| 2022-02-14 | Univ. CraiovavU Craiova 1948Superliga · Romania | 2–0 | Superliga · Romania |
| 2022-02-14 | GianninavArisSuper League · Greece | 2–0 | Super League · Greece |
| 2022-02-14 | FC BotosanivAcademica ClinceniSuperliga · Romania | 2–0 | Superliga · Romania |
| 2022-02-14 | Ad. DemirsporvBesiktasSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2022-02-13 | St. GilloisevSt TruidenPro League · Belgium | 0–1 | Pro League · Belgium |
| 2022-02-13 | AtalantavJuventusSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-13 | ZurichvLuganoSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2022-02-13 | Sparta RotterdamvWillem IIEredivisie · Netherlands | 1–0 | Eredivisie · Netherlands |
| 2022-02-13 | Club BruggevCharleroiPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-02-13 | Racing ClubvGimnasia L.P.Copa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-13 | ClermontvSt EtienneLigue 1 · France | 1–2 | Ligue 1 · France |
| 2022-02-13 | PanathinaikosvLamiaSuper League · Greece | 2–0 | Super League · Greece |
| 2022-02-13 |  MonacovLorientLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-02-13 | KasimpasavAlanyasporSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2022-02-13 | LegiavWarta PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-02-13 | Young BoysvBaselSuper League · Switzerland | 3–1 | Super League · Switzerland |
| 2022-02-13 | BurnleyvLiverpoolPremier League · England | 0–1 | Premier League · England |
| 2022-02-13 | GenkvStandardPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-02-13 | AlavesvValenciaLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-02-13 | SwanseavBristol CityChampionship · England | 3–1 | Championship · England |
| 2022-02-13 | TottenhamvWolvesPremier League · England | 0–2 | Premier League · England |
| 2022-02-13 | FamalicaovMoreirensePrimeira Liga · Portugal | 5–0 | Primeira Liga · Portugal |
| 2022-02-13 | GenoavSalernitanaSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-13 | AngersvStrasbourgLigue 1 · France | 0–1 | Ligue 1 · France |
| 2022-02-13 | LugovAmorebietaLa Liga 2 · Spain | 1–1 | La Liga 2 · Spain |
| 2022-02-13 | LeicestervWest HamPremier League · England | 2–2 | Premier League · England |
| 2022-02-13 | FC ArgesvMioveniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2022-02-13 | VizelavGil VicentePrimeira Liga · Portugal | 0–1 | Primeira Liga · Portugal |
| 2022-02-13 | TrabzonsporvKonyasporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-02-13 | Las PalmasvBurgosLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2022-02-13 | NantesvReimsLigue 1 · France | 1–0 | Ligue 1 · France |
| 2022-02-13 | HannovervDarmstadt2. Bundesliga · Germany | 2–2 | 2. Bundesliga · Germany |
| 2022-02-13 | LeccevBeneventoSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-13 | Beerschot VAvKortrijkPro League · Belgium | 2–1 | Pro League · Belgium |
| 2022-02-13 | FCSBvChindia TargovisteSuperliga · Romania | 3–2 | Superliga · Romania |
| 2022-02-13 | HeerenveenvNijmegenEredivisie · Netherlands | 0–1 | Eredivisie · Netherlands |
| 2022-02-13 | BresciavAlessandriaSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-13 | Sheffield WedsvRotherhamLeague One · England | 0–2 | League One · England |
| 2022-02-13 | IngolstadtvSandhausen2. Bundesliga · Germany | 0–0 | 2. Bundesliga · Germany |
| 2022-02-13 | BelenensesvGuimaraesPrimeira Liga · Portugal | 1–0 | Primeira Liga · Portugal |
| 2022-02-13 | Union BerlinvDortmundBundesliga · Germany | 0–3 | Bundesliga · Germany |
| 2022-02-13 | AlcorconvTenerifeLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2022-02-13 | VeronavUdineseSerie A · Italy | 4–0 | Serie A · Italy |
| 2022-02-13 | OFI CretevVolos NFCSuper League · Greece | 2–1 | Super League · Greece |
| 2022-02-13 | LuzernvSionSuper League · Switzerland | 1–0 | Super League · Switzerland |
| 2022-02-13 | AntalyasporvKaragumrukSüper Lig · Turkey | 3–0 | Süper Lig · Turkey |
| 2022-02-13 | LASKvA. KlagenfurtBundesliga · Austria | 2–2 | Bundesliga · Austria |
| 2022-02-13 | NewcastlevAston VillaPremier League · England | 1–0 | Premier League · England |
| 2022-02-13 | Cruz AzulvNecaxaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2022-02-13 | MilanvSampdoriaSerie A · Italy | 1–0 | Serie A · Italy |