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-01-24 | StandardvCharleroiPro League · Belgium | 3–2 | Pro League · Belgium |