| 2021-02-28 | FC CopenhagenvAarhusSuperliga · Denmark | 3–3 | Superliga · Denmark |
| 2021-02-28 | OdensevRanders FCSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-02-28 | LeicestervArsenalPremier League · England | 1–3 | Premier League · England |
| 2021-02-28 | SionvVaduzSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2021-02-28 | GranadavElcheLa Liga · Spain | 2–1 | La Liga · Spain |
| 2021-02-28 | ArisvAtromitosSuper League · Greece | 3–0 | Super League · Greece |
| 2021-02-28 | Beerschot VAvMouscronPro League · Belgium | 2–2 | Pro League · Belgium |
| 2021-02-28 | Club LeonvCruz AzulLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-02-28 | MonterreyvClub TijuanaLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-02-28 | FC HermannstadtvSepsi Sf. GheorgheSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-02-28 | StandardvAnderlechtPro League · Belgium | 1–3 | Pro League · Belgium |
| 2021-02-27 | PortsmouthvGillinghamLeague One · England | 1–1 | League One · England |
| 2021-02-27 | EibarvHuescaLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-02-27 | BoltonvBarrowLeague Two · England | 1–0 | League Two · England |
| 2021-02-27 | BournemouthvWatfordChampionship · England | 1–0 | Championship · England |
| 2021-02-27 | Crawley TownvExeterLeague Two · England | 2–0 | League Two · England |
| 2021-02-27 | AlmeriavLugoLa Liga 2 · Spain | 4–1 | La Liga 2 · Spain |
| 2021-02-27 | Pau FCvLe HavreLigue 2 · France | 2–0 | Ligue 2 · France |
| 2021-02-27 | BirminghamvQPRChampionship · England | 2–1 | Championship · England |
| 2021-02-27 | Newport CountyvStevenageLeague Two · England | 0–0 | League Two · England |
| 2021-02-27 | Leyton OrientvTranmereLeague Two · England | 1–3 | League Two · England |
| 2021-02-27 | Gaz Metan MediasvUTA AradSuperliga · Romania | 1–2 | Superliga · Romania |
| 2021-02-27 | Port ValevCambridgeLeague Two · England | 0–1 | League Two · England |
| 2021-02-27 | SouthendvSalfordLeague Two · England | 0–0 | League Two · England |
| 2021-02-27 | AlavesvOsasunaLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-02-27 | HartlepoolvBarnetNational League · England | 1–0 | National League · England |
| 2021-02-27 | TroyesvAjaccioLigue 2 · France | 1–0 | Ligue 2 · France |
| 2021-02-27 | Argentinos JrsvVelez SarsfieldCopa De La Liga Profesional · Argentina | 0–2 | Copa De La Liga Profesional · Argentina |
| 2021-02-27 | PortovSp LisbonPrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-02-27 | Talleres CordobavNewells Old BoysCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2021-02-27 | Milton Keynes DonsvOxfordLeague One · England | 1–1 | League One · England |
| 2021-02-27 | StuttgartvSchalke 04Bundesliga · Germany | 5–1 | Bundesliga · Germany |
| 2021-02-27 | ToulousevAmiensLigue 2 · France | 3–0 | Ligue 2 · France |
| 2021-02-27 | Gornik Z.vLegiaEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2021-02-27 | PueblavNecaxaLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-02-27 | Virtus EntellavBresciaSerie B · Italy | 1–1 | Serie B · Italy |
| 2021-02-27 | Bristol RvsvShrewsburyLeague One · England | 2–1 | League One · England |
| 2021-02-27 | CharltonvBlackpoolLeague One · England | 0–3 | League One · England |
| 2021-02-27 | Man CityvWest HamPremier League · England | 2–1 | Premier League · England |
| 2021-02-27 | AFC WimbledonvHullLeague One · England | 0–3 | League One · England |
| 2021-02-27 | ChateaurouxvNancyLigue 2 · France | 1–4 | Ligue 2 · France |
| 2021-02-27 | FamalicaovFarensePrimeira Liga · Portugal | 0–0 | Primeira Liga · Portugal |
| 2021-02-27 | SK RapidvRiedBundesliga · Austria | 1–0 | Bundesliga · Austria |
| 2021-02-27 | BochumvWurzburger Kickers2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-02-27 | Stal MielecvLechia GdanskEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-02-27 | Asteras TripolisvPAOKSuper League · Greece | 2–1 | Super League · Greece |
| 2021-02-27 | Holstein KielvErzgebirge Aue2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2021-02-27 | Oita TrinitavTokushimaJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-02-27 | CosenzavChievoSerie B · Italy | 1–0 | Serie B · Italy |
| 2021-02-27 | CrewevSunderlandLeague One · England | 2–2 | League One · England |