| 2021-02-06 | AlloavQueen of SthChampionship · Scotland | 2–1 | Championship · Scotland |
| 2021-02-06 | CoventryvWatfordChampionship · England | 0–0 | Championship · England |
| 2021-02-06 | SevillavGetafeLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-02-06 | FC EmmenvAZ AlkmaarEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-02-06 | BarrowvCambridgeLeague Two · England | 0–2 | League Two · England |
| 2021-02-06 | OsnabruckvBochum2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-02-06 | FuenlabradavAlmeriaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-02-06 | OostendevSt TruidenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-02-06 | WiganvAFC WimbledonLeague One · England | 2–3 | League One · England |
| 2021-02-06 | CelticvMotherwellPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-02-06 | CartagenavOviedoLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-02-06 | LutonvHuddersfieldChampionship · England | 1–1 | Championship · England |
| 2021-02-06 | LogronesvSp GijonLa Liga 2 · Spain | 0–4 | La Liga 2 · Spain |
| 2021-02-06 | Pogon SzczecinvCracoviaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-02-06 | RochdalevCharltonLeague One · England | 0–2 | League One · England |
| 2021-02-06 | NewcastlevSouthamptonPremier League · England | 3–2 | Premier League · England |
| 2021-02-06 | KasimpasavHataysporSüper Lig · Turkey | 1–4 | Süper Lig · Turkey |
| 2021-02-06 | BournemouthvBirminghamChampionship · England | 3–2 | Championship · England |
| 2021-02-06 | HuescavReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-02-06 | AlanyasporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-02-06 | BurnleyvBrightonPremier League · England | 1–1 | Premier League · England |
| 2021-02-06 | St MirrenvKilmarnockPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-02-06 | Milton Keynes DonsvSunderlandLeague One · England | 2–2 | League One · England |
| 2021-02-06 | BresciavCittadellaSerie B · Italy | 3–3 | Serie B · Italy |
| 2021-02-06 | ElchevVillarrealLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-02-06 | SassuolovSpeziaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-02-06 | NecaxavCruz AzulLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-02-06 | AstravFC ArgesSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-02-06 | PeterborovCreweLeague One · England | 2–0 | League One · England |
| 2021-02-06 | U CraiovavDin. BucurestiSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-02-06 | AtlasvSantos LagunaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-02-06 | DoncastervOxfordLeague One · England | 3–2 | League One · England |
| 2021-02-06 | LensvRennesLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-02-06 | CremonesevPisaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-02-06 | Piast GliwicevSlask WroclawEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-02-06 | PrestonvRotherhamChampionship · England | 1–2 | Championship · England |
| 2021-02-06 | MaidenheadvBoreham WoodNational League · England | 0–1 | National League · England |
| 2021-02-06 | FulhamvWest HamPremier League · England | 0–0 | Premier League · England |
| 2021-02-06 | PescaravRegginaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-02-06 | QPRvBlackburnChampionship · England | 1–0 | Championship · England |
| 2021-02-06 | IpswichvBlackpoolLeague One · England | 2–0 | League One · England |
| 2021-02-06 | Fleetwood TownvBristol RvsLeague One · England | 0–0 | League One · England |
| 2021-02-06 | MainzvUnion BerlinBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2021-02-06 | AccringtonvNorthamptonLeague One · England | 0–0 | League One · England |
| 2021-02-06 | SalernitanavChievoSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-06 | AugsburgvWolfsburgBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2021-02-06 | PSV EindhovenvTwenteEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-02-06 | WeymouthvBromleyNational League · England | 2–1 | National League · England |
| 2021-02-06 | Newport CountyvGrimsbyLeague Two · England | 1–0 | League Two · England |
| 2021-02-06 | Crawley TownvHarrogateLeague Two · England | 1–3 | League Two · England |