| 2016-01-31 | Tigres UANLvClub LeonLiga MX · Mexico | 3–1 | Liga MX · Mexico |
| 2016-01-30 | BarcelonavAth MadridLa Liga · Spain | 2–1 | La Liga · Spain |
| 2016-01-30 | East FifevClydeLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2016-01-30 | Crawley TownvMansfieldLeague Two · England | 0–1 | League Two · England |
| 2016-01-30 | HartlepoolvExeterLeague Two · England | 0–2 | League Two · England |
| 2016-01-30 | ComovVicenzaSerie B · Italy | 1–1 | Serie B · Italy |
| 2016-01-30 | RotherhamvCharltonChampionship · England | 1–4 | Championship · England |
| 2016-01-30 | Oud-Heverlee LeuvenvStandardPro League · Belgium | 0–2 | Pro League · Belgium |
| 2016-01-30 | Cruz AzulvChiapasLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2016-01-30 | Werder BremenvHerthaBundesliga · Germany | 3–3 | Bundesliga · Germany |
| 2016-01-30 | CarpivPalermoSerie A · Italy | 1–1 | Serie A · Italy |
| 2016-01-30 | Bristol CityvBirminghamChampionship · England | 0–0 | Championship · England |
| 2016-01-30 | StuttgartvHamburgBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2016-01-30 | PlymouthvWycombeLeague Two · England | 0–1 | League Two · England |
| 2016-01-30 | GatesheadvGrimsbyNational League · England | 1–0 | National League · England |
| 2016-01-30 | VillarrealvGranadaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2016-01-30 | StranraervBrechinLeague One · Scotland | 2–0 | League One · Scotland |
| 2016-01-30 | WokingvBarrowNational League · England | 2–2 | National League · England |
| 2016-01-30 | PSV EindhovenvGraafschapEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2016-01-30 | DumbartonvLivingstonChampionship · Scotland | 1–0 | Championship · Scotland |
| 2016-01-30 | RomavFrosinoneSerie A · Italy | 3–1 | Serie A · Italy |
| 2016-01-30 | GenkvKortrijkPro League · Belgium | 1–0 | Pro League · Belgium |
| 2016-01-30 | BastiavLyonLigue 1 · France | 1–0 | Ligue 1 · France |
| 2016-01-30 | TranmerevTorquayNational League · England | 2–1 | National League · England |
| 2016-01-30 | ToulousevGuingampLigue 1 · France | 1–2 | Ligue 1 · France |
| 2016-01-30 | YorkvStevenageLeague Two · England | 2–1 | League Two · England |
| 2016-01-30 | BlackpoolvGillinghamLeague One · England | 1–0 | League One · England |
| 2016-01-30 | HalifaxvWelling UnitedNational League · England | 1–1 | National League · England |
| 2016-01-30 | MillwallvCreweLeague One · England | 1–1 | League One · England |
| 2016-01-30 | AlcorconvValladolidLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2016-01-30 | CordobavLeganesLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2016-01-30 | AFC WimbledonvYeovilLeague Two · England | 2–3 | League Two · England |
| 2016-01-30 | CrotonevPerugiaSerie B · Italy | 1–2 | Serie B · Italy |
| 2016-01-30 | NijmegenvAZ AlkmaarEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2016-01-30 | RangersvFalkirkChampionship · Scotland | 1–0 | Championship · Scotland |
| 2016-01-30 | AccringtonvBristol RvsLeague Two · England | 1–0 | League Two · England |
| 2016-01-30 | TernanavModenaSerie B · Italy | 2–1 | Serie B · Italy |
| 2016-01-30 | Le HavrevLensLigue 2 · France | 2–0 | Ligue 2 · France |
| 2016-01-30 | VeracruzvClub TijuanaLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2016-01-30 | HuddersfieldvCardiffChampionship · England | 2–3 | Championship · England |
| 2016-01-30 | AldershotvKidderminsterNational League · England | 1–0 | National League · England |
| 2016-01-30 | EastleighvWrexhamNational League · England | 1–1 | National League · England |
| 2016-01-30 | OviedovAlavesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-01-30 | KilmarnockvHamiltonPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2016-01-30 | AtalantavSassuoloSerie A · Italy | 1–1 | Serie A · Italy |
| 2016-01-30 | VitessevExcelsiorEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2016-01-30 | GetafevAth BilbaoLa Liga · Spain | 0–1 | La Liga · Spain |
| 2016-01-30 | HuescavAlbaceteLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2016-01-30 | WesterlovWaregemPro League · Belgium | 1–2 | Pro League · Belgium |
| 2016-01-30 | EstorilvPortoPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |