| 2022-02-05 | GuingampvAuxerreLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-05 | TrabzonsporvKasimpasaSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2022-02-05 | IntervMilanSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-02-05 | BastiavPau FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-05 | Inverness CvMortonChampionship · Scotland | 0–1 | Championship · Scotland |
| 2022-02-05 | NecaxavPachucaLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2022-02-05 | For SittardvHeerenveenEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2022-02-05 | AltrinchamvWokingNational League · England | 2–2 | National League · England |
| 2022-02-05 | Farul ConstantavChindia TargovisteSuperliga · Romania | 0–1 | Superliga · Romania |
| 2022-02-05 | St JohnstonevDundee UnitedPremiership · Scotland | 0–0 | Premiership · Scotland |
| 2022-02-05 | MorecambevBoltonLeague One · England | 1–1 | League One · England |
| 2022-02-05 | SwanseavBlackburnChampionship · England | 1–0 | Championship · England |
| 2022-02-05 | KortrijkvSt TruidenPro League · Belgium | 1–3 | Pro League · Belgium |
| 2022-02-05 | ToulousevDijonLigue 2 · France | 4–1 | Ligue 2 · France |
| 2022-02-05 | NancyvCaenLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-05 | SwindonvExeterLeague Two · England | 1–2 | League Two · England |
| 2022-02-05 | PeterheadvAlloaLeague One · Scotland | 0–1 | League One · Scotland |
| 2022-02-05 | Pacos FerreiravPortimonensePrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-02-05 | AugsburgvUnion BerlinBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-02-05 | ChesterfieldvDag and RedNational League · England | 2–1 | National League · England |
| 2022-02-05 | HibernianvSt MirrenPremiership · Scotland | 0–1 | Premiership · Scotland |
| 2022-02-05 | YeovilvSolihullNational League · England | 0–0 | National League · England |
| 2022-02-05 | GaziantepvSivassporSüper Lig · Turkey | 5–1 | Süper Lig · Turkey |
| 2022-02-05 | BielefeldvM'gladbachBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-02-05 | Univ. CraiovavCFR ClujSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-05 | StockportvDover AthleticNational League · England | 1–0 | National League · England |
| 2022-02-05 | PanetolikosvGianninaSuper League · Greece | 0–1 | Super League · Greece |
| 2022-02-05 | RotherhamvAccringtonLeague One · England | 1–0 | League One · England |
| 2022-02-05 | LivingstonvAberdeenPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2022-02-05 | Raith RvsvHamiltonChampionship · Scotland | 0–0 | Championship · Scotland |
| 2022-02-05 | Crawley TownvStevenageLeague Two · England | 2–2 | League Two · England |
| 2022-02-05 | AyrvDunfermlineChampionship · Scotland | 1–1 | Championship · Scotland |
| 2022-02-05 | CrotonevCittadellaSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-02-05 | Cove RangersvAirdrie UtdLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-02-05 | Sociedad BvLugoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-02-05 | SandhausenvErzgebirge Aue2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-02-05 | AlessandriavPisaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-05 | MaidenheadvEastleighNational League · England | 2–2 | National League · England |
| 2022-02-05 | UtrechtvCambuurEredivisie · Netherlands | 3–2 | Eredivisie · Netherlands |
| 2022-02-05 | AntwerpvSt. GilloisePro League · Belgium | 0–2 | Pro League · Belgium |
| 2022-02-05 | CeltavVallecanoLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-02-05 | Quevilly RouenvGrenobleLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-02-05 | Piast GliwicevPogon SzczecinEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2022-02-05 | TorquayvWrexhamNational League · England | 1–0 | National League · England |
| 2022-02-05 | Forest GreenvNewport CountyLeague Two · England | 2–0 | League Two · England |
| 2022-02-05 | MontrosevDumbartonLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-02-05 | GrasshoppersvZurichSuper League · Switzerland | 1–3 | Super League · Switzerland |
| 2022-02-05 | FiorentinavLazioSerie A · Italy | 0–3 | Serie A · Italy |
| 2022-02-05 | ScunthorpevOldhamLeague Two · England | 0–1 | League Two · England |
| 2022-02-05 | Leyton OrientvColchesterLeague Two · England | 0–1 | League Two · England |