| 2021-02-20 | IpswichvOxfordLeague One · England | 0–0 | League One · England |
| 2021-02-20 | JuarezvMazatlan FCLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-02-20 | VVV VenlovAZ AlkmaarEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2021-02-20 | Waasland-BeverenvCharleroiPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-02-20 | St EtiennevReimsLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-02-20 | Leyton OrientvPort ValeLeague Two · England | 1–1 | League Two · England |
| 2021-02-20 | SouthendvBoltonLeague Two · England | 0–1 | League Two · England |
| 2021-02-20 | WiganvLincolnLeague One · England | 1–2 | League One · England |
| 2021-02-20 | Sepsi Sf. GheorghevAcademica ClinceniSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-02-20 | SassuolovBolognaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-02-20 | AscolivSalernitanaSerie B · Italy | 0–2 | Serie B · Italy |
| 2021-02-20 | St MirrenvLivingstonPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-02-20 | DoncastervHullLeague One · England | 3–3 | League One · England |
| 2021-02-20 | LegiavWisla PlockEkstraklasa · Poland | 5–2 | Ekstraklasa · Poland |
| 2021-02-20 | NancyvGrenobleLigue 2 · France | 1–2 | Ligue 2 · France |
| 2021-02-20 | StokevLutonChampionship · England | 3–0 | Championship · England |
| 2021-02-20 | ReadingvMiddlesbroughChampionship · England | 0–2 | Championship · England |
| 2021-02-20 | Arsenal SarandivBanfieldCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2021-02-20 | BelenensesvNacionalPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-02-20 | AjacciovClermontLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-02-20 | Gil VicentevSanta ClaraPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-02-20 | FCSBvChindia TargovisteSuperliga · Romania | 1–0 | Superliga · Romania |
| 2021-02-20 | Nott'm ForestvBlackburnChampionship · England | 1–0 | Championship · England |
| 2021-02-20 | Schalke 04vDortmundBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2021-02-20 | MotherwellvSt JohnstonePremiership · Scotland | 0–3 | Premiership · Scotland |
| 2021-02-20 | PisavEmpoliSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-20 | Racing ClubvAldosiviCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2021-02-20 | ValladolidvReal MadridLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-02-20 | CittadellavReggianaSerie B · Italy | 0–3 | Serie B · Italy |
| 2021-02-20 | AEKvAsteras TripolisSuper League · Greece | 2–2 | Super League · Greece |
| 2021-02-20 | EspanolvSabadellLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-02-20 | ArbroathvRaith RvsChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-02-20 | AldershotvWrexhamNational League · England | 3–0 | National League · England |
| 2021-02-20 | RochdalevPlymouthLeague One · England | 0–0 | League One · England |
| 2021-02-20 | MillwallvWycombeChampionship · England | 0–0 | Championship · England |
| 2021-02-20 | ChamblyvAuxerreLigue 2 · France | 0–1 | Ligue 2 · France |
| 2021-02-20 | NorwichvRotherhamChampionship · England | 1–0 | Championship · England |
| 2021-02-20 | GenoavVeronaSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-02-20 | NantesvMarseilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-02-20 | MansfieldvCambridgeLeague Two · England | 0–3 | League Two · England |
| 2021-02-20 | FC EmmenvZwolleEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2021-02-20 | BurnleyvWest BromPremier League · England | 0–0 | Premier League · England |
| 2021-02-20 | Ein FrankfurtvBayern MunichBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-02-20 | LiverpoolvEvertonPremier League · England | 0–2 | Premier League · England |
| 2021-02-20 | CardiffvPrestonChampionship · England | 4–0 | Championship · England |
| 2021-02-20 | VaduzvSt. GallenSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2021-02-20 | SwindonvCreweLeague One · England | 2–1 | League One · England |
| 2021-02-20 | Lechia GdanskvGornik Z.Ekstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2021-02-20 | CheltenhamvBradfordLeague Two · England | 0–2 | League Two · England |
| 2021-02-20 | VeneziavVirtus EntellaSerie B · Italy | 3–2 | Serie B · Italy |