| 2021-02-17 | CoventryvNorwichChampionship · England | 0–2 | Championship · England |
| 2021-02-17 | EvertonvMan CityPremier League · England | 1–3 | Premier League · England |
| 2021-02-17 | GuimaraesvFarensePrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2021-02-17 | SantosvCorinthiansSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-02-17 | CelticvAberdeenPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-02-17 | LuganovServetteSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-02-17 | OostendevGenkPro League · Belgium | 3–1 | Pro League · Belgium |
| 2021-02-17 | BournemouthvRotherhamChampionship · England | 1–0 | Championship · England |
| 2021-02-17 | BarnsleyvBlackburnChampionship · England | 2–1 | Championship · England |
| 2021-02-17 | Inverness CvQueen of SthChampionship · Scotland | 0–1 | Championship · Scotland |
| 2021-02-17 | CoritibavPalmeirasSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-02-17 | St. GallenvLuzernSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-02-17 | DoncastervAccringtonLeague One · England | 0–1 | League One · England |
| 2021-02-17 | BurnleyvFulhamPremier League · England | 1–1 | Premier League · England |
| 2021-02-17 | MarseillevNiceLigue 1 · France | 3–2 | Ligue 1 · France |
| 2021-02-17 | SwanseavNott'm ForestChampionship · England | 1–0 | Championship · England |
| 2021-02-17 | WiganvHullLeague One · England | 0–5 | League One · England |
| 2021-02-17 | Waasland-BeverenvEupenPro League · Belgium | 1–0 | Pro League · Belgium |
| 2021-02-17 | QPRvBrentfordChampionship · England | 2–1 | Championship · England |
| 2021-02-17 | LeganesvAlmeriaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-02-17 | LevantevAth MadridLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-02-17 | MansfieldvBoltonLeague Two · England | 2–3 | League Two · England |
| 2021-02-17 | MillwallvBirminghamChampionship · England | 2–0 | Championship · England |
| 2021-02-16 | WalsallvCheltenhamLeague Two · England | 1–2 | League Two · England |
| 2021-02-16 | MaidenheadvStockportNational League · England | 0–0 | National League · England |
| 2021-02-16 | SalfordvBarrowLeague Two · England | 1–0 | League Two · England |
| 2021-02-16 | EastleighvHartlepoolNational League · England | 2–1 | National League · England |
| 2021-02-16 | Newport CountyvExeterLeague Two · England | 1–1 | League Two · England |
| 2021-02-16 | HarrogatevCarlisleLeague Two · England | 1–0 | League Two · England |
| 2021-02-16 | BradfordvMorecambeLeague Two · England | 2–1 | League Two · England |
| 2021-02-16 | WycombevDerbyChampionship · England | 1–2 | Championship · England |
| 2021-02-16 | Bristol RvsvPortsmouthLeague One · England | 3–1 | League One · England |
| 2021-02-16 | Bristol CityvReadingChampionship · England | 0–2 | Championship · England |
| 2021-02-16 | MiddlesbroughvHuddersfieldChampionship · England | 2–1 | Championship · England |
| 2021-02-16 | LutonvCardiffChampionship · England | 0–2 | Championship · England |
| 2021-02-16 | PachucavAtlasLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-02-16 | Boreham WoodvYeovilNational League · England | 2–3 | National League · England |
| 2021-02-16 | IndependientevLanusCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-02-16 | Forest GreenvOldhamLeague Two · England | 4–3 | League Two · England |
| 2021-02-16 | TondelavMaritimoPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-02-16 | Crawley TownvStevenageLeague Two · England | 0–1 | League Two · England |
| 2021-02-16 | PrestonvWatfordChampionship · England | 0–1 | Championship · England |
| 2021-02-16 | GillinghamvPeterboroLeague One · England | 1–3 | League One · England |
| 2021-02-16 | Dag and RedvBromleyNational League · England | 1–0 | National League · England |
| 2021-02-16 | WrexhamvWokingNational League · England | 2–0 | National League · England |
| 2021-02-16 | AldershotvSolihullNational League · England | 1–3 | National League · England |
| 2021-02-16 | FC ArgesvSepsi Sf. GheorgheSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-02-16 | Kings LynnvNotts CountyNational League · England | 0–1 | National League · England |
| 2021-02-16 | IpswichvNorthamptonLeague One · England | 0–0 | League One · England |
| 2021-02-16 | BlackpoolvRochdaleLeague One · England | 1–0 | League One · England |