| 2021-02-22 | Newells Old BoysvBoca JuniorsCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-02-22 | PanetolikosvPanathinaikosSuper League · Greece | 1–0 | Super League · Greece |
| 2021-02-22 | JuventusvCrotoneSerie A · Italy | 3–0 | Serie A · Italy |
| 2021-02-22 | LyngbyvFC CopenhagenSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-02-22 | OsasunavSevillaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-02-22 | BrightonvCrystal PalacePremier League · England | 1–2 | Premier League · England |
| 2021-02-22 | AnkaragucuvRizesporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-02-22 | Piast GliwicevWarta PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-02-22 | ZaragozavAlcorconLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2021-02-22 | MaritimovPortoPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-02-22 | UTA AradvFC BotosaniSuperliga · Romania | 0–0 | Superliga · Romania |
| 2021-02-22 | Tigres UANLvClub TijuanaLiga MX · Mexico | 3–2 | Liga MX · Mexico |
| 2021-02-22 | Greuther FurthvHolstein Kiel2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2021-02-22 | GuingampvCaenLigue 2 · France | 2–2 | Ligue 2 · France |
| 2021-02-22 | Botafogo RJvSao PauloSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-02-21 | HoffenheimvWerder BremenBundesliga · Germany | 4–0 | Bundesliga · Germany |
| 2021-02-21 | Young BoysvServetteSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-02-21 | LensvDijonLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-02-21 | AntwerpvSt TruidenPro League · Belgium | 0–0 | Pro League · Belgium |
| 2021-02-21 | NimesvBordeauxLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-02-21 | AjaxvSparta RotterdamEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2021-02-21 | Volos NFCvApollonSuper League · Greece | 2–0 | Super League · Greece |
| 2021-02-21 | SociedadvAlavesLa Liga · Spain | 4–0 | La Liga · Spain |
| 2021-02-21 | BeneventovRomaSerie A · Italy | 0–0 | Serie A · Italy |
| 2021-02-21 | KarlsruhevNurnberg2. Bundesliga · Germany | 0–1 | 2. Bundesliga · Germany |
| 2021-02-21 | LeganesvTenerifeLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-02-21 | SalzburgvSK RapidBundesliga · Austria | 4–2 | Bundesliga · Austria |
| 2021-02-21 | GenkvBeerschot VAPro League · Belgium | 1–2 | Pro League · Belgium |
| 2021-02-21 | HeerenveenvGroningenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-02-21 | AugsburgvLeverkusenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-02-21 | MalagavVallecanoLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2021-02-21 | ParmavUdineseSerie A · Italy | 2–2 | Serie A · Italy |
| 2021-02-21 | Fortuna DusseldorfvHannover2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-02-21 | NicevMetzLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-02-21 | Aston VillavLeicesterPremier League · England | 1–2 | Premier League · England |
| 2021-02-21 | Randers FCvNordsjaellandSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-02-21 | Ross CountyvCelticPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-02-21 | Ath BilbaovVillarrealLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-02-21 | Gaz Metan MediasvCFR ClujSuperliga · Romania | 0–1 | Superliga · Romania |
| 2021-02-21 | FarensevBenficaPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-02-21 | MilanvInterSerie A · Italy | 0–3 | Serie A · Italy |
| 2021-02-21 | UNAM PumasvClub LeonLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-02-21 | Argentinos JrsvPlatenseCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-02-21 | Wurzburger KickersvHamburg2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-02-21 | HorsensvOdenseSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2021-02-21 | Sarmiento JuninvVelez SarsfieldCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2021-02-21 | Flamengo RJvInternacionalSerie A · Brazil | 2–1 | Serie A · Brazil |
| 2021-02-21 | PatronatovIndependienteCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-02-21 | GremiovAthletico-PRSerie A · Brazil | 1–0 | Serie A · Brazil |
| 2021-02-21 | Paris SGv MonacoLigue 1 · France | 0–2 | Ligue 1 · France |