| 2022-02-12 | LaziovBolognaSerie A · Italy | 3–0 | Serie A · Italy |
| 2022-02-11 | AltayvRizesporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2022-02-11 | SeraingvAntwerpPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-02-11 | Newells Old BoysvDefensa y JusticiaCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-11 | CracoviavLechia GdanskEkstraklasa · Poland | 2–0 | Ekstraklasa · Poland |
| 2022-02-11 | Hansa RostockvWerder Bremen2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2022-02-11 | LecznavSlask WroclawEkstraklasa · Poland | 1–1 | Ekstraklasa · Poland |
| 2022-02-11 | RB LeipzigvFC KolnBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2022-02-11 | Erzgebirge AuevHolstein Kiel2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2022-02-11 | Edinburgh CityvStirlingLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2022-02-11 | Velez SarsfieldvAldosiviCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-11 | SevillavElcheLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-02-11 | HeraclesvUtrechtEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-02-11 | PortovSp LisbonPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2022-02-11 | SK RapidvSalzburgBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2022-02-11 | Paris SGvRennesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-02-11 | Arsenal SarandivRosario CentralCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-11 | Godoy CruzvTigreCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-11 | FC Rapid BucurestivSepsi Sf. GheorgheSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-11 | LeganesvZaragozaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-02-11 | Central CordobavBarracas CentralCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-10 | Sarmiento JuninvAtl. TucumanCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-10 | WolvesvArsenalPremier League · England | 0–1 | Premier League · England |
| 2022-02-10 | JuarezvGuadalajara ChivasLiga MX · Mexico | 1–3 | Liga MX · Mexico |
| 2022-02-10 | AtromitosvLamiaSuper League · Greece | 3–1 | Super League · Greece |
| 2022-02-10 | PatronatovArgentinos JrsCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-10 | LiverpoolvLeicesterPremier League · England | 2–0 | Premier League · England |
| 2022-02-10 | Din. BucurestivUniv. CraiovaSuperliga · Romania | 1–6 | Superliga · Romania |
| 2022-02-10 | U Craiova 1948vFC BotosaniSuperliga · Romania | 3–2 | Superliga · Romania |
| 2022-02-09 | KilmarnockvAyrChampionship · Scotland | 1–2 | Championship · Scotland |
| 2022-02-09 | Academica ClincenivFCSBSuperliga · Romania | 0–3 | Superliga · Romania |
| 2022-02-09 | ArbroathvHamiltonChampionship · Scotland | 2–2 | Championship · Scotland |
| 2022-02-09 | NorwichvCrystal PalacePremier League · England | 1–1 | Premier League · England |
| 2022-02-09 | Man CityvBrentfordPremier League · England | 2–0 | Premier League · England |
| 2022-02-09 | CardiffvPeterboroChampionship · England | 4–0 | Championship · England |
| 2022-02-09 | Bristol CityvReadingChampionship · England | 2–1 | Championship · England |
| 2022-02-09 | QPRvMiddlesbroughChampionship · England | 2–2 | Championship · England |
| 2022-02-09 | Oud-Heverlee LeuvenvGenkPro League · Belgium | 2–1 | Pro League · Belgium |
| 2022-02-09 | Sheffield UnitedvWest BromChampionship · England | 2–0 | Championship · England |
| 2022-02-09 | MiovenivFarul ConstantaSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-09 | Ross CountyvLivingstonPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-02-09 | Aston VillavLeedsPremier League · England | 3–3 | Premier League · England |
| 2022-02-09 | BlackburnvNott'm ForestChampionship · England | 0–2 | Championship · England |
| 2022-02-09 | Dundee UnitedvMotherwellPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2022-02-09 | St MirrenvSt JohnstonePremiership · Scotland | 2–1 | Premiership · Scotland |
| 2022-02-09 | BournemouthvBirminghamChampionship · England | 3–1 | Championship · England |
| 2022-02-09 | Inverness CvPartickChampionship · Scotland | 3–3 | Championship · Scotland |
| 2022-02-09 | HeartsvDundeePremiership · Scotland | 1–2 | Premiership · Scotland |
| 2022-02-09 | AberdeenvCelticPremiership · Scotland | 2–3 | Premiership · Scotland |
| 2022-02-09 | RangersvHibernianPremiership · Scotland | 2–0 | Premiership · Scotland |