| 2016-01-17 | MallorcavValladolidLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2016-01-17 | RomavVeronaSerie A · Italy | 1–1 | Serie A · Italy |
| 2016-01-17 | LugovHuescaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-01-17 | Dorados de SinaloavClub TijuanaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2016-01-17 | FeyenoordvPSV EindhovenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2016-01-17 | PAOKvVeriaSuper League · Greece | 2–1 | Super League · Greece |
| 2016-01-17 | PanathinaikosvPanioniosSuper League · Greece | 0–0 | Super League · Greece |
| 2016-01-17 | StokevArsenalPremier League · England | 0–0 | Premier League · England |
| 2016-01-17 | LiverpoolvMan UnitedPremier League · England | 0–1 | Premier League · England |
| 2016-01-17 | Tigres UANLvMonarcasLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2016-01-17 | MillwallvPort ValeLeague One · England | 3–1 | League One · England |
| 2016-01-17 | AntalyasporvBuyuksehyrSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2016-01-17 | GroningenvUtrechtEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2016-01-17 | GetafevEspanolLa Liga · Spain | 3–1 | La Liga · Spain |
| 2016-01-17 | BarcelonavAth BilbaoLa Liga · Spain | 6–0 | La Liga · Spain |
| 2016-01-17 | PachucavQueretaroLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2016-01-17 | NijmegenvWillem IIEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2016-01-17 | Lorientv MonacoLigue 1 · France | 0–2 | Ligue 1 · France |
| 2016-01-17 | OostendevWaasland-BeverenPro League · Belgium | 3–3 | Pro League · Belgium |
| 2016-01-17 | AroucavMoreirensePrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2016-01-17 | Rio AvevBelenensesPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2016-01-17 | FalkirkvHibernianChampionship · Scotland | 1–1 | Championship · Scotland |
| 2016-01-17 | NacionalvSp BragaPrimeira Liga · Portugal | 2–3 | Primeira Liga · Portugal |
| 2016-01-17 | GianninavAEKSuper League · Greece | 0–2 | Super League · Greece |
| 2016-01-17 | PueblavMonterreyLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2016-01-17 | GentvAnderlechtPro League · Belgium | 2–0 | Pro League · Belgium |
| 2016-01-17 | ChievovEmpoliSerie A · Italy | 1–1 | Serie A · Italy |
| 2016-01-17 | Las PalmasvAth MadridLa Liga · Spain | 0–3 | La Liga · Spain |
| 2016-01-17 | GironavPonferradinaLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2016-01-17 | GuimaraesvPortoPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2016-01-17 | Real MadridvSp GijonLa Liga · Spain | 5–1 | La Liga · Spain |
| 2016-01-17 | ValenciavVallecanoLa Liga · Spain | 2–2 | La Liga · Spain |
| 2016-01-17 | LeganesvMirandesLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2016-01-17 | Den HaagvAjaxEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2016-01-17 | RizesporvGenclerbirligiSüper Lig · Turkey | 2–3 | Süper Lig · Turkey |
| 2016-01-17 | BursasporvTrabzonsporSüper Lig · Turkey | 4–2 | Süper Lig · Turkey |
| 2016-01-17 | AlavesvGimnasticLa Liga 2 · Spain | 1–3 | La Liga 2 · Spain |
| 2016-01-17 | CaenvMarseilleLigue 1 · France | 1–3 | Ligue 1 · France |
| 2016-01-17 | Ross CountyvAberdeenPremiership · Scotland | 2–3 | Premiership · Scotland |
| 2016-01-17 | CarpivSampdoriaSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-01-17 | BolognavLazioSerie A · Italy | 2–2 | Serie A · Italy |
| 2016-01-17 | MilanvFiorentinaSerie A · Italy | 2–0 | Serie A · Italy |
| 2016-01-17 | UNAM PumasvTolucaLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2016-01-17 | OxfordvBristol RvsLeague Two · England | 1–2 | League Two · England |
| 2016-01-17 | St EtiennevLyonLigue 1 · France | 1–0 | Ligue 1 · France |
| 2016-01-17 | GenoavPalermoSerie A · Italy | 4–0 | Serie A · Italy |
| 2016-01-17 | Asteras TripolisvKallonisSuper League · Greece | 3–1 | Super League · Greece |
| 2016-01-17 | AlmeriavCordobaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2016-01-16 | HeartsvMotherwellPremiership · Scotland | 6–0 | Premiership · Scotland |
| 2016-01-16 | CoventryvBurtonLeague One · England | 0–2 | League One · England |