| 2022-02-12 | Dover AthleticvTorquayNational League · England | 1–3 | National League · England |
| 2022-02-12 | PaderbornvDresden2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-02-12 | EupenvGentPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-02-12 | DijonvPau FCLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-02-12 | Asteras TripolisvIonikosSuper League · Greece | 2–3 | Super League · Greece |
| 2022-02-12 | ParmavPordenoneSerie B · Italy | 4–1 | Serie B · Italy |
| 2022-02-12 | EastleighvYeovilNational League · England | 0–0 | National League · England |
| 2022-02-12 | EstorilvTondelaPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-02-12 | VallecanovOsasunaLa Liga · Spain | 0–3 | La Liga · Spain |
| 2022-02-12 | Oud-Heverlee LeuvenvCercle BruggePro League · Belgium | 3–2 | Pro League · Belgium |
| 2022-02-12 | MonzavSpalSerie B · Italy | 4–0 | Serie B · Italy |
| 2022-02-12 | Port ValevNorthamptonLeague Two · England | 0–0 | League Two · England |
| 2022-02-12 | Milton Keynes DonsvIpswichLeague One · England | 0–0 | League One · England |
| 2022-02-12 | EvertonvLeedsPremier League · England | 3–0 | Premier League · England |
| 2022-02-12 | WaregemvAnderlechtPro League · Belgium | 1–2 | Pro League · Belgium |
| 2022-02-12 | WalsallvTranmereLeague Two · England | 1–0 | League Two · England |
| 2022-02-12 | PortimonensevBoavistaPrimeira Liga · Portugal | 1–1 | Primeira Liga · Portugal |
| 2022-02-12 | BenficavSanta ClaraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-02-12 | WeymouthvChesterfieldNational League · England | 1–1 | National League · England |
| 2022-02-12 | MortonvQueen of SthChampionship · Scotland | 2–1 | Championship · Scotland |
| 2022-02-12 | Farul ConstantavFC VoluntariSuperliga · Romania | 3–0 | Superliga · Romania |
| 2022-02-12 | NorwichvMan CityPremier League · England | 0–4 | Premier League · England |
| 2022-02-12 | LincolnvWycombeLeague One · England | 1–1 | League One · England |
| 2022-02-12 | Bristol RvsvMansfieldLeague Two · England | 0–0 | League Two · England |
| 2022-02-12 | HamburgvHeidenheim2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-02-12 | GroningenvFor SittardEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-02-12 | TirolvSturm GrazBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2022-02-12 | KarlsruhevNurnberg2. Bundesliga · Germany | 4–1 | 2. Bundesliga · Germany |
| 2022-02-12 | CaenvNimesLigue 2 · France | 4–0 | Ligue 2 · France |
| 2022-02-12 | HuddersfieldvSheffield UnitedChampionship · England | 0–0 | Championship · England |
| 2022-02-12 | VitessevPSV EindhovenEredivisie · Netherlands | 0–5 | Eredivisie · Netherlands |
| 2022-02-12 | RegensburgvSt Pauli2. Bundesliga · Germany | 2–3 | 2. Bundesliga · Germany |
| 2022-02-12 | CheltenhamvFleetwood TownLeague One · England | 2–0 | League One · England |
| 2022-02-12 | MalagavAlmeriaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2022-02-12 | BarnsleyvQPRChampionship · England | 1–0 | Championship · England |
| 2022-02-12 | WiganvCharltonLeague One · England | 2–1 | League One · England |
| 2022-02-12 | BrentfordvCrystal PalacePremier League · England | 0–0 | Premier League · England |
| 2022-02-12 | BochumvBayern MunichBundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2022-02-12 | Man UnitedvSouthamptonPremier League · England | 1–1 | Premier League · England |
| 2022-02-12 | WatfordvBrightonPremier League · England | 0–2 | Premier League · England |
| 2022-02-12 | CittadellavCremoneseSerie B · Italy | 0–2 | Serie B · Italy |
| 2022-02-12 | Mazatlan FCvClub TijuanaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-02-12 | BarrowvStevenageLeague Two · England | 0–0 | League Two · England |
| 2022-02-12 | AltachvAustria ViennaBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2022-02-12 | CadizvCeltaLa Liga · Spain | 0–0 | La Liga · Spain |
| 2022-02-12 | ColchestervCarlisleLeague Two · England | 2–2 | League Two · England |
| 2022-02-12 | DunkerquevRodezLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-02-12 | Sp BragavPacos FerreiraPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-02-12 | AjacciovGuingampLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-02-12 | Cove RangersvQueens ParkLeague One · Scotland | 0–0 | League One · Scotland |