| 2021-01-30 | RB LeipzigvLeverkusenBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-01-30 | HartbergvSalzburgAustrian Bundesliga · Austria | 0–3 | Austrian Bundesliga · Austria |
| 2021-01-30 | For SittardvVVV VenloEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-01-30 | AFC WimbledonvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2021-01-30 | EvertonvNewcastlePremier League · England | 0–2 | Premier League · England |
| 2021-01-30 | NiortvLe HavreLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-01-30 | LincolnvDoncasterLeague One · England | 0–1 | League One · England |
| 2021-01-30 | PalmeirasvSantosCopa Libertadores | 1–0 | Copa Libertadores |
| 2021-01-30 | IntervBeneventoSerie A · Italy | 4–0 | Serie A · Italy |
| 2021-01-30 | NorwichvMiddlesbroughChampionship · England | 0–0 | Championship · England |
| 2021-01-30 | Bayern MunichvHoffenheimBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2021-01-30 | AlcorconvMalagaLaLiga 2 · Spain | 0–1 | LaLiga 2 · Spain |
| 2021-01-30 | Gornik Z.vLech PoznanEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-01-30 | AltachvSturm GrazAustrian Bundesliga · Austria | 2–1 | Austrian Bundesliga · Austria |
| 2021-01-30 | LarisavVolos NFCSuper League Greece · Greece | 0–0 | Super League Greece · Greece |
| 2021-01-30 | BirminghamvCoventryChampionship · England | 1–1 | Championship · England |
| 2021-01-30 | Warta PoznanvCracoviaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-01-30 | ToulousevClermontLigue 2 · France | 3–2 | Ligue 2 · France |
| 2021-01-30 | EibarvSevillaLaLiga · Spain | 0–2 | LaLiga · Spain |
| 2021-01-30 | YeovilvDover AthleticNational League · England | 3–1 | National League · England |
| 2021-01-30 | Virtus EntellavCosenzaSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-01-30 | HalifaxvMaidenheadNational League · England | 2–3 | National League · England |
| 2021-01-30 | HeraclesvGroningenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-01-30 | Sheffield WedsvPrestonChampionship · England | 1–0 | Championship · England |
| 2021-01-30 | Oud-Heverlee LeuvenvBeerschot VAPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-01-30 | OxfordvFleetwood TownLeague One · England | 1–0 | League One · England |
| 2021-01-30 | UtrechtvZwolleEredivisie · Netherlands | 3–3 | Eredivisie · Netherlands |
| 2021-01-30 | OviedovAlbaceteLaLiga 2 · Spain | 0–1 | LaLiga 2 · Spain |
| 2021-01-30 | WokingvStockportNational League · England | 1–4 | National League · England |
| 2021-01-30 | MorecambevTranmereLeague Two · England | 0–1 | League Two · England |
| 2021-01-30 | CarlislevExeterLeague Two · England | 1–0 | League Two · England |
| 2021-01-30 | BolognavMilanSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-01-30 | HeartsvDunfermlineChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-01-30 | BradfordvBarrowLeague Two · England | 2–1 | League Two · England |
| 2021-01-30 | ValenciennesvDunkerqueLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-01-30 | RegensburgvDarmstadt2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-01-30 | CambridgevCrawley TownLeague Two · England | 3–1 | League Two · England |
| 2021-01-30 | AscolivBresciaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-01-30 | AyrvAlloaChampionship · Scotland | 4–1 | Championship · Scotland |
| 2021-01-30 | Boreham WoodvEastleighNational League · England | 1–2 | National League · England |
| 2021-01-30 | ValenciavElcheLaLiga · Spain | 1–0 | LaLiga · Spain |
| 2021-01-30 | ShrewsburyvPeterboroLeague One · England | 2–0 | League One · England |
| 2021-01-30 | Mazatlan FCvPachucaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-01-30 | SouthamptonvAston VillaPremier League · England | 0–1 | Premier League · England |
| 2021-01-30 | MortonvArbroathChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-01-30 | Gaz Metan MediasvAcademica ClinceniLiga I · Romania | 1–1 | Liga I · Romania |
| 2021-01-30 | Sepsi Sf. GheorghevFC VoluntariLiga I · Romania | 2–2 | Liga I · Romania |
| 2021-01-30 | Man CityvSheffield UnitedPremier League · England | 1–0 | Premier League · England |
| 2021-01-30 | KasimpasavKayserisporSüper Lig · Türkiye | 0–1 | Süper Lig · Türkiye |
| 2021-01-30 | St. GallenvZurichSwiss Super League · Switzerland | 2–3 | Swiss Super League · Switzerland |