| 2022-02-09 | PrestonvHuddersfieldChampionship · England | 0–0 | Championship · England |
| 2022-02-09 | TottenhamvSouthamptonPremier League · England | 2–3 | Premier League · England |
| 2022-02-09 | Chindia TargovistevFC ArgesSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-09 | WaregemvOostendePro League · Belgium | 0–0 | Pro League · Belgium |
| 2022-02-08 | GrimsbyvKings LynnNational League · England | 0–0 | National League · England |
| 2022-02-08 | NorthamptonvNewport CountyLeague Two · England | 1–0 | League Two · England |
| 2022-02-08 | PortsmouthvBurtonLeague One · England | 2–1 | League One · England |
| 2022-02-08 | AlloavFalkirkLeague One · Scotland | 0–3 | League One · Scotland |
| 2022-02-08 | Notts CountyvBarnetNational League · England | 6–1 | National League · England |
| 2022-02-08 | Fleetwood TownvMilton Keynes DonsLeague One · England | 1–1 | League One · England |
| 2022-02-08 | AccringtonvOxfordLeague One · England | 2–0 | League One · England |
| 2022-02-08 | ScunthorpevWalsallLeague Two · England | 1–0 | League Two · England |
| 2022-02-08 | SouthendvBromleyNational League · England | 2–0 | National League · England |
| 2022-02-08 | FulhamvMillwallChampionship · England | 3–0 | Championship · England |
| 2022-02-08 | StevenagevBradfordLeague Two · England | 0–1 | League Two · England |
| 2022-02-08 | FC VoluntarivFC Rapid BucurestiSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-02-08 | StockportvChesterfieldNational League · England | 2–2 | National League · England |
| 2022-02-08 | Forest GreenvRochdaleLeague Two · England | 2–1 | League Two · England |
| 2022-02-08 | Club LeonvCruz AzulLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-02-08 | Sepsi Sf. GheorghevGaz Metan MediasSuperliga · Romania | 2–0 | Superliga · Romania |
| 2022-02-08 | WealdstonevYeovilNational League · England | 2–1 | National League · England |
| 2022-02-08 | KarlsruhevSandhausen2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-02-08 | CoventryvBlackpoolChampionship · England | 1–1 | Championship · England |
| 2022-02-08 | LincolnvMorecambeLeague One · England | 2–1 | League One · England |
| 2022-02-08 | DerbyvHullChampionship · England | 3–1 | Championship · England |
| 2022-02-08 | AFC WimbledonvRotherhamLeague One · England | 0–1 | League One · England |
| 2022-02-08 | DoncastervIpswichLeague One · England | 0–1 | League One · England |
| 2022-02-08 | West HamvWatfordPremier League · England | 1–0 | Premier League · England |
| 2022-02-08 | SuttonvSalfordLeague Two · England | 0–0 | League Two · England |
| 2022-02-08 | HarrogatevCrawley TownLeague Two · England | 1–3 | League Two · England |
| 2022-02-08 | MansfieldvColchesterLeague Two · England | 2–1 | League Two · England |
| 2022-02-08 | CFR ClujvUTA AradSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-02-08 | BoltonvCharltonLeague One · England | 2–1 | League One · England |
| 2022-02-08 | TranmerevSwindonLeague Two · England | 3–0 | League Two · England |
| 2022-02-08 | Sheffield WedsvWiganLeague One · England | 1–0 | League One · England |
| 2022-02-08 | GillinghamvCambridgeLeague One · England | 1–0 | League One · England |
| 2022-02-08 | LutonvBarnsleyChampionship · England | 2–1 | Championship · England |
| 2022-02-08 | OldhamvBristol RvsLeague Two · England | 2–1 | League Two · England |
| 2022-02-08 | BurnleyvMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2022-02-08 | CarlislevPort ValeLeague Two · England | 1–3 | League Two · England |
| 2022-02-08 | CheltenhamvSunderlandLeague One · England | 2–1 | League One · England |
| 2022-02-08 | CrewevPlymouthLeague One · England | 1–4 | League One · England |
| 2022-02-08 | Queens ParkvDumbartonLeague One · Scotland | 2–1 | League One · Scotland |
| 2022-02-08 | HartlepoolvBarrowLeague Two · England | 3–1 | League Two · England |
| 2022-02-08 | ExetervLeyton OrientLeague Two · England | 1–0 | League Two · England |
| 2022-02-08 | NewcastlevEvertonPremier League · England | 3–1 | Premier League · England |
| 2022-02-08 | StokevSwanseaChampionship · England | 3–0 | Championship · England |
| 2022-02-08 | WycombevShrewsburyLeague One · England | 0–0 | League One · England |
| 2022-02-07 | Paris FCvAjaccioLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-02-07 | MoreirensevBelenensesPrimeira Liga · Portugal | 4–1 | Primeira Liga · Portugal |