| 2022-01-25 | WrexhamvGrimsbyNational League · England | 1–0 | National League · England |
| 2022-01-25 | WealdstonevNotts CountyNational League · England | 0–0 | National League · England |
| 2022-01-25 | ScunthorpevBristol RvsLeague Two · England | 2–3 | League Two · England |
| 2022-01-25 | ElginvKelty HeartsLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2022-01-25 | AntwerpvSt TruidenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2022-01-25 | Dover AthleticvEastleighNational League · England | 1–0 | National League · England |
| 2022-01-25 | AldershotvSouthendNational League · England | 1–1 | National League · England |
| 2022-01-25 |  Moroccov MalawiAfrican Cup of Nations | 2–1 | African Cup of Nations |
| 2022-01-25 | StockportvMaidenheadNational League · England | 3–0 | National League · England |
| 2022-01-25 |  Senegalv Cape VerdeAfrican Cup of Nations | 2–0 | African Cup of Nations |
| 2022-01-25 | Fleetwood TownvPlymouthLeague One · England | 3–3 | League One · England |
| 2022-01-24 | Santos LagunavNecaxaLiga MX · Mexico | 1–4 | Liga MX · Mexico |
| 2022-01-24 |  Guineav GambiaAfrican Cup of Nations | 0–1 | African Cup of Nations |
| 2022-01-24 | Asteras TripolisvApollonSuper League · Greece | 1–0 | Super League · Greece |
| 2022-01-24 | Farul ConstantavU Craiova 1948Superliga · Romania | 3–2 | Superliga · Romania |
| 2022-01-24 | CaenvAjaccioLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-01-24 | FC BotosanivSepsi Sf. GheorgheSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-01-24 |  Cameroonv ComorosAfrican Cup of Nations | 2–1 | African Cup of Nations |
| 2022-01-24 | BlackburnvMiddlesbroughChampionship · England | 1–0 | Championship · England |
| 2022-01-24 | Sociedad BvCartagenaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-01-24 | AlmeriavEibarLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2022-01-23 | MiovenivAcademica ClinceniSuperliga · Romania | 3–1 | Superliga · Romania |
| 2022-01-23 | HannovervDresden2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-01-23 | KasimpasavKayserisporSüper Lig · Turkey | 3–1 | Süper Lig · Turkey |
| 2022-01-23 | Crystal PalacevLiverpoolPremier League · England | 1–3 | Premier League · England |
| 2022-01-23 | NijmegenvFeyenoordEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2022-01-23 |  Burkina Fasov GabonAfrican Cup of Nations | 1–1 p | African Cup of Nations |
| 2022-01-23 | AltayvKonyasporSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2022-01-23 | VicenzavCittadellaSerie B · Italy | 3–3 | Serie B · Italy |
| 2022-01-23 | FCSBvCFR ClujSuperliga · Romania | 3–3 | Superliga · Romania |
| 2022-01-23 | MetzvNiceLigue 1 · France | 0–2 | Ligue 1 · France |
| 2022-01-23 | RegensburgvHolstein Kiel2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-01-23 | AlcorconvMirandesLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-01-23 | MilanvJuventusSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-01-23 | AlavesvBarcelonaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-01-23 | MaritimovBelenensesPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-01-23 | LeccevCremoneseSerie B · Italy | 2–1 | Serie B · Italy |
| 2022-01-23 | GiresunsporvAlanyasporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2022-01-23 | SociedadvGetafeLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-01-23 | Paris SGvReimsLigue 1 · France | 4–0 | Ligue 1 · France |
| 2022-01-23 | UTA AradvGaz Metan MediasSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-01-23 | AngersvTroyesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2022-01-23 | Sparta RotterdamvUtrechtEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2022-01-23 | AntalyasporvGaziantepSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-01-23 | MonterreyvCruz AzulLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2022-01-23 | LeicestervBrightonPremier League · England | 1–1 | Premier League · England |
| 2022-01-23 | Cercle BruggevWaregemPro League · Belgium | 3–1 | Pro League · Belgium |
| 2022-01-23 | PortovFamalicaoPrimeira Liga · Portugal | 3–1 | Primeira Liga · Portugal |
| 2022-01-23 | HuescavPonferradinaLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2022-01-23 | CagliarivFiorentinaSerie A · Italy | 1–1 | Serie A · Italy |