| 2021-02-27 | SwanseavBristol CityChampionship · England | 1–3 | Championship · England |
| 2021-02-27 | KhimkivUfaPremier League · Russia | 2–1 | Premier League · Russia |
| 2021-02-27 | Kings LynnvWeymouthNational League · England | 2–2 | National League · England |
| 2021-02-27 | PeterborovWiganLeague One · England | 2–1 | League One · England |
| 2021-02-27 | SochauxvGuingampLigue 2 · France | 0–0 | Ligue 2 · France |
| 2021-02-27 | YeovilvDag and RedNational League · England | 1–0 | National League · England |
| 2021-02-27 | WalsallvBradfordLeague Two · England | 1–2 | League Two · England |
| 2021-02-27 | Sanfrecce HiroshimavVegalta SendaiJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-02-27 | OostendevMechelenPro League · Belgium | 2–0 | Pro League · Belgium |
| 2021-02-27 | CremonesevFrosinoneSerie B · Italy | 4–0 | Serie B · Italy |
| 2021-02-27 | ApollonvOFI CreteSuper League · Greece | 2–1 | Super League · Greece |
| 2021-02-27 | Academica ClincenivAstraSuperliga · Romania | 1–1 | Superliga · Romania |
| 2021-02-27 | SevillavBarcelonaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-02-27 | Boreham WoodvSolihullNational League · England | 2–2 | National League · England |
| 2021-02-27 | Den HaagvWaalwijkEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-02-27 | IpswichvDoncasterLeague One · England | 2–1 | League One · England |
| 2021-02-27 | PescaravLecceSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-27 | PisavVicenzaSerie B · Italy | 2–2 | Serie B · Italy |
| 2021-02-27 | ScunthorpevCheltenhamLeague Two · England | 0–2 | League Two · England |
| 2021-02-27 | SochivArsenal TulaPremier League · Russia | 4–0 | Premier League · Russia |
| 2021-02-27 | WrexhamvWealdstoneNational League · England | 4–1 | National League · England |
| 2021-02-27 | Urawa RedsvFC TokyoJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-02-27 | DijonvParis SGLigue 1 · France | 0–4 | Ligue 1 · France |
| 2021-02-27 | BlackburnvCoventryChampionship · England | 1–1 | Championship · England |
| 2021-02-27 | PordenonevAscoliSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-27 | SwindonvNorthamptonLeague One · England | 2–1 | League One · England |
| 2021-02-27 | IndependientevGimnasia L.P.Copa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2021-02-27 | MortonvDundeeChampionship · Scotland | 2–2 | Championship · Scotland |
| 2021-02-27 | Queen of SthvDunfermlineChampionship · Scotland | 1–0 | Championship · Scotland |
| 2021-02-27 | Shonan BellmarevSagan TosuJ1 League · Japan | 0–1 | J1 League · Japan |
| 2021-02-27 | DortmundvBielefeldBundesliga · Germany | 3–0 | Bundesliga · Germany |
| 2021-02-27 | ClermontvValenciennesLigue 2 · France | 4–0 | Ligue 2 · France |
| 2021-02-27 | DunkerquevChamblyLigue 2 · France | 1–1 | Ligue 2 · France |
| 2021-02-27 | West BromvBrightonPremier League · England | 1–0 | Premier League · England |
| 2021-02-27 | BolognavLazioSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-02-27 | LutonvSheffield WedsChampionship · England | 3–2 | Championship · England |
| 2021-02-27 | CaenvParis FCLigue 2 · France | 0–2 | Ligue 2 · France |
| 2021-02-27 | RizesporvSivassporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2021-02-27 | Cerezo OsakavKashiwa ReysolJ1 League · Japan | 2–0 | J1 League · Japan |
| 2021-02-27 | GetafevValenciaLa Liga · Spain | 3–0 | La Liga · Spain |
| 2021-02-27 | CelticvAberdeenPremiership · Scotland | 1–0 | Premiership · Scotland |
| 2021-02-27 | JagielloniavPiast GliwiceEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-02-27 | HibernianvMotherwellPremiership · Scotland | 0–2 | Premiership · Scotland |
| 2021-02-27 | HeraclesvTwenteEredivisie · Netherlands | 2–2 | Eredivisie · Netherlands |
| 2021-02-27 | ZenitvFK RostovPremier League · Russia | 2–2 | Premier League · Russia |
| 2021-02-27 | BromleyvAltrinchamNational League · England | 3–1 | National League · England |
| 2021-02-27 | VeronavJuventusSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-02-27 | BordeauxvMetzLigue 1 · France | 1–2 | Ligue 1 · France |
| 2021-02-27 | KilmarnockvDundee UnitedPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-02-27 | UtrechtvFC EmmenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |