| 2021-11-28 | LeicestervWatfordPremier League · England | 4–2 | Premier League · England |
| 2021-11-28 | HalmstadvHammarbyAllsvenskan · Sweden | 0–0 | Allsvenskan · Sweden |
| 2021-11-28 | ViborgvSonderjyskeDanish Superliga · Denmark | 1–1 | Danish Superliga · Denmark |
| 2021-11-28 | KristiansundvVikingEliteserien · Norway | 2–3 | Eliteserien · Norway |
| 2021-11-28 | EspanolvSociedadLaLiga · Spain | 1–0 | LaLiga · Spain |
| 2021-11-28 | NapolivLazioSerie A · Italy | 4–0 | Serie A · Italy |
| 2021-11-28 | IpswichvCreweLeague One · England | 2–1 | League One · England |
| 2021-11-28 | Man CityvWest HamPremier League · England | 2–1 | Premier League · England |
| 2021-11-28 | GenkvClub BruggePro League · Belgium | 2–3 | Pro League · Belgium |
| 2021-11-28 | RomavTorinoSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-11-28 | SivassporvHataysporSüper Lig · Türkiye | 4–0 | Süper Lig · Türkiye |
| 2021-11-28 | BrondbyvRanders FCDanish Superliga · Denmark | 1–0 | Danish Superliga · Denmark |
| 2021-11-28 | Univ. CraiovavFCSBLiga I · Romania | 2–3 | Liga I · Romania |
| 2021-11-28 | SpeziavBolognaSerie A · Italy | 0–1 | Serie A · Italy |
| 2021-11-28 | AntwerpvOostendePro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-11-28 | Rubin KazanvDynamo MoscowRussian Premier League · Russia | 2–3 | Russian Premier League · Russia |
| 2021-11-27 | Schalke 04vSandhausen2. Bundesliga · Germany | 5–2 | 2. Bundesliga · Germany |
| 2021-11-27 | Sanfrecce HiroshimavFC TokyoJ1 League · Japan | 1–2 | J1 League · Japan |
| 2021-11-27 | LillestromvStromsgodsetEliteserien · Norway | 4–1 | Eliteserien · Norway |
| 2021-11-27 | CosenzavSpalSerie B · Italy | 0–1 | Serie B · Italy |
| 2021-11-27 | LutonvCardiffChampionship · England | 1–2 | Championship · England |
| 2021-11-27 | HerthavAugsburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-11-27 | ValenciavVallecanoLaLiga · Spain | 1–1 | LaLiga · Spain |
| 2021-11-27 | AltachvTirolAustrian Bundesliga · Austria | 0–3 | Austrian Bundesliga · Austria |
| 2021-11-27 | Crawley TownvMansfieldLeague Two · England | 1–2 | League Two · England |
| 2021-11-27 | AltrinchamvSouthendNational League · England | 1–2 | National League · England |
| 2021-11-27 | Port ValevHartlepoolLeague Two · England | 2–0 | League Two · England |
| 2021-11-27 | WolfsburgvDortmundBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2021-11-27 | Kawasaki FrontalevGamba OsakaJ1 League · Japan | 4–1 | J1 League · Japan |
| 2021-11-27 | Slask WroclawvStal MielecEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-11-27 | WrexhamvBromleyNational League · England | 2–0 | National League · England |
| 2021-11-27 | RizesporvKayserisporSüper Lig · Türkiye | 1–0 | Süper Lig · Türkiye |
| 2021-11-27 | SuttonvBarrowLeague Two · England | 1–0 | League Two · England |
| 2021-11-27 | BochumvFreiburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-11-27 | A. KlagenfurtvSalzburgAustrian Bundesliga · Austria | 2–1 | Austrian Bundesliga · Austria |
| 2021-11-27 | AlavesvCeltaLaLiga · Spain | 1–2 | LaLiga · Spain |
| 2021-11-27 | CarlislevWalsallLeague Two · England | 1–0 | League Two · England |
| 2021-11-27 | SwanseavReadingChampionship · England | 2–3 | Championship · England |
| 2021-11-27 | FC KolnvM'gladbachBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2021-11-27 | HeartsvSt MirrenPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2021-11-27 | NicevMetzLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-11-27 | Avispa FukuokavVegalta SendaiJ1 League · Japan | 2–2 | J1 League · Japan |
| 2021-11-27 | VillarrealvBarcelonaLaLiga · Spain | 1–3 | LaLiga · Spain |
| 2021-11-27 | FC Rapid BucurestivMioveniLiga I · Romania | 1–1 | Liga I · Romania |
| 2021-11-27 | NorthamptonvLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2021-11-27 | ValladolidvCartagenaLaLiga 2 · Spain | 2–0 | LaLiga 2 · Spain |
| 2021-11-27 | Cerezo OsakavNagoya GrampusJ1 League · Japan | 2–1 | J1 League · Japan |
| 2021-11-27 | Talleres CordobavAldosiviLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2021-11-27 | AFC WimbledonvFleetwood TownLeague One · England | 2–2 | League One · England |
| 2021-11-27 | Greuther FurthvHoffenheimBundesliga · Germany | 3–6 | Bundesliga · Germany |