| 2021-02-13 | Din. BucurestivSepsi Sf. GheorgheSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-02-13 | NapolivJuventusSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-02-13 | PortovBoavistaPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-02-13 | Werder BremenvFreiburgBundesliga · Germany | 0–0 | Bundesliga · Germany |
| 2021-02-13 | BoltonvStevenageLeague Two · England | 1–0 | League Two · England |
| 2021-02-13 | GroningenvZwolleEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-02-13 | St TruidenvWaregemPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-02-12 | BlackburnvPrestonChampionship · England | 1–2 | Championship · England |
| 2021-02-12 | RB LeipzigvAugsburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-02-12 | BanfieldvRacing ClubCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2021-02-12 | CeltavElcheLa Liga · Spain | 3–1 | La Liga · Spain |
| 2021-02-12 | HannovervPaderborn2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-02-12 | MonzavPisaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-02-12 | BolognavBeneventoSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-02-12 | Slask WroclawvWislaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-02-12 | Oud-Heverlee LeuvenvKortrijkPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-02-12 | FamalicaovBelenensesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-02-12 | RizesporvErzurum BBSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2021-02-12 | WaalwijkvFC EmmenEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-02-12 | Holstein KielvWurzburger Kickers2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-02-12 | Queen of SthvHeartsChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-02-12 | SabadellvZaragozaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-02-12 | FC ArgesvViitorul ConstantaSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-02-11 | CorinthiansvAthletico-PRSerie A · Brazil | 3–3 | Serie A · Brazil |
| 2021-02-11 | Sao PaulovCearaSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-02-11 | FluminensevAtletico-MGSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-02-10 | ServettevSt. GallenSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-02-10 | FortalezavVascoSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-02-10 | Young BoysvLausanneSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2021-02-10 | LuzernvLuganoSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-02-10 | RegginavVirtus EntellaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-02-10 | AdmiravAltachBundesliga · Austria | 3–1 | Bundesliga · Austria |
| 2021-02-10 | KilmarnockvMotherwellPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2021-02-10 | St. PoltenvLASKBundesliga · Austria | 1–3 | Bundesliga · Austria |
| 2021-02-10 | ReadingvBrentfordChampionship · England | 1–3 | Championship · England |
| 2021-02-10 | SalzburgvAustria ViennaBundesliga · Austria | 3–1 | Bundesliga · Austria |
| 2021-02-10 | ChievovReggianaSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-02-10 | InternacionalvSport RecifeSerie A · Brazil | 1–2 | Serie A · Brazil |
| 2021-02-10 | St MirrenvCelticPremiership · Scotland | 0–4 | Premiership · Scotland |
| 2021-02-09 | WalsallvMansfieldLeague Two · England | 1–1 | League Two · England |
| 2021-02-09 | SpalvPordenoneSerie B · Italy | 1–3 | Serie B · Italy |
| 2021-02-09 | Gil VicentevSp LisbonPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-02-09 | TorquayvWealdstoneNational League · England | 1–1 | National League · England |
| 2021-02-09 | ShrewsburyvSunderlandLeague One · England | 2–1 | League One · England |
| 2021-02-09 | Pacos FerreiravPortimonensePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-02-09 | PeterborovIpswichLeague One · England | 2–1 | League One · England |
| 2021-02-09 | AltrinchamvWrexhamNational League · England | 1–2 | National League · England |
| 2021-02-09 | Sheffield WedsvWycombeChampionship · England | 2–0 | Championship · England |
| 2021-02-09 | EmpolivPescaraSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-02-09 | Fleetwood TownvDoncasterLeague One · England | 3–1 | League One · England |