| 2022-01-23 | MechelenvAnderlechtPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-01-23 | Volos NFCvPAOKSuper League · Greece | 0–4 | Super League · Greece |
| 2022-01-23 | NapolivSalernitanaSerie A · Italy | 4–1 | Serie A · Italy |
| 2022-01-23 | OlympiakosvGianninaSuper League · Greece | 2–0 | Super League · Greece |
| 2022-01-23 | GuimaraesvEstorilPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2022-01-23 | Real MadridvElcheLa Liga · Spain | 2–2 | La Liga · Spain |
| 2022-01-23 | HataysporvRizesporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-01-23 | ArisvLamiaSuper League · Greece | 0–0 | Super League · Greece |
| 2022-01-23 | HeraclesvGo Ahead EaglesEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-01-23 | VallecanovAth BilbaoLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-01-23 | Club AmericavAtlasLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2022-01-23 | BurgosvLeganesLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2022-01-23 | Sp GijonvAmorebietaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-01-23 |  Nigeriav TunisiaAfrican Cup of Nations | 0–1 | African Cup of Nations |
| 2022-01-23 | WaalwijkvFor SittardEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-01-23 | PSV EindhovenvAjaxEredivisie · Netherlands | 1–2 | Eredivisie · Netherlands |
| 2022-01-23 | GranadavOsasunaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2022-01-23 | RB LeipzigvWolfsburgBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-01-23 | ChelseavTottenhamPremier League · England | 2–0 | Premier League · England |
| 2022-01-23 | HerthavBayern MunichBundesliga · Germany | 1–4 | Bundesliga · Germany |
| 2022-01-23 | Montpellierv MonacoLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-01-23 | SpeziavSampdoriaSerie A · Italy | 1–0 | Serie A · Italy |
| 2022-01-23 | Gil VicentevPortimonensePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-01-23 | Club LeonvPachucaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-01-23 | TorinovSassuoloSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-01-23 | AtromitosvAEKSuper League · Greece | 0–2 | Super League · Greece |
| 2022-01-23 | EmpolivRomaSerie A · Italy | 2–4 | Serie A · Italy |
| 2022-01-23 | BordeauxvStrasbourgLigue 1 · France | 4–3 | Ligue 1 · France |
| 2022-01-23 | StandardvClub BruggePro League · Belgium | 2–2 | Pro League · Belgium |
| 2022-01-23 | GironavLugoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-01-23 | ArsenalvBurnleyPremier League · England | 0–0 | Premier League · England |
| 2022-01-23 | GalatasarayvTrabzonsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-01-23 | NantesvLorientLigue 1 · France | 4–2 | Ligue 1 · France |
| 2022-01-23 | ClermontvRennesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-01-23 | UNAM PumasvTigres UANLLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2022-01-23 | St. GilloisevGenkPro League · Belgium | 2–1 | Pro League · Belgium |
| 2022-01-22 | AlessandriavBeneventoSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-01-22 | Man UnitedvWest HamPremier League · England | 1–0 | Premier League · England |
| 2022-01-22 | LeedsvNewcastlePremier League · England | 0–1 | Premier League · England |
| 2022-01-22 | Boreham WoodvWeymouthNational League · England | 1–1 | National League · England |
| 2022-01-22 | CharltonvFleetwood TownLeague One · England | 2–0 | League One · England |
| 2022-01-22 | WokingvWealdstoneNational League · England | 2–0 | National League · England |
| 2022-01-22 | IpswichvAccringtonLeague One · England | 2–1 | League One · England |
| 2022-01-22 | WalsallvExeterLeague Two · England | 0–2 | League Two · England |
| 2022-01-22 | SunderlandvPortsmouthLeague One · England | 1–0 | League One · England |
| 2022-01-22 | Sheffield UnitedvLutonChampionship · England | 2–0 | Championship · England |
| 2022-01-22 | LaziovAtalantaSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-01-22 | PerugiavPordenoneSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-01-22 | FreiburgvStuttgartBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-01-22 | SevillavCeltaLa Liga · Spain | 2–2 | La Liga · Spain |