| 2021-02-07 | SociedadvCadizLa Liga · Spain | 4–1 | La Liga · Spain |
| 2021-02-07 | Greuther FurthvWurzburger Kickers2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2021-02-07 | NantesvLilleLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-02-07 | Gaz Metan MediasvChindia TargovisteSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-02-07 | Sheffield UnitedvChelseaPremier League · England | 1–2 | Premier League · England |
| 2021-02-06 | GenoavNapoliSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-02-06 | MiddlesbroughvBrentfordChampionship · England | 1–4 | Championship · England |
| 2021-02-06 | Cercle BruggevMechelenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2021-02-06 | Man UnitedvEvertonPremier League · England | 3–3 | Premier League · England |
| 2021-02-06 | DarmstadtvNurnberg2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-02-06 | Aston VillavArsenalPremier League · England | 1–0 | Premier League · England |
| 2021-02-06 | WrexhamvDag and RedNational League · England | 2–2 | National League · England |
| 2021-02-06 | JuventusvRomaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-02-06 | MortonvRaith RvsChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-02-06 | HibernianvAberdeenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-02-06 | HeerenveenvVitesseEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-02-06 | EastleighvSolihullNational League · England | 1–1 | National League · England |
| 2021-02-06 | SwindonvShrewsburyLeague One · England | 0–1 | League One · England |
| 2021-02-06 | TroyesvToulouseLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-02-06 | LorientvReimsLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-02-06 | M'gladbachvFC KolnBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-02-06 | FreiburgvDortmundBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-02-06 | BurtonvHullLeague One · England | 1–0 | League One · England |
| 2021-02-06 | PordenonevVicenzaSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-02-06 | MonzavEmpoliSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-06 | FenerbahcevGalatasaraySüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-02-06 | Leyton OrientvColchesterLeague Two · England | 0–0 | League Two · England |
| 2021-02-06 | LegiavRakowEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-02-06 | ArbroathvDunfermlineChampionship · Scotland | 2–0 | Championship · Scotland |
| 2021-02-06 | BahiavGoiasSerie A · Brazil | 3–3 | Serie A · Brazil |
| 2021-02-06 | CosenzavSpalSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-06 | MillwallvSheffield WedsChampionship · England | 4–1 | Championship · England |
| 2021-02-06 | Waasland-BeverenvClub BruggePro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-02-06 | FrosinonevVeneziaSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-02-06 | StokevReadingChampionship · England | 0–0 | Championship · England |
| 2021-02-06 | Le HavrevParis FCLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-02-06 | LeverkusenvStuttgartBundesliga · Germany | 5–2 | Bundesliga · Germany |
| 2021-02-06 | BuyuksehyrvKaragumrukSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-02-06 | AtalantavTorinoSerie A · Italy | 3–3 | Serie A · Italy |
| 2021-02-06 | LivingstonvSt JohnstonePremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-02-06 | StandardvOud-Heverlee LeuvenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-02-06 | PortsmouthvPlymouthLeague One · England | 2–2 | League One · England |
| 2021-02-06 | StevenagevMorecambeLeague Two · England | 2–2 | League Two · England |
| 2021-02-06 | StockportvYeovilNational League · England | 1–0 | National League · England |
| 2021-02-06 | LevantevGranadaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2021-02-06 | TranmerevPort ValeLeague Two · England | 3–1 | League Two · England |
| 2021-02-06 | Schalke 04vRB LeipzigBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2021-02-06 | Bristol CityvCardiffChampionship · England | 0–2 | Championship · England |
| 2021-02-06 | ZwollevWaalwijkEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-02-06 | BraunschweigvHannover2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |