| 2008-11-16 | GalatasarayvBuyuksehyrSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2008-11-16 | EspanolvNumanciaLa Liga · Spain | 3–4 | La Liga · Spain |
| 2008-11-16 | OlympiakosvPAOKSuper League · Greece | 2–0 | Super League · Greece |
| 2008-11-16 | AlmeriavMallorcaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2008-11-16 | AjaxvPSV EindhovenEredivisie · Netherlands | 4–1 | Eredivisie · Netherlands |
| 2008-11-16 | BursasporvBesiktasSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2008-11-16 | BlackpoolvPrestonChampionship · England | 1–3 | Championship · England |
| 2008-11-16 | NicevNantesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2008-11-16 | TwentevFeyenoordEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2008-11-16 | HuescavLevanteLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2008-11-16 | KoblenzvMainz2. Bundesliga · Germany | 0–3 | 2. Bundesliga · Germany |
| 2008-11-16 | BetisvSantanderLa Liga · Spain | 3–1 | La Liga · Spain |
| 2008-11-16 | Club BruggevAnderlechtPro League · Belgium | 1–1 | Pro League · Belgium |
| 2008-11-16 | PanthrakikosvXanthiSuper League · Greece | 0–0 | Super League · Greece |
| 2008-11-16 | CeltavVallecanoLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2008-11-16 | XerezvAlavesLa Liga 2 · Spain | 5–0 | La Liga 2 · Spain |
| 2008-11-15 | HerefordvCheltenhamLeague One · England | 3–0 | League One · England |
| 2008-11-15 | NancyvCaenLigue 1 · France | 1–1 | Ligue 1 · France |
| 2008-11-15 | WaregemvGerminalPro League · Belgium | 2–2 | Pro League · Belgium |
| 2008-11-15 | BarivAnconaSerie B · Italy | 2–1 | Serie B · Italy |
| 2008-11-15 | CowdenbeathvStenhousemuirLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2008-11-15 | AEKvPanserraikosSuper League · Greece | 0–0 | Super League · Greece |
| 2008-11-15 | Roda JCvNijmegenEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2008-11-15 | DerbyvSheffield WedsChampionship · England | 3–0 | Championship · England |
| 2008-11-15 | AldershotvExeterLeague Two · England | 1–0 | League Two · England |
| 2008-11-15 | ElginvMontroseLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2008-11-15 | PortovGuimaraesPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2008-11-15 | AlbacetevSalamancaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2008-11-15 | ColchestervWalsallLeague One · England | 0–2 | League One · England |
| 2008-11-15 | CottbusvKarlsruheBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2008-11-15 | DortmundvEin FrankfurtBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2008-11-15 | Queens ParkvAyrLeague One · Scotland | 0–3 | League One · Scotland |
| 2008-11-15 | CoventryvPlymouthChampionship · England | 0–1 | Championship · England |
| 2008-11-15 | DendervKortrijkPro League · Belgium | 1–0 | Pro League · Belgium |
| 2008-11-15 | NorwichvSwanseaChampionship · England | 2–3 | Championship · England |
| 2008-11-15 | YeovilvPeterboroLeague One · England | 0–1 | League One · England |
| 2008-11-15 | ArsenalvAston VillaPremier League · England | 0–2 | Premier League · England |
| 2008-11-15 | LeverkusenvSchalke 04Bundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2008-11-15 | SwindonvLeicesterLeague One · England | 2–2 | League One · England |
| 2008-11-15 | Crawley TownvCambridgeNational League · England | 2–2 | National League · England |
| 2008-11-15 | Rushden & DvKidderminsterNational League · England | 0–1 | National League · England |
| 2008-11-15 | LillevSt EtienneLigue 1 · France | 3–0 | Ligue 1 · France |
| 2008-11-15 | YorkvTorquayNational League · England | 1–2 | National League · England |
| 2008-11-15 | Den HaagvWillem IIEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2008-11-15 | MouscronvCharleroiPro League · Belgium | 2–1 | Pro League · Belgium |
| 2008-11-15 | FenerbahcevAnkarasporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2008-11-15 | M'gladbachvBayern MunichBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2008-11-15 | RangersvSt MirrenPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2008-11-15 | Bristol CityvNott'm ForestChampionship · England | 2–2 | Championship · England |
| 2008-11-15 | PiacenzavSassuoloSerie B · Italy | 2–2 | Serie B · Italy |