| 2018-01-20 | AldershotvEbbsfleetNational League · England | 0–0 | National League · England |
| 2018-01-20 | Forest GreenvCambridgeLeague Two · England | 5–2 | League Two · England |
| 2018-01-20 | MainzvStuttgartBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2018-01-20 | Ath MadridvGironaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2018-01-20 | LutonvMorecambeLeague Two · England | 1–0 | League Two · England |
| 2018-01-20 | FyldevMacclesfieldNational League · England | 6–0 | National League · England |
| 2018-01-20 | LarisavAEKSuper League · Greece | 0–0 | Super League · Greece |
| 2018-01-20 | OxfordvBuryLeague One · England | 1–2 | League One · England |
| 2018-01-20 | ArsenalvCrystal PalacePremier League · England | 4–1 | Premier League · England |
| 2018-01-20 | ReadingvBrentfordChampionship · England | 0–1 | Championship · England |
| 2018-01-20 | Bristol RvsvBradfordLeague One · England | 3–1 | League One · England |
| 2018-01-20 | NorthamptonvMilton Keynes DonsLeague One · England | 2–1 | League One · England |
| 2018-01-20 | FulhamvBurtonChampionship · England | 6–0 | Championship · England |
| 2018-01-20 | M'gladbachvAugsburgBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2018-01-20 | BarnetvLincolnLeague Two · England | 1–1 | League Two · England |
| 2018-01-20 | TroyesvLilleLigue 1 · France | 1–0 | Ligue 1 · France |
| 2018-01-20 | Sheffield WedsvCardiffChampionship · England | 0–0 | Championship · England |
| 2018-01-20 | OostendevKortrijkPro League · Belgium | 2–1 | Pro League · Belgium |
| 2018-01-20 | MansfieldvCheltenhamLeague Two · England | 3–2 | League Two · England |
| 2018-01-20 | EmpolivTernanaSerie B · Italy | 2–1 | Serie B · Italy |
| 2018-01-20 | ChestervGatesheadNational League · England | 1–3 | National League · England |
| 2018-01-20 | CesenavBariSerie B · Italy | 1–1 | Serie B · Italy |
| 2018-01-20 | Notts CountyvExeterLeague Two · England | 1–2 | League Two · England |
| 2018-01-20 | VillarrealvLevanteLa Liga · Spain | 2–1 | La Liga · Spain |
| 2018-01-20 | StevenagevCarlisleLeague Two · England | 0–0 | League Two · England |
| 2018-01-20 | LeicestervWatfordPremier League · England | 2–0 | Premier League · England |
| 2018-01-20 | CremonesevParmaSerie B · Italy | 1–0 | Serie B · Italy |
| 2018-01-20 | ColchestervGrimsbyLeague Two · England | 1–1 | League Two · England |
| 2018-01-20 | ValladolidvSevilla BLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2018-01-20 | AccringtonvPort ValeLeague Two · England | 3–2 | League Two · England |
| 2018-01-20 | QueretarovTigres UANLLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2018-01-20 | WolfsburgvEin FrankfurtBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2018-01-20 | OviedovAlmeriaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2018-01-20 | Boreham WoodvDover AthleticNational League · England | 2–3 | National League · England |
| 2018-01-20 | HartlepoolvWrexhamNational League · England | 0–2 | National League · England |
| 2018-01-20 | FenerbahcevGoztepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2018-01-20 | SunderlandvHullChampionship · England | 1–0 | Championship · England |
| 2018-01-20 | FreiburgvRB LeipzigBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2018-01-20 | NantesvBordeauxLigue 1 · France | 0–1 | Ligue 1 · France |
| 2018-01-20 | ZwollevNAC BredaEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2018-01-20 | AtlasvTolucaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2018-01-20 | Fleetwood TownvBlackburnLeague One · England | 1–2 | League One · England |
| 2018-01-20 | MaritimovBelenensesPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2018-01-20 | MechelenvWaregemPro League · Belgium | 0–2 | Pro League · Belgium |
| 2018-01-20 | MontpelliervToulouseLigue 1 · France | 2–1 | Ligue 1 · France |
| 2018-01-20 | WolvesvNott'm ForestChampionship · England | 0–2 | Championship · England |
| 2018-01-20 | RodavTwenteEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2018-01-20 | FrosinonevPro VercelliSerie B · Italy | 4–0 | Serie B · Italy |
| 2018-01-20 | StandardvEupenPro League · Belgium | 3–2 | Pro League · Belgium |
| 2018-01-20 | HoffenheimvLeverkusenBundesliga · Germany | 1–4 | Bundesliga · Germany |