| 2021-02-21 | GironavCastellonLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2021-02-21 | MontpelliervRennesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-02-21 | TwentevFeyenoordEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-02-21 | GaziantepvAntalyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-02-21 | Erzurum BBvHataysporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2021-02-21 | LeccevCosenzaSerie B · Italy | 3–1 | Serie B · Italy |
| 2021-02-21 | AtlasvClub AmericaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-02-21 | Pacos FerreiravGuimaraesPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2021-02-21 | AtalantavNapoliSerie A · Italy | 4–2 | Serie A · Italy |
| 2021-02-21 | Man UnitedvNewcastlePremier League · England | 3–1 | Premier League · England |
| 2021-02-21 | ArsenalvMan CityPremier League · England | 0–1 | Premier League · England |
| 2021-02-21 | SivassporvKayserisporSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2021-02-21 | SantosvFluminenseSerie A · Brazil | 1–1 | Serie A · Brazil |
| 2021-02-21 | CorinthiansvVascoSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-02-21 | AarhusvSonderjyskeSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-02-21 | BrondbyvVejleSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-02-21 | Sp BragavTondelaPrimeira Liga · Portugal | 4–2 | Primeira Liga · Portugal |
| 2021-02-21 | AstravDin. BucurestiSuperliga · Romania | 2–0 | Superliga · Romania |
| 2021-02-21 | StrasbourgvAngersLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-02-21 | QueretarovPueblaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-02-21 | PSV EindhovenvVitesseEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2021-02-21 | WaalwijkvHeraclesEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2021-02-21 | OlympiakosvArisSuper League · Greece | 1–1 | Super League · Greece |
| 2021-02-21 | BarcelonavCadizLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-02-21 | Sturm GrazvWolfsberger ACBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2021-02-21 | LugovLogronesLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-02-21 | LuganovLuzernSuper League · Switzerland | 2–3 | Super League · Switzerland |
| 2021-02-21 | PAOKvLamiaSuper League · Greece | 4–0 | Super League · Greece |
| 2021-02-21 | HerthavRB LeipzigBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2021-02-21 | RegginavPordenoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-02-21 | Rio AvevFamalicaoPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2021-02-21 | GianninavOFI CreteSuper League · Greece | 1–0 | Super League · Greece |
| 2021-02-21 | ZaglebievRakowEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-02-21 | Cruz AzulvTolucaLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2021-02-21 | Newport CountyvForest GreenLeague Two · England | 0–2 | League Two · England |
| 2021-02-21 | LorientvLilleLigue 1 · France | 1–4 | Ligue 1 · France |
| 2021-02-21 | HuescavGranadaLa Liga · Spain | 3–2 | La Liga · Spain |
| 2021-02-21 | FortalezavBahiaSerie A · Brazil | 0–4 | Serie A · Brazil |
| 2021-02-21 | MallorcavAlmeriaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-02-21 | Sport RecifevAtletico-MGSerie A · Brazil | 2–3 | Serie A · Brazil |
| 2021-02-21 | River PlatevRosario CentralCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2021-02-21 | GoiasvBragantinoSerie A · Brazil | 0–0 | Serie A · Brazil |
| 2021-02-21 | AnderlechtvKortrijkPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-02-21 | Lech PoznanvSlask WroclawEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-02-21 | RangersvDundee UnitedPremiership · Scotland | 4–1 | Premiership · Scotland |
| 2021-02-21 | AdmiravLASKBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2021-02-21 | FenerbahcevGoztepSüper Lig · Turkey | 0–1 | Süper Lig · Turkey |
| 2021-02-21 | ZurichvSionSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-02-21 | West HamvTottenhamPremier League · England | 2–1 | Premier League · England |
| 2021-02-21 | WaregemvStandardPro League · Belgium | 3–2 | Pro League · Belgium |