| 2022-02-06 | Willem IIvWaalwijkEredivisie · Netherlands | 3–1 | Eredivisie · Netherlands |
| 2022-02-06 | St. GallenvYoung BoysSuper League · Switzerland | 3–3 | Super League · Switzerland |
| 2022-02-06 | QueretarovPueblaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2022-02-06 | LorientvLensLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-02-06 | JuventusvVeronaSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-02-06 | VeneziavNapoliSerie A · Italy | 0–2 | Serie A · Italy |
| 2022-02-06 | FuenlabradavValladolidLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-02-06 | HuescavMirandesLa Liga 2 · Spain | 4–0 | La Liga 2 · Spain |
| 2022-02-06 | MechelenvBeerschot VAPro League · Belgium | 3–2 | Pro League · Belgium |
| 2022-02-06 | TroyesvMetzLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-02-06 | RangersvHeartsPremiership · Scotland | 5–0 | Premiership · Scotland |
| 2022-02-06 | Gil VicentevSanta ClaraPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2022-02-06 | AnderlechtvEupenPro League · Belgium | 4–1 | Pro League · Belgium |
| 2022-02-06 | Real MadridvGranadaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2022-02-06 | PordenonevSpalSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-06 | SampdoriavSassuoloSerie A · Italy | 4–0 | Serie A · Italy |
| 2022-02-06 | RennesvBrestLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-02-06 | AjaxvHeraclesEredivisie · Netherlands | 3–0 | Eredivisie · Netherlands |
| 2022-02-06 | DortmundvLeverkusenBundesliga · Germany | 2–5 | Bundesliga · Germany |
| 2022-02-05 | ShrewsburyvFleetwood TownLeague One · England | 1–1 | League One · England |
| 2022-02-05 | WalsallvNorthamptonLeague Two · England | 0–1 | League Two · England |
| 2022-02-05 | HullvPrestonChampionship · England | 0–1 | Championship · England |
| 2022-02-05 | Werder BremenvKarlsruhe2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-02-05 | StranraervEdinburgh CityLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2022-02-05 | FrosinonevVicenzaSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-02-05 | Sp GijonvEibarLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2022-02-05 | RodezvValenciennesLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-02-05 | BarrowvTranmereLeague Two · England | 1–1 | League Two · England |
| 2022-02-05 | SochauxvAmiensLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-05 | MainzvHoffenheimBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-02-05 | KaragumrukvYeni MalatyasporSüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2022-02-05 | GuimaraesvSp BragaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-02-05 | ArisvVolos NFCSuper League · Greece | 0–2 | Super League · Greece |
| 2022-02-05 | SuttonvBristol RvsLeague Two · England | 1–1 | League Two · England |
| 2022-02-05 | BurnleyvWatfordPremier League · England | 0–0 | Premier League · England |
| 2022-02-05 | OostendevOud-Heverlee LeuvenPro League · Belgium | 1–3 | Pro League · Belgium |
| 2022-02-05 | MallorcavCadizLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-02-05 | St PaulivPaderborn2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-02-05 | BurtonvSheffield WedsLeague One · England | 0–2 | League One · England |
| 2022-02-05 | Notts CountyvGrimsbyNational League · England | 1–2 | National League · England |
| 2022-02-05 | ServettevLausanneSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2022-02-05 | ElchevAlavesLa Liga · Spain | 3–1 | La Liga · Spain |
| 2022-02-05 | NimesvDunkerqueLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-02-05 | FC KolnvFreiburgBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-02-05 | Schalke 04vRegensburg2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-02-05 | ZwollevNijmegenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-02-05 | GironavPonferradinaLa Liga 2 · Spain | 3–0 | La Liga 2 · Spain |
| 2022-02-05 | AldershotvBarnetNational League · England | 1–3 | National League · England |
| 2022-02-05 | ZaragozavMalagaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-02-05 | SunderlandvDoncasterLeague One · England | 1–2 | League One · England |