| 2021-02-13 | ClermontvChamblyLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-02-13 | Velez SarsfieldvNewells Old BoysCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-02-13 | GrenoblevAmiensLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-02-13 | Chindia TargovistevUTA AradSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-02-13 | LeverkusenvMainzBundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2021-02-13 | HamburgvGreuther Furth2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-02-13 | SandhausenvKarlsruhe2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-02-13 | PordenonevCittadellaSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-02-13 | Union de Santa FevAtl. TucumanCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2021-02-13 | DunkerquevNancyLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-02-13 | CracoviavPodbeskidzieEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-02-13 | Crystal PalacevBurnleyPremier League · England | 0–3 | Premier League · England |
| 2021-02-13 | CharltonvGillinghamLeague One · England | 2–3 | League One · England |
| 2021-02-13 | WatfordvBristol CityChampionship · England | 6–0 | Championship · England |
| 2021-02-13 | SalernitanavVicenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-13 | CaenvNiortLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-02-13 | ReadingvMillwallChampionship · England | 1–2 | Championship · England |
| 2021-02-13 | Nott'm ForestvBournemouthChampionship · England | 0–0 | Championship · England |
| 2021-02-13 | SevillavHuescaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-02-13 | ChateaurouxvLe HavreLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-02-13 | StuttgartvHerthaBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-02-13 | SuttonvBoreham WoodNational League · England | 2–0 | National League · England |
| 2021-02-13 | ReimsvLensLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-02-13 | SunderlandvDoncasterLeague One · England | 4–1 | League One · England |
| 2021-02-13 | StockportvAldershotNational League · England | 0–0 | National League · England |
| 2021-02-13 | GoiasvBotafogo RJSerie A · Brazil | 2–0 | Serie A · Brazil |
| 2021-02-13 | Man CityvTottenhamPremier League · England | 3–0 | Premier League · England |
| 2021-02-13 | AlloavArbroathChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-02-13 | Paris SGvNiceLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-02-13 | PueblavJuarezLiga MX · Mexico | 4–0 | Liga MX · Mexico |
| 2021-02-13 | TirolvSalzburgBundesliga · Austria | 2–4 | Bundesliga · Austria |
| 2021-02-13 | BarcelonavAlavesLa Liga · Spain | 5–1 | La Liga · Spain |
| 2021-02-13 | Wolfsberger ACvAdmiraBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-02-13 | RangersvKilmarnockPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-02-13 | Club TijuanavClub LeonLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-02-13 | RakowvLechia GdanskEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-02-13 | AberdeenvSt MirrenPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2021-02-13 | HullvMilton Keynes DonsLeague One · England | 0–1 | League One · England |
| 2021-02-13 | NacionalvFarensePrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2021-02-13 | AltachvSK RapidBundesliga · Austria | 0–0 | Bundesliga · Austria |
| 2021-02-13 | KayserisporvAnkaragucuSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-02-13 | Atletico-MGvBahiaSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-02-13 | Asteras TripolisvLamiaSuper League · Greece | 0–0 | Super League · Greece |
| 2021-02-13 | LyonvMontpellierLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-02-13 | HeidenheimvErzgebirge Aue2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-02-13 | MotherwellvHamiltonPremiership · Scotland | 1–4 | Premiership · Scotland |
| 2021-02-13 | Den HaagvPSV EindhovenEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-02-13 | SpalvEmpoliSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-13 | SpeziavMilanSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-02-13 | Mazatlan FCvAtl. San LuisLiga MX · Mexico | 0–3 | Liga MX · Mexico |