| 2022-02-13 | HoffenheimvBielefeldBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2022-02-13 | SassuolovRomaSerie A · Italy | 2–2 | Serie A · Italy |
| 2022-02-13 | Pogon SzczecinvZaglebieEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2022-02-13 | EibarvFuenlabradaLa Liga 2 · Spain | 0–0 | La Liga 2 · Spain |
| 2022-02-13 | SociedadvGranadaLa Liga · Spain | 2–0 | La Liga · Spain |
| 2022-02-13 | BrestvTroyesLigue 1 · France | 5–1 | Ligue 1 · France |
| 2022-02-13 | Santos LagunavClub AmericaLiga MX · Mexico | 2–3 | Liga MX · Mexico |
| 2022-02-13 | PAOKvAtromitosSuper League · Greece | 1–0 | Super League · Greece |
| 2022-02-13 | AscolivComoSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-13 | SivassporvYeni MalatyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-02-13 | AjaxvTwenteEredivisie · Netherlands | 5–0 | Eredivisie · Netherlands |
| 2022-02-13 | OlympiakosvAEKSuper League · Greece | 1–0 | Super League · Greece |
| 2022-02-13 | LensvBordeauxLigue 1 · France | 3–2 | Ligue 1 · France |
| 2022-02-13 | EmpolivCagliariSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-13 | WaalwijkvFeyenoordEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2022-02-13 | Estudiantes L.P.vIndependienteCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-13 | LevantevBetisLa Liga · Spain | 2–4 | La Liga · Spain |
| 2022-02-13 | Fortuna DusseldorfvSchalke 042. Bundesliga · Germany | 2–1 | 2. Bundesliga · Germany |
| 2022-02-13 | PlatensevTalleres CordobaCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-13 | MetzvMarseilleLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-02-13 | HartbergvAdmiraBundesliga · Austria | 1–1 | Bundesliga · Austria |
| 2022-02-13 | Wisla PlockvPiast GliwiceEkstraklasa · Poland | 0–2 | Ekstraklasa · Poland |
| 2022-02-13 | EspanolvBarcelonaLa Liga · Spain | 2–2 | La Liga · Spain |
| 2022-02-13 | Go Ahead EaglesvAZ AlkmaarEredivisie · Netherlands | 1–4 | Eredivisie · Netherlands |
| 2022-02-13 | UNAM PumasvClub LeonLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-02-13 | UTA AradvDin. BucurestiSuperliga · Romania | 0–0 | Superliga · Romania |
| 2022-02-13 | OviedovHuescaLa Liga 2 · Spain | 3–3 | La Liga 2 · Spain |
| 2022-02-12 | Greuther FurthvHerthaBundesliga · Germany | 2–1 | Bundesliga · Germany |
| 2022-02-12 | AlloavEast FifeLeague One · Scotland | 1–3 | League One · Scotland |
| 2022-02-12 | PerugiavFrosinoneSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-02-12 | ClydevDumbartonLeague One · Scotland | 1–3 | League One · Scotland |
| 2022-02-12 | NapolivInterSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-12 | Atl. San LuisvTolucaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2022-02-12 | RochdalevHarrogateLeague Two · England | 3–3 | League Two · England |
| 2022-02-12 | MechelenvOostendePro League · Belgium | 3–0 | Pro League · Belgium |
| 2022-02-12 | MontpelliervLilleLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-12 | Ath MadridvGetafeLa Liga · Spain | 4–3 | La Liga · Spain |
| 2022-02-12 | BanfieldvSan LorenzoCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-12 | IbizavCartagenaLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-02-12 | Kings LynnvAltrinchamNational League · England | 0–1 | National League · England |
| 2022-02-12 | PortsmouthvDoncasterLeague One · England | 4–0 | League One · England |
| 2022-02-12 | LeverkusenvStuttgartBundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2022-02-12 | MorecambevGillinghamLeague One · England | 1–1 | League One · England |
| 2022-02-12 | AFC WimbledonvSunderlandLeague One · England | 1–1 | League One · England |
| 2022-02-12 | LausannevGrasshoppersSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2022-02-12 | BuyuksehyrvGaziantepSüper Lig · Turkey | 2–0 | Süper Lig · Turkey |
| 2022-02-12 | MirandesvSp GijonLa Liga 2 · Spain | 0–3 | La Liga 2 · Spain |
| 2022-02-12 | Nott'm ForestvStokeChampionship · England | 2–2 | Championship · England |
| 2022-02-12 | CambuurvZwolleEredivisie · Netherlands | 3–4 | Eredivisie · Netherlands |
| 2022-02-12 | PeterborovPrestonChampionship · England | 0–1 | Championship · England |