| 2021-01-30 | Lechia GdanskvJagielloniaEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2021-01-30 | Ein FrankfurtvHerthaBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-01-30 | OldhamvSalfordLeague Two · England | 2–1 | League Two · England |
| 2021-01-30 | Dag and RedvChesterfieldNational League · England | 2–2 | National League · England |
| 2021-01-30 | FCSBvPoli IasiSuperliga · Romania | 3–1 | Superliga · Romania |
| 2021-01-30 | FenerbahcevRizesporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-01-30 | BarnetvTorquayNational League · England | 0–2 | National League · England |
| 2021-01-30 | BrentfordvWycombeChampionship · England | 7–2 | Championship · England |
| 2021-01-30 | PisavReggianaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-01-30 | Asteras TripolisvArisSuper League · Greece | 2–1 | Super League · Greece |
| 2021-01-30 | KilmarnockvSt JohnstonePremiership · Scotland | 2–3 | Premiership · Scotland |
| 2021-01-30 | GuingampvPau FCLigue 2 · France | 2–3 | Ligue 2 · France |
| 2021-01-30 | Real MadridvLevanteLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-01-30 | MontpelliervLensLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-01-30 | NancyvParis FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-01-30 | SunderlandvGillinghamLeague One · England | 2–2 | League One · England |
| 2021-01-30 | RodezvSochauxLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-01-30 | CardiffvMillwallChampionship · England | 1–1 | Championship · England |
| 2021-01-30 | PanathinaikosvLamiaSuper League · Greece | 0–0 | Super League · Greece |
| 2021-01-30 | Union BerlinvM'gladbachBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-01-30 | DerbyvBristol CityChampionship · England | 1–0 | Championship · England |
| 2021-01-30 | Bristol RvsvRochdaleLeague One · England | 1–2 | League One · England |
| 2021-01-30 | MechelenvGenkPro League · Belgium | 0–0 | Pro League · Belgium |
| 2021-01-30 | RiedvAdmiraBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-01-30 | KortrijkvCharleroiPro League · Belgium | 1–3 | Pro League · Belgium |
| 2021-01-30 | HartlepoolvSuttonNational League · England | 1–0 | National League · England |
| 2021-01-30 | Holstein KielvBraunschweig2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |
| 2021-01-30 | AmiensvChateaurouxLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-01-30 | EupenvMouscronPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-01-30 | MallorcavGironaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-01-30 | DortmundvAugsburgBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2021-01-30 | NacionalvFamalicaoPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-01-30 | TondelavFarensePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-01-30 | SampdoriavJuventusSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-01-30 | HullvSwindonLeague One · England | 1–0 | League One · England |
| 2021-01-30 | HarrogatevNewport CountyLeague Two · England | 2–1 | League Two · England |
| 2021-01-30 | BoltonvLeyton OrientLeague Two · England | 2–0 | League Two · England |
| 2021-01-30 | Forest GreenvCheltenhamLeague Two · England | 0–0 | League Two · England |
| 2021-01-30 | BuyuksehyrvHataysporSüper Lig · Turkey | 1–5 | Süper Lig · Turkey |
| 2021-01-30 | GrimsbyvStevenageLeague Two · England | 1–2 | League Two · England |
| 2021-01-30 | AlmeriavCastellonLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-01-30 | PortimonensevBoavistaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-01-30 | AjacciovGrenobleLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-01-30 | RotherhamvSwanseaChampionship · England | 1–3 | Championship · England |
| 2021-01-30 | Crystal PalacevWolvesPremier League · England | 1–0 | Premier League · England |
| 2021-01-30 | CelticvSt MirrenPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-01-30 | Raith RvsvDundeeChampionship · Scotland | 3–1 | Championship · Scotland |
| 2021-01-29 | ReadingvBournemouthChampionship · England | 3–1 | Championship · England |
| 2021-01-29 | Tigres UANLvNecaxaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-01-29 | AntwerpvWaasland-BeverenPro League · Belgium | 3–2 | Pro League · Belgium |