| 2022-01-22 | SalfordvColchesterLeague Two · England | 0–3 | League Two · England |
| 2022-01-22 | ScunthorpevNewport CountyLeague Two · England | 0–1 | League Two · England |
| 2022-01-22 | StokevFulhamChampionship · England | 2–3 | Championship · England |
| 2022-01-22 | BournemouthvHullChampionship · England | 0–1 | Championship · England |
| 2022-01-22 | Greuther FurthvMainzBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-01-22 | Bristol CityvCardiffChampionship · England | 3–2 | Championship · England |
| 2022-01-22 | Chindia TargovistevFC VoluntariSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-01-22 | ClydevQueens ParkLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-01-22 | MoreirensevSanta ClaraPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2022-01-22 | Nott'm ForestvDerbyChampionship · England | 2–1 | Championship · England |
| 2022-01-22 | HeerenveenvZwolleEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-01-22 | GrimsbyvBromleyNational League · England | 1–2 | National League · England |
| 2022-01-22 | HarrogatevOldhamLeague Two · England | 3–0 | League Two · England |
| 2022-01-22 | M'gladbachvUnion BerlinBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-01-22 | BochumvFC KolnBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2022-01-22 | ComovCrotoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-01-22 | BastiavToulouseLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-01-22 | BirminghamvBarnsleyChampionship · England | 2–1 | Championship · England |
| 2022-01-22 | BarrowvMansfieldLeague Two · England | 1–3 | League Two · England |
| 2022-01-22 | AmiensvGuingampLigue 2 · France | 3–0 | Ligue 2 · France |
| 2022-01-22 | Crawley TownvTranmereLeague Two · England | 0–1 | League Two · England |
| 2022-01-22 | Hansa RostockvHeidenheim2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-01-22 | ChesterfieldvAldershotNational League · England | 0–0 | National League · England |
| 2022-01-22 | LensvMarseilleLigue 1 · France | 0–2 | Ligue 1 · France |
| 2022-01-22 | SuttonvNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2022-01-22 | Milton Keynes DonsvDoncasterLeague One · England | 0–1 | League One · England |
| 2022-01-22 | RotherhamvCheltenhamLeague One · England | 1–0 | League One · England |
| 2022-01-22 | AZ AlkmaarvCambuurEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2022-01-22 | St TruidenvSeraingPro League · Belgium | 3–1 | Pro League · Belgium |
| 2022-01-22 | MorecambevWycombeLeague One · England | 3–2 | League One · England |
| 2022-01-22 | LeverkusenvAugsburgBundesliga · Germany | 5–1 | Bundesliga · Germany |
| 2022-01-22 | PlymouthvLincolnLeague One · England | 1–2 | League One · England |
| 2022-01-22 | ZaragozavValladolidLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-01-22 | CoventryvQPRChampionship · England | 1–2 | Championship · England |
| 2022-01-22 | BlackpoolvMillwallChampionship · England | 1–0 | Championship · England |
| 2022-01-22 | HartlepoolvStevenageLeague Two · England | 1–1 | League Two · England |
| 2022-01-22 | PaderbornvWerder Bremen2. Bundesliga · Germany | 3–4 | 2. Bundesliga · Germany |
| 2022-01-22 | Willem IIvTwenteEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-01-22 | LevantevCadizLa Liga · Spain | 0–2 | La Liga · Spain |
| 2022-01-22 | IntervVeneziaSerie A · Italy | 2–1 | Serie A · Italy |
| 2022-01-22 | DijonvQuevilly RouenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-01-22 | Ath MadridvValenciaLa Liga · Spain | 3–2 | La Liga · Spain |
| 2022-01-22 | BresciavTernanaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-01-22 | IngolstadtvDarmstadt2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-01-21 | EspanolvBetisLa Liga · Spain | 1–4 | La Liga · Spain |
| 2022-01-21 |  Iraqv UgandaFriendly | 1–0 | Friendly |
| 2022-01-21 | Ein FrankfurtvBielefeldBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-01-21 | FC ArgesvDin. BucurestiSuperliga · Romania | 2–1 | Superliga · Romania |
| 2022-01-21 | SouthendvKings LynnNational League · England | 2–1 | National League · England |
| 2022-01-21 | AroucavBenficaPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |