| 2018-01-06 | AlloavAlbion RvsLeague One · Scotland | 3–1 | League One · Scotland |
| 2018-01-06 | EbbsfleetvChesterNational League · England | 0–1 | National League · England |
| 2018-01-06 | StirlingvBerwickLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2018-01-06 | SevillavBetisLaLiga · Spain | 3–5 | LaLiga · Spain |
| 2018-01-06 | AtlasvClub LeonLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2018-01-06 | PanetolikosvAEKSuper League Greece · Greece | 1–4 | Super League Greece · Greece |
| 2018-01-06 | SpalvLazioSerie A · Italy | 2–5 | Serie A · Italy |
| 2018-01-06 | StenhousemuirvPeterheadLeague Two · Scotland | 1–4 | League Two · Scotland |
| 2018-01-06 | Leyton OrientvBoreham WoodNational League · England | 0–0 | National League · England |
| 2018-01-06 | MaidenheadvHalifaxNational League · England | 0–0 | National League · England |
| 2018-01-06 | Sp BragavRio AvePrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2018-01-06 | Annan AthleticvMontroseLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2018-01-06 | GenoavSassuoloSerie A · Italy | 1–0 | Serie A · Italy |
| 2018-01-06 | Ath MadridvGetafeLaLiga · Spain | 2–0 | LaLiga · Spain |
| 2018-01-06 | RomavAtalantaSerie A · Italy | 1–2 | Serie A · Italy |
| 2018-01-06 | ColchestervCheltenhamLeague Two · England | 1–4 | League Two · England |
| 2018-01-06 | GrimsbyvMorecambeLeague Two · England | 0–2 | League Two · England |
| 2018-01-06 | MilanvCrotoneSerie A · Italy | 1–0 | Serie A · Italy |
| 2018-01-06 | AyrvArbroathLeague One · Scotland | 1–2 | League One · Scotland |
| 2018-01-06 | Sp GijonvCordobaLaLiga 2 · Spain | 3–2 | LaLiga 2 · Spain |
| 2018-01-06 | NorthamptonvSouthendLeague One · England | 3–1 | League One · England |
| 2018-01-06 | Dag and RedvHartlepoolNational League · England | 4–2 | National League · England |
| 2018-01-06 | OxfordvBlackpoolLeague One · England | 1–0 | League One · England |
| 2018-01-06 | Reus DeportiuvAlcorconLaLiga 2 · Spain | 1–1 | LaLiga 2 · Spain |
| 2018-01-06 | St MirrenvInverness CChampionship · Scotland | 1–0 | Championship · Scotland |
| 2018-01-06 | Las PalmasvEibarLaLiga · Spain | 1–2 | LaLiga · Spain |
| 2018-01-06 | Airdrie UtdvEast FifeLeague One · Scotland | 0–0 | League One · Scotland |
| 2018-01-06 | CagliarivJuventusSerie A · Italy | 0–1 | Serie A · Italy |
| 2018-01-06 | OsasunavValladolidLaLiga 2 · Spain | 4–2 | LaLiga 2 · Spain |
| 2018-01-06 | Queens ParkvStranraerLeague One · Scotland | 2–2 | League One · Scotland |
| 2018-01-06 | BeneventovSampdoriaSerie A · Italy | 3–2 | Serie A · Italy |
| 2018-01-06 | MacclesfieldvSolihullNational League · England | 0–0 | National League · England |
| 2018-01-06 | Cruz AzulvClub TijuanaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2018-01-06 | BromleyvFyldeNational League · England | 0–1 | National League · England |
| 2018-01-06 | LivingstonvQueen of SthChampionship · Scotland | 0–1 | Championship · Scotland |
| 2018-01-06 | CharltonvOldhamLeague One · England | 1–0 | League One · England |
| 2018-01-06 | PlymouthvBuryLeague One · England | 3–0 | League One · England |
| 2018-01-06 | Forest GreenvPort ValeLeague Two · England | 1–0 | League Two · England |
| 2018-01-06 | Raith RvsvForfarLeague One · Scotland | 2–1 | League One · Scotland |
| 2018-01-06 | DumbartonvDunfermlineChampionship · Scotland | 0–1 | Championship · Scotland |
| 2018-01-06 | WokingvMaidstoneNational League · England | 4–4 | National League · England |
| 2018-01-06 | CowdenbeathvEdinburgh CityLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2018-01-06 | BarrowvTranmereNational League · England | 1–1 | National League · England |
| 2018-01-06 | CadizvGranadaLaLiga 2 · Spain | 1–0 | LaLiga 2 · Spain |
| 2018-01-06 | FalkirkvDundee UnitedChampionship · Scotland | 6–1 | Championship · Scotland |
| 2018-01-06 | EastleighvGuiseleyNational League · England | 4–2 | National League · England |
| 2018-01-06 | WrexhamvTorquayNational League · England | 4–0 | National League · England |
| 2018-01-06 | NapolivVeronaSerie A · Italy | 2–0 | Serie A · Italy |
| 2018-01-06 | GatesheadvSuttonNational League · England | 0–2 | National League · England |
| 2018-01-06 | PueblavTigres UANLLiga MX · Mexico | 2–1 | Liga MX · Mexico |