| 2010-11-13 | TorquayvBarnetLeague Two · England | 1–1 | League Two · England |
| 2010-11-13 | LeedsvBristol CityChampionship · England | 3–1 | Championship · England |
| 2010-11-13 | FC KolnvM'gladbachBundesliga · Germany | 0–4 | Bundesliga · Germany |
| 2010-11-13 | BurnleyvWatfordChampionship · England | 3–2 | Championship · England |
| 2010-11-13 | Man CityvBirminghamPremier League · England | 0–0 | Premier League · England |
| 2010-11-13 | Bristol RvsvLeyton OrientLeague One · England | 0–3 | League One · England |
| 2010-11-13 | DarlingtonvCrawley TownNational League · England | 1–1 | National League · England |
| 2010-11-13 | St PaulivLeverkusenBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2010-11-13 | Eastbourne BoroughvNewport CountyNational League · England | 0–0 | National League · England |
| 2010-11-13 | WiganvWest BromPremier League · England | 1–0 | Premier League · England |
| 2010-11-13 | Frankfurt FSVvUnion Berlin2. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2010-11-13 | WycombevBradfordLeague Two · England | 1–0 | League Two · England |
| 2010-11-13 | Kettering TownvCambridgeNational League · England | 2–2 | National League · England |
| 2010-11-13 | CarlislevSouthamptonLeague One · England | 3–2 | League One · England |
| 2010-11-13 | LeicestervDerbyChampionship · England | 2–0 | Championship · England |
| 2010-11-13 | Queen of SthvCowdenbeathChampionship · Scotland | 3–0 | Championship · Scotland |
| 2010-11-13 | SwindonvColchesterLeague One · England | 2–1 | League One · England |
| 2010-11-13 | BrestvSochauxLigue 1 · France | 1–1 | Ligue 1 · France |
| 2010-11-13 | West HamvBlackpoolPremier League · England | 0–0 | Premier League · England |
| 2010-11-13 | PSV EindhovenvExcelsiorEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2010-11-13 | DumbartonvAyrLeague One · Scotland | 3–2 | League One · Scotland |
| 2010-11-13 | RegginavTorinoSerie B · Italy | 1–1 | Serie B · Italy |
| 2010-11-13 | CrotonevLivornoSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-11-13 | WolvesvBoltonPremier League · England | 2–3 | Premier League · England |
| 2010-11-13 | RotherhamvOxfordLeague Two · England | 2–1 | League Two · England |
| 2010-11-13 | GimnasticvElcheLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2010-11-13 | Fleetwood TownvRushden & DNational League · England | 1–1 | National League · England |
| 2010-11-13 | BetisvXerezLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2010-11-13 | KerkyravXanthiSuper League · Greece | 1–1 | Super League · Greece |
| 2010-11-13 | Airdrie UtdvLivingstonLeague One · Scotland | 0–1 | League One · Scotland |
| 2010-11-13 | TranmerevPlymouthLeague One · England | 1–0 | League One · England |
| 2010-11-13 | FiorentinavCesenaSerie A · Italy | 1–0 | Serie A · Italy |
| 2010-11-13 | CaenvLilleLigue 1 · France | 2–5 | Ligue 1 · France |
| 2010-11-13 | EskisehirsporvAntalyasporSüper Lig · Turkey | 0–0 | Süper Lig · Turkey |
| 2010-11-13 | HerefordvCheltenhamLeague Two · England | 1–1 | League Two · England |
| 2010-11-13 | Queens ParkvAlbion RvsLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2010-11-13 | BrentfordvMilton Keynes DonsLeague One · England | 0–2 | League One · England |
| 2010-11-13 | TamworthvGatesheadNational League · England | 1–1 | National League · England |
| 2010-11-13 | PeterborovCharltonLeague One · England | 1–5 | League One · England |
| 2010-11-13 | HartlepoolvBrightonLeague One · England | 3–1 | League One · England |
| 2010-11-13 | StranraervAnnan AthleticLeague Two · Scotland | 2–2 | League Two · Scotland |
| 2010-11-13 | MillwallvSheffield UnitedChampionship · England | 0–1 | Championship · England |
| 2010-11-13 | NewcastlevFulhamPremier League · England | 0–0 | Premier League · England |
| 2010-11-13 | WolfsburgvSchalke 04Bundesliga · Germany | 2–2 | Bundesliga · Germany |
| 2010-11-13 | YeovilvDag and RedLeague One · England | 1–3 | League One · England |
| 2010-11-13 | AlbinoleffevCittadellaSerie B · Italy | 1–3 | Serie B · Italy |
| 2010-11-13 | Nott'm ForestvQPRChampionship · England | 0–0 | Championship · England |
| 2010-11-13 | PanathinaikosvLarisaSuper League · Greece | 1–1 | Super League · Greece |
| 2010-11-13 | VaresevSassuoloSerie B · Italy | 2–1 | Serie B · Italy |
| 2010-11-13 | JuventusvRomaSerie A · Italy | 1–1 | Serie A · Italy |