| 2016-02-07 | RomavSampdoriaSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-02-07 | UtrechtvPSV EindhovenEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2016-02-07 | ChelseavMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2016-02-07 | Club BruggevGentPro League · Belgium | 1–0 | Pro League · Belgium |
| 2016-02-07 | GraafschapvNijmegenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2016-02-07 | AtalantavEmpoliSerie A · Italy | 0–0 | Serie A · Italy |
| 2016-02-07 | BetisvValenciaLa Liga · Spain | 1–0 | La Liga · Spain |
| 2016-02-07 | StandardvSt TruidenPro League · Belgium | 1–2 | Pro League · Belgium |
| 2016-02-07 | MallorcavAth Bilbao BLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2016-02-07 | LillevRennesLigue 1 · France | 1–1 | Ligue 1 · France |
| 2016-02-07 | RizesporvEskisehirsporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2016-02-07 | LevantevBarcelonaLa Liga · Spain | 0–2 | La Liga · Spain |
| 2016-02-07 | CeltavSevillaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2016-02-07 | OlympiakosvPAOKSuper League · Greece | 1–0 | Super League · Greece |
| 2016-02-07 | BournemouthvArsenalPremier League · England | 0–2 | Premier League · England |
| 2016-02-07 | Pacos FerreiravBoavistaPrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2016-02-07 | Port ValevCoventryLeague One · England | 1–1 | League One · England |
| 2016-02-07 | MilanvUdineseSerie A · Italy | 1–1 | Serie A · Italy |
| 2016-02-07 | BarnsleyvBuryLeague One · England | 3–0 | League One · England |
| 2016-02-07 | IndependientevBelgranoLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2016-02-07 | Fleetwood TownvShrewsburyLeague One · England | 0–0 | League One · England |
| 2016-02-07 | VeronavInterSerie A · Italy | 3–3 | Serie A · Italy |
| 2016-02-07 | TemperleyvBoca JuniorsLiga Profesional · Argentina | 0–0 | Liga Profesional · Argentina |
| 2016-02-07 | RB LeipzigvBraunschweig2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2016-02-07 | KarlsruhevFrankfurt FSV2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2016-02-07 | AjaxvFeyenoordEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2016-02-07 | HoffenheimvDarmstadtBundesliga · Germany | 0–2 | Bundesliga · Germany |
| 2016-02-07 | BaselvLuzernSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2016-02-07 | Greuther FurthvSt Pauli2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2016-02-07 | SassuolovPalermoSerie A · Italy | 2–2 | Serie A · Italy |
| 2016-02-07 | VeriavKallonisSuper League · Greece | 2–0 | Super League · Greece |
| 2016-02-07 | UNAM PumasvPachucaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2016-02-07 | BesiktasvGaziantepsporSüper Lig · Turkey | 4–0 | Süper Lig · Turkey |
| 2016-02-07 | AdmiravSalzburgBundesliga · Austria | 1–2 | Bundesliga · Austria |
| 2016-02-07 | Akhisar BelediyesporvTrabzonsporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2016-02-07 | Colon Santa FEvArsenal SarandiLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2016-02-07 | PortovAroucaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2016-02-07 | GranadavReal MadridLa Liga · Spain | 1–2 | La Liga · Spain |
| 2016-02-07 | AlavesvLlagosteraLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2016-02-07 | PueblavAtlasLiga MX · Mexico | 4–1 | Liga MX · Mexico |
| 2016-02-07 | Club LeonvMonarcasLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2016-02-07 | GironavGimnasticLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2016-02-07 | Defensa y JusticiavUnion de Santa FeLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2016-02-07 | AtromitosvAEKSuper League · Greece | 1–0 | Super League · Greece |
| 2016-02-07 | Uniao MadeiravMoreirensePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2016-02-07 | IraklisvGianninaSuper League · Greece | 1–0 | Super League · Greece |
| 2016-02-07 | GroningenvCambuurEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2016-02-07 | ZurichvSionSuper League · Switzerland | 0–1 | Super League · Switzerland |
| 2016-02-07 | FrosinonevJuventusSerie A · Italy | 0–2 | Serie A · Italy |
| 2016-02-07 | HamburgvFC KolnBundesliga · Germany | 1–1 | Bundesliga · Germany |