| 2021-02-07 | DenizlisporvAntalyasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-02-07 | MonterreyvUNAM PumasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-02-07 | LiverpoolvMan CityPremier League · England | 1–4 | Premier League · England |
| 2021-02-07 | CharleroivWaregemPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-02-07 | St EtiennevMetzLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-02-07 | OlympiakosvOFI CreteSuper League · Greece | 3–0 | Super League · Greece |
| 2021-02-07 | SonderjyskevVejleSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-02-07 | Beerschot VAvAntwerpPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-02-07 | Las PalmasvSabadellLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-02-07 | AnkaragucuvSivassporSüper Lig · Turkey | 1–4 | Süper Lig · Turkey |
| 2021-02-07 | VallecanovTenerifeLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-02-07 | WolvesvLeicesterPremier League · England | 0–0 | Premier League · England |
| 2021-02-07 | BesiktasvKonyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-02-07 | PodbeskidzievGornik Z.Ekstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-02-07 | BragantinovFlamengo RJSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-02-07 | ReggianavVirtus EntellaSerie B · Italy | 2–1 | Serie B · Italy |
| 2021-02-07 | BrondbyvAalborgSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-02-07 | LaziovCagliariSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-02-07 | BrestvBordeauxLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-02-07 | MarseillevParis SGLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-02-07 | WislavJagielloniaEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-02-07 | GironavLeganesLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2021-02-07 | Nimesv MonacoLigue 1 · France | 3–4 | Ligue 1 · France |
| 2021-02-07 | KarlsruhevRegensburg2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-02-07 | NicevAngersLigue 1 · France | 3–0 | Ligue 1 · France |
| 2021-02-07 | TottenhamvWest BromPremier League · England | 2–0 | Premier League · England |
| 2021-02-07 | AEKvArisSuper League · Greece | 0–2 | Super League · Greece |
| 2021-02-07 | UdinesevVeronaSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-02-07 | MilanvCrotoneSerie A · Italy | 4–0 | Serie A · Italy |
| 2021-02-07 | NordsjaellandvOdenseSuperliga · Denmark | 0–2 | Superliga · Denmark |
| 2021-02-07 | ParmavBolognaSerie A · Italy | 0–3 | Serie A · Italy |
| 2021-02-07 | Erzurum BBvKayserisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-02-07 | ServettevLuzernSuper League · Switzerland | 4–2 | Super League · Switzerland |
| 2021-02-07 | GentvEupenPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-02-07 | PAOKvApollonSuper League · Greece | 2–2 | Super League · Greece |
| 2021-02-07 | MalagavZaragozaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-02-07 | Young BoysvLausanneSuper League · Switzerland | 4–2 | Super League · Switzerland |
| 2021-02-07 | Ath BilbaovValenciaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-02-07 | TolucavMazatlan FCLiga MX · Mexico | 4–1 | Liga MX · Mexico |
| 2021-02-07 | BaselvSionSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-02-07 | BetisvBarcelonaLa Liga · Spain | 2–3 | La Liga · Spain |
| 2021-02-07 | OsasunavEibarLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-02-07 | FCSBvAcademica ClinceniSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-02-07 | Sp BragavPortoPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-02-07 | MontpelliervDijonLigue 1 · France | 4–2 | Ligue 1 · France |
| 2021-02-07 | GenkvAnderlechtPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-02-07 | Volos NFCvAsteras TripolisSuper League · Greece | 0–1 | Super League · Greece |
| 2021-02-07 | BeneventovSampdoriaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-02-07 | CastellonvMirandesLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-02-07 | UTA AradvFC HermannstadtSuperliga · Romania | 1–1 | Superliga · Romania |