| 2022-02-16 | AlessandriavLecceSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-16 | BeneventovAscoliSerie B · Italy | 0–2 | Serie B · Italy |
| 2022-02-16 | PanetolikosvLamiaSuper League · Greece | 1–0 | Super League · Greece |
| 2022-02-16 | AldosivivBoca JuniorsCopa De La Liga Profesional · Argentina | 1–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-16 | GenkvMechelenPro League · Belgium | 4–1 | Pro League · Belgium |
| 2022-02-16 | PeterborovReadingChampionship · England | 0–0 | Championship · England |
| 2022-02-16 | TigrevCentral CordobaCopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-16 | LanusvBarracas CentralCopa De La Liga Profesional · Argentina | 2–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-16 | ApollonvPanathinaikosSuper League · Greece | 0–3 | Super League · Greece |
| 2022-02-16 | CrotonevBresciaSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-02-16 | AtromitosvOFI CreteSuper League · Greece | 2–2 | Super League · Greece |
| 2022-02-16 | Ath MadridvLevanteLa Liga · Spain | 0–1 | La Liga · Spain |
| 2022-02-16 | FrosinonevComoSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-02-15 | IndependientevArsenal SarandiCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-15 | Argentinos JrsvNewells Old BoysCopa De La Liga Profesional · Argentina | 3–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-15 | Edinburgh CityvAlbion RvsLeague Two · Scotland | 1–2 | League Two · Scotland |
| 2022-02-15 | CosenzavPerugiaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-02-15 | ExetervHarrogateLeague Two · England | 4–3 | League Two · England |
| 2022-02-15 | WeymouthvEastleighNational League · England | 1–0 | National League · England |
| 2022-02-15 | StirlingvForfarLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2022-02-15 | PisavVicenzaSerie B · Italy | 2–2 | Serie B · Italy |
| 2022-02-15 | AberdeenvSt JohnstonePremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-02-15 | PachucavQueretaroLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2022-02-15 | LincolnvDoncasterLeague One · England | 0–1 | League One · England |
| 2022-02-15 | Man UnitedvBrightonPremier League · England | 2–0 | Premier League · England |
| 2022-02-15 | MillwallvQPRChampionship · England | 2–0 | Championship · England |
| 2022-02-15 | ElginvAnnan AthleticLeague Two · Scotland | 0–2 | League Two · Scotland |
| 2022-02-15 | CremonesevParmaSerie B · Italy | 3–1 | Serie B · Italy |
| 2022-02-15 | Rosario CentralvVelez SarsfieldCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-15 | SpalvRegginaSerie B · Italy | 1–3 | Serie B · Italy |
| 2022-02-15 | CardiffvCoventryChampionship · England | 2–0 | Championship · England |
| 2022-02-15 | BurtonvBoltonLeague One · England | 3–1 | League One · England |
| 2022-02-15 | WiganvCreweLeague One · England | 2–0 | League One · England |
| 2022-02-15 | Sheffield UnitedvHullChampionship · England | 0–0 | Championship · England |
| 2022-02-15 | BromleyvStockportNational League · England | 1–3 | National League · England |
| 2022-02-15 | TernanavMonzaSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-02-15 | HartlepoolvTranmereLeague Two · England | 1–0 | League Two · England |
| 2022-02-15 | Bristol RvsvSuttonLeague Two · England | 2–0 | League Two · England |
| 2022-02-15 | GrenoblevNiortLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-02-15 | Boreham WoodvAltrinchamNational League · England | 2–0 | National League · England |
| 2022-02-15 | PordenonevCittadellaSerie B · Italy | 0–1 | Serie B · Italy |
| 2022-02-14 | AroucavMaritimoPrimeira Liga · Portugal | 0–3 | Primeira Liga · Portugal |
| 2022-02-14 | Gornik Z.vJagielloniaEkstraklasa · Poland | 1–2 | Ekstraklasa · Poland |
| 2022-02-14 | Le HavrevBastiaLigue 2 · France | 2–4 | Ligue 2 · France |
| 2022-02-14 | PonferradinavSociedad BLa Liga 2 · Spain | 3–2 | La Liga 2 · Spain |
| 2022-02-14 | MallorcavAth BilbaoLa Liga · Spain | 3–2 | La Liga · Spain |
| 2022-02-14 | SpeziavFiorentinaSerie A · Italy | 1–2 | Serie A · Italy |
| 2022-02-14 | West BromvBlackburnChampionship · England | 0–0 | Championship · England |
| 2022-02-14 | Boca JuniorsvColon Santa FECopa De La Liga Profesional · Argentina | 1–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-14 | HataysporvGoztepSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |