| 2021-11-28 | MontpelliervLyonLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-11-28 | LivingstonvRangersPremiership · Scotland | 1–3 | Premiership · Scotland |
| 2021-11-28 | InternacionalvSantosBrasileirão · Brazil | 1–1 | Brasileirão · Brazil |
| 2021-11-28 | Sao PaulovSport RecifeBrasileirão · Brazil | 2–0 | Brasileirão · Brazil |
| 2021-11-28 | HeerenveenvPSV EindhovenEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-11-28 | DegerforsvNorrkopingAllsvenskan · Sweden | 4–1 | Allsvenskan · Sweden |
| 2021-11-28 | ZurichvYoung BoysSwiss Super League · Switzerland | 1–0 | Swiss Super League · Switzerland |
| 2021-11-28 | Rosario CentralvRiver PlateLiga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2021-11-28 | MilanvSassuoloSerie A · Italy | 1–3 | Serie A · Italy |
| 2021-11-28 | Estudiantes L.P.vVelez SarsfieldLiga Profesional · Argentina | 1–0 | Liga Profesional · Argentina |
| 2021-11-28 | Sporting Kansas CityvReal Salt LakeMLS · United States | 1–2 | MLS · United States |
| 2021-11-28 | St EtiennevParis SGLigue 1 · France | 1–3 | Ligue 1 · France |
| 2021-11-28 | Ein FrankfurtvUnion BerlinBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2021-11-28 | Yeni MalatyasporvGalatasaraySüper Lig · Türkiye | 0–0 | Süper Lig · Türkiye |
| 2021-11-28 | AmorebietavZaragozaLaLiga 2 · Spain | 1–1 | LaLiga 2 · Spain |
| 2021-11-28 | TenerifevSociedad BLaLiga 2 · Spain | 2–0 | LaLiga 2 · Spain |
| 2021-11-28 | VitessevAZ AlkmaarEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-11-28 | LegiavJagielloniaEkstraklasa · Poland | 1–0 | Ekstraklasa · Poland |
| 2021-11-28 | Real MadridvSevillaLaLiga · Spain | 2–1 | LaLiga · Spain |
| 2021-11-28 | HaugesundvSandefjordEliteserien · Norway | 1–2 | Eliteserien · Norway |
| 2021-11-28 | RiedvSK RapidAustrian Bundesliga · Austria | 2–2 | Austrian Bundesliga · Austria |
| 2021-11-28 | FC BotosanivFC VoluntariLiga I · Romania | 1–1 | Liga I · Romania |
| 2021-11-28 | CSKA MoscowvZenitRussian Premier League · Russia | 0–2 | Russian Premier League · Russia |
| 2021-11-28 | MarseillevTroyesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-11-28 | RosenborgvBodo/GlimtEliteserien · Norway | 0–0 | Eliteserien · Norway |
| 2021-11-28 | LausannevServetteSwiss Super League · Switzerland | 0–3 | Swiss Super League · Switzerland |
| 2021-11-28 | TwentevFeyenoordEredivisie · Netherlands | 0–0 | Eredivisie · Netherlands |
| 2021-11-28 | HartbergvLASKAustrian Bundesliga · Austria | 2–1 | Austrian Bundesliga · Austria |
| 2021-11-28 | IbizavPonferradinaLaLiga 2 · Spain | 0–1 | LaLiga 2 · Spain |
| 2021-11-28 | ComovParmaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-11-28 | PaderbornvHansa Rostock2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-11-28 | Defensa y JusticiavColon Santa FELiga Profesional · Argentina | 1–1 | Liga Profesional · Argentina |
| 2021-11-28 | Sparta RotterdamvAjaxEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2021-11-28 | AalborgvFC CopenhagenDanish Superliga · Denmark | 1–3 | Danish Superliga · Denmark |
| 2021-11-28 | UtrechtvHeraclesEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2021-11-28 | CadizvAth MadridLaLiga · Spain | 1–4 | LaLiga · Spain |
| 2021-11-28 | DjurgardenvVarbergAllsvenskan · Sweden | 2–3 | Allsvenskan · Sweden |
| 2021-11-28 | OdensevNordsjaellandDanish Superliga · Denmark | 2–0 | Danish Superliga · Denmark |
| 2021-11-28 | Pari NNvKrylya SovetovRussian Premier League · Russia | 0–0 | Russian Premier League · Russia |
| 2021-11-28 | Sp LisbonvTondelaPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2021-11-28 | PAOKvArisSuper League Greece · Greece | 0–1 | Super League Greece · Greece |
| 2021-11-28 | CorinthiansvAthletico-PRBrasileirão · Brazil | 1–0 | Brasileirão · Brazil |
| 2021-11-28 | LeganesvLas PalmasLaLiga 2 · Spain | 4–1 | LaLiga 2 · Spain |
| 2021-11-28 | CelticvAberdeenPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2021-11-28 | MjondalenvSarpsborg 08Eliteserien · Norway | 1–3 | Eliteserien · Norway |
| 2021-11-28 | KaragumrukvTrabzonsporSüper Lig · Türkiye | 0–2 | Süper Lig · Türkiye |
| 2021-11-28 | GaziantepvKonyasporSüper Lig · Türkiye | 3–2 | Süper Lig · Türkiye |
| 2021-11-28 | ChelseavMan UnitedPremier League · England | 1–1 | Premier League · England |
| 2021-11-28 | NurnbergvSt Pauli2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2021-11-28 | MaritimovPacos FerreiraPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |