| 2021-02-20 | FreiburgvUnion BerlinBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-02-20 | HeartsvMortonChampionship · Scotland | 1–1 | Championship · Scotland |
| 2021-02-20 | ScunthorpevHarrogateLeague Two · England | 3–1 | League Two · England |
| 2021-02-20 | SouthamptonvChelseaPremier League · England | 1–1 | Premier League · England |
| 2021-02-20 | FulhamvSheffield UnitedPremier League · England | 1–0 | Premier League · England |
| 2021-02-20 | AtromitosvLarisaSuper League · Greece | 1–1 | Super League · Greece |
| 2021-02-20 | Sheffield WedsvBirminghamChampionship · England | 0–1 | Championship · England |
| 2021-02-20 | BarrowvMorecambeLeague Two · England | 1–2 | League Two · England |
| 2021-02-20 | BurtonvSunderlandLeague One · England | 0–3 | League One · England |
| 2021-02-20 | GillinghamvBristol RvsLeague One · England | 2–0 | League One · England |
| 2021-02-20 | PodbeskidzievJagielloniaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2021-02-20 | PaderbornvSandhausen2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-02-20 | BresciavCremoneseSerie B · Italy | 1–2 | Serie B · Italy |
| 2021-02-20 | AltrinchamvBoreham WoodNational League · England | 2–3 | National League · England |
| 2021-02-20 | ValenciavCeltaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2021-02-20 | TirolvSt. PoltenBundesliga · Austria | 0–1 | Bundesliga · Austria |
| 2021-02-20 | SuttonvWealdstoneNational League · England | 4–1 | National League · England |
| 2021-02-20 | Ath MadridvLevanteLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-02-20 | EupenvOostendePro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-02-20 | Milton Keynes DonsvNorthamptonLeague One · England | 4–3 | League One · England |
| 2021-02-20 | Sp LisbonvPortimonensePrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-02-20 | Paris FCvChateaurouxLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-02-20 | BaselvLausanneSuper League · Switzerland | 0–0 | Super League · Switzerland |
| 2021-02-20 | HartbergvRiedBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2021-02-20 | QPRvBournemouthChampionship · England | 2–1 | Championship · England |
| 2021-02-20 | TorquayvHalifaxNational League · England | 2–3 | National League · England |
| 2021-02-20 | DundeevQueen of SthChampionship · Scotland | 2–3 | Championship · Scotland |
| 2021-02-20 | OsnabruckvHeidenheim2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2021-02-20 | NiortvPau FCLigue 2 · France | 2–1 | Ligue 2 · France |
| 2021-02-20 | BarnetvWokingNational League · England | 0–2 | National League · England |
| 2021-02-20 | Las PalmasvCartagenaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-02-20 | EastleighvStockportNational League · England | 1–0 | National League · England |
| 2021-02-20 | LanusvDefensa y JusticiaCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2021-02-20 | RodezvToulouseLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-02-20 | VicenzavSpalSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-02-20 | Le HavrevDunkerqueLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-02-20 | WeymouthvSolihullNational League · England | 0–0 | National League · England |
| 2021-02-20 | LaziovSampdoriaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-02-20 | HartlepoolvYeovilNational League · England | 2–1 | National League · England |
| 2021-02-20 | Fleetwood TownvCharltonLeague One · England | 1–1 | League One · England |
| 2021-02-20 | Crawley TownvColchesterLeague Two · England | 1–0 | League Two · England |
| 2021-02-20 | TranmerevOldhamLeague Two · England | 2–2 | League Two · England |
| 2021-02-20 | Godoy CruzvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2021-02-20 | ElchevEibarLa Liga · Spain | 1–0 | La Liga · Spain |
| 2021-02-20 | Austria ViennavAltachBundesliga · Austria | 5–1 | Bundesliga · Austria |
| 2021-02-20 | FC KolnvStuttgartBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-02-20 | SalfordvCarlisleLeague Two · England | 1–1 | League Two · England |
| 2021-02-20 | DenizlisporvGenclerbirligiSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2021-02-20 | AyrvInverness CChampionship · Scotland | 0–2 | Championship · Scotland |
| 2021-02-20 | Notts CountyvChesterfieldNational League · England | 0–1 | National League · England |