| 2021-11-27 | Pogon SzczecinvLechia GdanskEkstraklasa · Poland | 5–1 | Ekstraklasa · Poland |
| 2021-11-27 | Bayern MunichvBielefeldBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-11-27 | KarlsruhevHannover2. Bundesliga · Germany | 4–0 | 2. Bundesliga · Germany |
| 2021-11-27 | HuddersfieldvMiddlesbroughChampionship · England | 1–2 | Championship · England |
| 2021-11-27 | Ross CountyvDundee UnitedPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-11-27 | GrasshoppersvLuganoSwiss Super League · Switzerland | 0–1 | Swiss Super League · Switzerland |
| 2021-11-27 | Sp GijonvFuenlabradaLaLiga 2 · Spain | 1–1 | LaLiga 2 · Spain |
| 2021-11-27 | BesiktasvGiresunsporSüper Lig · Türkiye | 0–4 | Süper Lig · Türkiye |
| 2021-11-27 | CambridgevSunderlandLeague One · England | 1–2 | League One · England |
| 2021-11-27 | PrestonvFulhamChampionship · England | 1–1 | Championship · England |
| 2021-11-27 | LiverpoolvSouthamptonPremier League · England | 4–0 | Premier League · England |
| 2021-11-27 | GianninavAEKSuper League Greece · Greece | 1–2 | Super League Greece · Greece |
| 2021-11-27 | PerugiavCittadellaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-11-27 | Asteras TripolisvAtromitosSuper League Greece · Greece | 6–2 | Super League Greece · Greece |
| 2021-11-27 | Notts CountyvDag and RedNational League · England | 2–1 | National League · England |
| 2021-11-27 | SeraingvSt TruidenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-11-27 | FrosinonevPordenoneSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-11-27 | PlymouthvWiganLeague One · England | 1–2 | League One · England |
| 2021-11-27 | BurtonvDoncasterLeague One · England | 2–0 | League One · England |
| 2021-11-27 | Urawa RedsvShimizu S-PulseJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-11-27 | ScunthorpevBradfordLeague Two · England | 1–1 | League Two · England |
| 2021-11-27 | LecznavGornik Z.Ekstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-11-27 | WealdstonevStockportNational League · England | 1–4 | National League · England |
| 2021-11-27 | OxfordvRotherhamLeague One · England | 0–0 | League One · England |
| 2021-11-27 | PeterborovBarnsleyChampionship · England | 0–0 | Championship · England |
| 2021-11-27 | PatronatovGodoy CruzLiga Profesional · Argentina | 0–3 | Liga Profesional · Argentina |
| 2021-11-27 | UralvSochiRussian Premier League · Russia | 1–1 | Russian Premier League · Russia |
| 2021-11-27 | AntalyasporvAlanyasporSüper Lig · Türkiye | 3–0 | Süper Lig · Türkiye |
| 2021-11-27 | BresciavPisaSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-11-27 | Cercle BruggevMechelenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-11-27 | WokingvBarnetNational League · England | 1–2 | National League · England |
| 2021-11-27 | BrightonvLeedsPremier League · England | 0–0 | Premier League · England |
| 2021-11-27 | AscolivMonzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-11-27 | BirminghamvBlackpoolChampionship · England | 1–0 | Championship · England |
| 2021-11-27 | HullvMillwallChampionship · England | 2–1 | Championship · England |
| 2021-11-27 | VeneziavInterSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-11-27 | SalfordvOldhamLeague Two · England | 2–0 | League Two · England |
| 2021-11-27 | AlessandriavCremoneseSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-11-27 | StokevBlackburnChampionship · England | 0–1 | Championship · England |
| 2021-11-27 | AdmiravWolfsberger ACAustrian Bundesliga · Austria | 0–1 | Austrian Bundesliga · Austria |
| 2021-11-27 | Hokkaido Consadole SapporovKashiwa ReysolJ1 League · Japan | 3–1 | J1 League · Japan |
| 2021-11-27 | Crystal PalacevAston VillaPremier League · England | 1–2 | Premier League · England |
| 2021-11-27 | For SittardvGroningenEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2021-11-27 | YeovilvDover AthleticNational League · England | 1–1 | National League · England |
| 2021-11-27 | UTA AradvFC ArgesLiga I · Romania | 0–1 | Liga I · Romania |
| 2021-11-27 | RochdalevExeterLeague Two · England | 1–1 | League Two · England |
| 2021-11-27 | Akhmat GroznyvFK RostovRussian Premier League · Russia | 2–0 | Russian Premier League · Russia |
| 2021-11-27 | Forest GreenvBristol RvsLeague Two · England | 2–0 | League Two · England |
| 2021-11-27 | AlmeriavHuescaLaLiga 2 · Spain | 0–0 | LaLiga 2 · Spain |
| 2021-11-27 | EmpolivFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |