| 2021-01-30 | HalifaxvMaidenheadNational League · England | 2–3 | National League · England |
| 2021-01-30 | HeraclesvGroningenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-01-30 | Sheffield WedsvPrestonChampionship · England | 1–0 | Championship · England |
| 2021-01-30 | Oud-Heverlee LeuvenvBeerschot VAPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-01-30 | OxfordvFleetwood TownLeague One · England | 1–0 | League One · England |
| 2021-01-30 | UtrechtvZwolleEredivisie · Netherlands | 3–3 | Eredivisie · Netherlands |
| 2021-01-30 | OviedovAlbaceteLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-01-30 | WokingvStockportNational League · England | 1–4 | National League · England |
| 2021-01-30 | MorecambevTranmereLeague Two · England | 0–1 | League Two · England |
| 2021-01-30 | CarlislevExeterLeague Two · England | 1–0 | League Two · England |
| 2021-01-30 | BolognavMilanSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-01-30 | HeartsvDunfermlineChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-01-30 | BradfordvBarrowLeague Two · England | 2–1 | League Two · England |
| 2021-01-30 | ValenciennesvDunkerqueLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-01-30 | RegensburgvDarmstadt2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-01-30 | CambridgevCrawley TownLeague Two · England | 3–1 | League Two · England |
| 2021-01-30 | AscolivBresciaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-01-30 | AyrvAlloaChampionship · Scotland | 4–1 | Championship · Scotland |
| 2021-01-30 | Boreham WoodvEastleighNational League · England | 1–2 | National League · England |
| 2021-01-30 | ValenciavElcheLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-01-30 | ShrewsburyvPeterboroLeague One · England | 2–0 | League One · England |
| 2021-01-30 | Mazatlan FCvPachucaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-01-30 | SouthamptonvAston VillaPremier League · England | 0–1 | Premier League · England |
| 2021-01-30 | MortonvArbroathChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-01-30 | Gaz Metan MediasvAcademica ClinceniSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-01-30 | Sepsi Sf. GheorghevFC VoluntariSuperliga · Romania | 2–2 | Superliga · Romania |
| 2021-01-30 | Man CityvSheffield UnitedPremier League · England | 1–0 | Premier League · England |
| 2021-01-30 | KasimpasavKayserisporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-01-30 | St. GallenvZurichSuper League · Switzerland | 2–3 | Super League · Switzerland |
| 2021-01-30 | Kings LynnvWrexhamNational League · England | 0–2 | National League · England |
| 2021-01-30 | ArsenalvMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2021-01-30 | PordenonevLecceSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-01-30 | Dundee UnitedvHibernianPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2021-01-30 | EmpolivFrosinoneSerie B · Italy | 3–1 | Serie B · Italy |
| 2021-01-30 | BromleyvAldershotNational League · England | 2–0 | National League · England |
| 2021-01-30 | BlackburnvLutonChampionship · England | 1–0 | Championship · England |
| 2021-01-30 | VitessevWaalwijkEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-01-30 | Port ValevSouthendLeague Two · England | 5–1 | League Two · England |
| 2021-01-30 | Nott'm ForestvBarnsleyChampionship · England | 0–0 | Championship · England |
| 2021-01-30 | West BromvFulhamPremier League · England | 2–2 | Premier League · England |
| 2021-01-30 | LivingstonvAberdeenPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-01-30 | ChamblyvCaenLigue 2 · France | 4–2 | Ligue 2 · France |
| 2021-01-30 | CrewevIpswichLeague One · England | 1–1 | League One · England |
| 2021-01-30 | PlymouthvAccringtonLeague One · England | 2–2 | League One · England |
| 2021-01-30 | VillarrealvSociedadLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-01-30 | Werder BremenvSchalke 04Bundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-01-30 | WeymouthvNotts CountyNational League · England | 0–1 | National League · England |
| 2021-01-30 | TroyesvAuxerreLigue 2 · France | 3–1 | Ligue 2 · France |
| 2021-01-30 | HuddersfieldvStokeChampionship · England | 1–1 | Championship · England |
| 2021-01-30 | HamburgvPaderborn2. Bundesliga · Germany | 3–1 | 2. Bundesliga · Germany |