| 2022-02-07 | Radomiak RadomvWisla PlockEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-02-07 | AtlasvSantos LagunaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-02-07 | Tigres UANLvMazatlan FCLiga MX · Mexico | 4–3 | Liga MX · Mexico |
| 2022-02-07 | FC BotosanivDin. BucurestiSuperliga · Romania | 4–0 | Superliga · Romania |
| 2022-02-07 | TondelavBenficaPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2022-02-07 | SalernitanavSpeziaSerie A · Italy | 2–2 | Serie A · Italy |
| 2022-02-07 | Ath BilbaovEspanolLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-02-06 | AtalantavCagliariSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-02-06 | CracoviavLech PoznanEkstraklasa · Poland | 3–3 | Ekstraklasa · Poland |
| 2022-02-06 | FeyenoordvSparta RotterdamEredivisie · Netherlands | 4–0 | Eredivisie · Netherlands |
| 2022-02-06 | BaselvSionSuper League · Switzerland | 3–3 | Super League · Switzerland |
| 2022-02-06 | CartagenavLas PalmasLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2022-02-06 | Warta PoznanvLecznaEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-02-06 | GoztepvAltaySüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2022-02-06 | FCSBvU Craiova 1948Superliga · Romania | 2–2 | Superliga · Romania |
| 2022-02-06 | GroningenvGo Ahead EaglesEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-02-06 | NicevClermontLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-06 | StrasbourgvNantesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-02-06 | Club TijuanavUNAM PumasLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-02-06 | Holstein KielvFortuna Dusseldorf2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2022-02-06 | Club BruggevGentPro League · Belgium | 1–2 | Pro League · Belgium |
| 2022-02-06 | FC ArgesvAcademica ClinceniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-02-06 | TenerifevLeganesLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-02-06 | RakowvWislaEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2022-02-06 | BoavistavVizelaPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2022-02-06 | CremonesevMonzaSerie B · Italy | 3–2 | Serie B · Italy |
| 2022-02-06 | UdinesevTorinoSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-02-06 | AroucavPortoPrimeira Liga · Portugal | 0–2 | Primeira Liga · Portugal |
| 2022-02-06 | BarcelonavAth MadridLa Liga · Spain | 4–2 | La Liga · Spain |
| 2022-02-06 | WolfsburgvGreuther FurthBundesliga · Germany | 4–1 | Bundesliga · Germany |
| 2022-02-06 | Club AmericavAtl. San LuisLiga MX · Mexico | 2–3 | Liga MX · Mexico |
| 2022-02-06 | BetisvVillarrealLa Liga · Spain | 0–2 | La Liga · Spain |
| 2022-02-06 |  Senegalv EgyptAfrican Cup of Nations | 0–0 p | African Cup of Nations |
| 2022-02-06 | GenkvWaregemPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-02-06 | BesiktasvAntalyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-02-06 | DarmstadtvHamburg2. Bundesliga · Germany | 0–5 | 2. Bundesliga · Germany |
| 2022-02-06 | RizesporvAd. DemirsporSüper Lig · Turkey | 1–3 | Süper Lig · Turkey |
| 2022-02-06 | LuganovLuzernSuper League · Switzerland | 2–1 | Super League · Switzerland |
| 2022-02-06 | MotherwellvCelticPremiership · Scotland | 0–4 | Premiership · Scotland |
| 2022-02-06 | LillevParis SGLigue 1 · France | 1–5 | Ligue 1 · France |
| 2022-02-06 | ReimsvBordeauxLigue 1 · France | 5–0 | Ligue 1 · France |
| 2022-02-06 | BolognavEmpoliSerie A · Italy | 0–0 | Serie A · Italy |
| 2022-02-06 | PAOKvPanathinaikosSuper League · Greece | 2–1 | Super League · Greece |
| 2022-02-06 | IonikosvOlympiakosSuper League · Greece | 0–3 | Super League · Greece |
| 2022-02-06 | Sp LisbonvFamalicaoPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-02-06 | AlanyasporvGalatasaraySüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-02-06 | AEKvApollonSuper League · Greece | 3–0 | Super League · Greece |
| 2022-02-06 | AmorebietavOviedoLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-02-06 | ValenciavSociedadLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-02-06 | DresdenvHansa Rostock2. Bundesliga · Germany | 1–4 | 2. Bundesliga · Germany |