| 2022-02-12 | HullvFulhamChampionship · England | 0–1 | Championship · England |
| 2022-02-12 | VicenzavCosenzaSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-02-12 | GiresunsporvFenerbahceSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-02-12 | Paris FCvQuevilly RouenLigue 2 · France | 3–0 | Ligue 2 · France |
| 2022-02-12 | ElginvStranraerLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2022-02-12 | LyonvNiceLigue 1 · France | 2–0 | Ligue 1 · France |
| 2022-02-12 | Newport CountyvOldhamLeague Two · England | 3–3 | League Two · England |
| 2022-02-12 | PisavTernanaSerie B · Italy | 0–0 | Serie B · Italy |
| 2022-02-12 | St. GallenvServetteSuper League · Switzerland | 5–1 | Super League · Switzerland |
| 2022-02-12 | Gaz Metan MediasvCFR ClujSuperliga · Romania | 1–2 | Superliga · Romania |
| 2022-02-12 | BirminghamvLutonChampionship · England | 3–0 | Championship · England |
| 2022-02-12 | AmiensvNiortLigue 2 · France | 3–1 | Ligue 2 · France |
| 2022-02-12 | KilmarnockvDunfermlineChampionship · Scotland | 2–1 | Championship · Scotland |
| 2022-02-12 | Crawley TownvHartlepoolLeague Two · England | 0–1 | League Two · England |
| 2022-02-12 | BarnetvWealdstoneNational League · England | 1–3 | National League · England |
| 2022-02-12 | MillwallvCardiffChampionship · England | 2–1 | Championship · England |
| 2022-02-12 | AccringtonvCreweLeague One · England | 4–1 | League One · England |
| 2022-02-12 | SwindonvScunthorpeLeague Two · England | 3–0 | League Two · England |
| 2022-02-12 | WokingvSouthendNational League · England | 2–3 | National League · England |
| 2022-02-12 | TorinovVeneziaSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-02-12 | Airdrie UtdvMontroseLeague One · Scotland | 4–1 | League One · Scotland |
| 2022-02-12 | OxfordvBoltonLeague One · England | 2–3 | League One · England |
| 2022-02-12 | SuttonvForest GreenLeague Two · England | 1–1 | League Two · England |
| 2022-02-12 | AuxerrevNancyLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-12 | MiddlesbroughvDerbyChampionship · England | 4–1 | Championship · England |
| 2022-02-12 | Union de Santa FevRiver PlateCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-12 | ValenciennesvToulouseLigue 2 · France | 1–3 | Ligue 2 · France |
| 2022-02-12 | VillarrealvReal MadridLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-02-12 | BurtonvCambridgeLeague One · England | 2–2 | League One · England |
| 2022-02-12 | GrenoblevSochauxLigue 2 · France | 1–3 | Ligue 2 · France |
| 2022-02-12 | WislavStal MielecEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-02-12 | GalatasarayvKayserisporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-02-12 | ValladolidvGironaLa Liga 2 · Spain | 2–2 | La Liga 2 · Spain |
| 2022-02-12 | M'gladbachvAugsburgBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-02-12 | PlymouthvShrewsburyLeague One · England | 1–0 | League One · England |
| 2022-02-12 | BlackpoolvBournemouthChampionship · England | 1–2 | Championship · England |
| 2022-02-12 | GrimsbyvAldershotNational League · England | 3–1 | National League · England |
| 2022-02-12 | ReadingvCoventryChampionship · England | 2–3 | Championship · England |
| 2022-02-12 | ApollonvPanetolikosSuper League · Greece | 0–0 | Super League · Greece |
| 2022-02-12 | BradfordvExeterLeague Two · England | 0–1 | League Two · England |
| 2022-02-12 | Lech PoznanvTermalica B-B.Ekstraklasa · Poland | 5–0 | Ekstraklasa · Poland |
| 2022-02-12 | Ein FrankfurtvWolfsburgBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2022-02-12 | HuracanvLanusCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-12 | Leyton OrientvSalfordLeague Two · England | 0–2 | League Two · England |
| 2022-02-12 | FreiburgvMainzBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-02-12 | Radomiak RadomvRakowEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-02-12 | RegginavCrotoneSerie B · Italy | 1–0 | Serie B · Italy |
| 2022-02-12 | Wolfsberger ACvRiedBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2022-02-12 | PueblavAtlasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2022-02-12 | Guadalajara ChivasvTigres UANLLiga MX · Mexico | 1–3 | Liga MX · Mexico |