| 2021-02-07 | ParmavBolognaSerie A · Italy | 0–3 | Serie A · Italy |
| 2021-02-07 | Erzurum BBvKayserisporSüper Lig · Türkiye | 1–1 | Süper Lig · Türkiye |
| 2021-02-07 | ServettevLuzernSwiss Super League · Switzerland | 4–2 | Swiss Super League · Switzerland |
| 2021-02-07 | GentvEupenPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-02-07 | PAOKvApollonSuper League Greece · Greece | 2–2 | Super League Greece · Greece |
| 2021-02-07 | MalagavZaragozaLaLiga 2 · Spain | 1–2 | LaLiga 2 · Spain |
| 2021-02-07 | Young BoysvLausanneSwiss Super League · Switzerland | 4–2 | Swiss Super League · Switzerland |
| 2021-02-07 | Ath BilbaovValenciaLaLiga · Spain | 1–1 | LaLiga · Spain |
| 2021-02-07 | TolucavMazatlan FCLiga MX · Mexico | 4–1 | Liga MX · Mexico |
| 2021-02-07 | BaselvSionSwiss Super League · Switzerland | 2–2 | Swiss Super League · Switzerland |
| 2021-02-07 | BetisvBarcelonaLaLiga · Spain | 2–3 | LaLiga · Spain |
| 2021-02-07 | OsasunavEibarLaLiga · Spain | 2–1 | LaLiga · Spain |
| 2021-02-07 | FCSBvAcademica ClinceniLiga I · Romania | 0–1 | Liga I · Romania |
| 2021-02-07 | Sp BragavPortoPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-02-07 | MontpelliervDijonLigue 1 · France | 4–2 | Ligue 1 · France |
| 2021-02-07 | GenkvAnderlechtPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-02-07 | Volos NFCvAsteras TripolisSuper League Greece · Greece | 0–1 | Super League Greece · Greece |
| 2021-02-07 | BeneventovSampdoriaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-02-07 | CastellonvMirandesLaLiga 2 · Spain | 0–1 | LaLiga 2 · Spain |
| 2021-02-07 | UTA AradvFC HermannstadtLiga I · Romania | 1–1 | Liga I · Romania |
| 2021-02-07 | SociedadvCadizLaLiga · Spain | 4–1 | LaLiga · Spain |
| 2021-02-07 | Greuther FurthvWurzburger Kickers2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2021-02-07 | NantesvLilleLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-02-07 | Gaz Metan MediasvChindia TargovisteLiga I · Romania | 1–0 | Liga I · Romania |
| 2021-02-07 | Sheffield UnitedvChelseaPremier League · England | 1–2 | Premier League · England |
| 2021-02-06 | GenoavNapoliSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-02-06 | MiddlesbroughvBrentfordChampionship · England | 1–4 | Championship · England |
| 2021-02-06 | Cercle BruggevMechelenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-02-06 | Man UnitedvEvertonPremier League · England | 3–3 | Premier League · England |
| 2021-02-06 | DarmstadtvNurnberg2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-02-06 | Aston VillavArsenalPremier League · England | 1–0 | Premier League · England |
| 2021-02-06 | WrexhamvDag and RedNational League · England | 2–2 | National League · England |
| 2021-02-06 | JuventusvRomaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-02-06 | MortonvRaith RvsChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-02-06 | HibernianvAberdeenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-02-06 | HeerenveenvVitesseEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-02-06 | EastleighvSolihullNational League · England | 1–1 | National League · England |
| 2021-02-06 | SwindonvShrewsburyLeague One · England | 0–1 | League One · England |
| 2021-02-06 | TroyesvToulouseLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-02-06 | LorientvReimsLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-02-06 | M'gladbachvFC KolnBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-02-06 | FreiburgvDortmundBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-02-06 | BurtonvHullLeague One · England | 1–0 | League One · England |
| 2021-02-06 | PordenonevVicenzaSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-02-06 | MonzavEmpoliSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-06 | FenerbahcevGalatasaraySüper Lig · Türkiye | 0–1 | Süper Lig · Türkiye |
| 2021-02-06 | Leyton OrientvColchesterLeague Two · England | 0–0 | League Two · England |
| 2021-02-06 | LegiavRakowEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-02-06 | ArbroathvDunfermlineChampionship · Scotland | 2–0 | Championship · Scotland |
| 2021-02-06 | BahiavGoiasBrasileirão · Brazil | 3–3 | Brasileirão · Brazil |