| 2021-02-28 | CadizvBetisLa Liga · Spain | 0–1 | La Liga · Spain |
| 2021-02-28 | PanathinaikosvAEKSuper League · Greece | 1–1 | Super League · Greece |
| 2021-02-28 | SampdoriavAtalantaSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-02-28 | ChelseavMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2021-02-28 | LarisavPanetolikosSuper League · Greece | 1–0 | Super League · Greece |
| 2021-02-28 | Sheffield UnitedvLiverpoolPremier League · England | 0–2 | Premier League · England |
| 2021-02-28 | LeverkusenvFreiburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2021-02-28 | MainzvAugsburgBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2021-02-28 | LillevStrasbourgLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-02-28 | San LorenzovCentral CordobaCopa De La Liga Profesional · Argentina | 0–4 | Copa De La Liga Profesional · Argentina |
| 2021-02-28 | NacionalvSp BragaPrimeira Liga · Portugal | 1–2 | Primeira Liga · Portugal |
| 2021-02-28 | Akhmat GroznyvDynamo MoscowPremier League · Russia | 1–2 | Premier League · Russia |
| 2021-02-28 | WycombevNorwichChampionship · England | 0–2 | Championship · England |
| 2021-02-28 | MidtjyllandvBrondbySuperliga · Denmark | 1–0 | Superliga · Denmark |
| 2021-02-28 | SandhausenvOsnabruck2. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2021-02-28 | Club AmericavPachucaLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-02-28 | HeidenheimvFortuna Dusseldorf2. Bundesliga · Germany | 3–2 | 2. Bundesliga · Germany |
| 2021-02-28 | LorientvSt EtienneLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-02-28 | RomavMilanSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-02-28 | FuenlabradavGironaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2021-02-28 | TondelavGil VicentePrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2021-02-28 | OviedovZaragozaLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2021-02-28 | ReimsvMontpellierLigue 1 · France | 0–0 | Ligue 1 · France |
| 2021-02-28 | NapolivBeneventoSerie A · Italy | 2–0 | Serie A · Italy |
| 2021-02-28 | CrotonevCagliariSerie A · Italy | 0–2 | Serie A · Italy |
| 2021-02-28 | Spartak MoscowvRubin KazanPremier League · Russia | 0–2 | Premier League · Russia |
| 2021-02-28 | TenerifevAlcorconLa Liga 2 · Spain | 3–1 | La Liga 2 · Spain |
| 2021-02-28 | St. PoltenvAustria ViennaBundesliga · Austria | 0–2 | Bundesliga · Austria |
| 2021-02-28 | LausannevLuganoSuper League · Switzerland | 2–0 | Super League · Switzerland |
| 2021-02-28 | CracoviavZaglebieEkstraklasa · Poland | 2–4 | Ekstraklasa · Poland |
| 2021-02-28 | PSV EindhovenvAjaxEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2021-02-28 | NurnbergvBraunschweig2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2021-02-28 | St TruidenvEupenPro League · Belgium | 0–2 | Pro League · Belgium |
| 2021-02-28 | Union BerlinvHoffenheimBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-02-28 | NordsjaellandvAalborgSuperliga · Denmark | 2–2 | Superliga · Denmark |
| 2021-02-28 | Wisla PlockvWislaEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2021-02-28 | FC BotosanivFCSBSuperliga · Romania | 0–2 | Superliga · Romania |
| 2021-02-28 | Slask WroclawvPogon SzczecinEkstraklasa · Poland | 2–1 | Ekstraklasa · Poland |
| 2021-02-28 | TottenhamvBurnleyPremier League · England | 4–0 | Premier League · England |
| 2021-02-28 | AZ AlkmaarvFeyenoordEredivisie · Netherlands | 4–2 | Eredivisie · Netherlands |
| 2021-02-28 | UdinesevFiorentinaSerie A · Italy | 1–0 | Serie A · Italy |
| 2021-02-28 | PlatensevRiver PlateCopa De La Liga Profesional · Argentina | 0–1 | Copa De La Liga Profesional · Argentina |
| 2021-02-28 | Sparta RotterdamvWillem IIEredivisie · Netherlands | 0–2 | Eredivisie · Netherlands |
| 2021-02-28 | AngersvLensLigue 1 · France | 2–2 | Ligue 1 · France |
| 2021-02-28 | Sturm GrazvSalzburgBundesliga · Austria | 2–1 | Bundesliga · Austria |
| 2021-02-28 | Crystal PalacevFulhamPremier League · England | 0–0 | Premier League · England |
| 2021-02-28 | VillarrealvAth MadridLa Liga · Spain | 0–2 | La Liga · Spain |
| 2021-02-28 | CeltavValladolidLa Liga · Spain | 1–1 | La Liga · Spain |
| 2021-02-28 | LuzernvYoung BoysSuper League · Switzerland | 2–2 | Super League · Switzerland |
| 2021-02-28 | GroningenvFor SittardEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |