| 2021-02-14 | LuzernvVaduzSuper League · Switzerland | 4–0 | Super League · Switzerland |
| 2021-02-14 | Virtus EntellavFrosinoneSerie B · Italy | 2–3 | Serie B · Italy |
| 2021-02-14 | RomavUdineseSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-02-14 | ZurichvBaselSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-02-14 | OdensevAarhusSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2021-02-14 | VejlevNordsjaellandSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-02-14 | FeyenoordvWillem IIEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2021-02-14 | AngersvNantesLigue 1 · France | 1–3 | Ligue 1 · France |
| 2021-02-14 | West BromvMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2021-02-14 | Real MadridvValenciaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-02-14 | GetafevSociedadLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-02-14 | GalatasarayvKasimpasaSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-02-14 | CrotonevSassuoloSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-02-14 | LASKvSturm GrazBundesliga · Austria | 2–0 | Bundesliga · Austria |
| 2021-02-14 | LuganovYoung BoysSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2021-02-14 | ReggianavAscoliSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-02-14 | SampdoriavFiorentinaSerie A · Italy | 2–1 | Serie A · Italy |
| 2021-02-14 | AalborgvRanders FCSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2021-02-14 | PalmeirasvFortalezaSerie A · Brazil | 3–0 | Serie A · Brazil |
| 2021-02-14 | BrentfordvBarnsleyChampionship · England | 0–2 | Championship · England |
| 2021-02-14 | IntervLazioSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-02-14 | Ein FrankfurtvFC KolnBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2021-02-14 | MallorcavEspanolLa Liga 2 · Spain | 1–2 | La Liga 2 · Spain |
| 2021-02-14 | UtrechtvVVV VenloEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-02-14 | St JohnstonevCelticPremiership · Scotland | 1–2 | Premiership · Scotland |
| 2021-02-14 | OxfordvWiganLeague One · England | 2–1 | League One · England |
| 2021-02-14 | LillevBrestLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-02-14 | Athletico-PRvAtletico GOSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-02-14 | RiedvSt. PoltenBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-02-14 | OFI CretevVolos NFCSuper League · Greece | 1–2 | Super League · Greece |
| 2021-02-14 | BordeauxvMarseilleLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-02-14 | BresciavChievoSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-02-14 | MidtjyllandvHorsensSuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-02-14 | Poli IasivAstraSuperliga · Romania | 2–3 | Superliga · Romania |
| 2021-02-14 | VillarrealvBetisLa Liga · Spain | 1–2 | La Liga · Spain |
| 2021-02-14 | LincolnvAccringtonLeague One · England | 2–2 | League One · England |
| 2021-02-14 | PortimonensevGil VicentePrimeira Liga · Portugal | 4–1 | Primeira Liga · Portugal |
| 2021-02-14 | MetzvStrasbourgLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-02-14 | DijonvNimesLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-02-14 | AlcorconvLogronesLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-02-14 | EvertonvFulhamPremier League · England | 0–2 | Premier League · England |
| 2021-02-14 | LeganesvAlbaceteLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-02-14 | TolucavUNAM PumasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-02-14 | RennesvSt EtienneLigue 1 · France | 0–2 | Ligue 1 · France |
| 2021-02-14 | ArisvPanetolikosSuper League · Greece | 0–0 | Super League · Greece |
| 2021-02-14 | Austria ViennavHartbergBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-02-14 | NurnbergvSt Pauli2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-02-14 | AZ AlkmaarvHeerenveenEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-02-14 | BochumvBraunschweig2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2021-02-14 | StandardvAntwerpPro League · Belgium | 1–1 | Pro League · Belgium |