| 2021-03-07 | Ath MadridvReal MadridLaLiga · Spain | 1–1 | LaLiga · Spain |
| 2021-03-07 | FC KolnvWerder BremenBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2021-03-07 | PanetolikosvVolos NFCSuper League Greece · Greece | 1–0 | Super League Greece · Greece |
| 2021-03-07 | SociedadvLevanteLaLiga · Spain | 1–0 | LaLiga · Spain |
| 2021-03-07 | AnderlechtvMechelenPro League · Belgium | 1–1 | Pro League · Belgium |
| 2021-03-07 | Mazatlan FCvGuadalajara ChivasLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-03-07 | VejlevOdenseDanish Superliga · Denmark | 2–0 | Danish Superliga · Denmark |
| 2021-03-07 | RiedvWolfsberger ACAustrian Bundesliga · Austria | 0–4 | Austrian Bundesliga · Austria |
| 2021-03-07 | HuescavCeltaLaLiga · Spain | 3–4 | LaLiga · Spain |
| 2021-03-07 | HeraclesvZwolleEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2021-03-07 | Pogon SzczecinvLech PoznanEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2021-03-07 | ReggianavLecceSerie B · Italy | 0–4 | Serie B · Italy |
| 2021-03-07 | AstravFC HermannstadtLiga I · Romania | 2–1 | Liga I · Romania |
| 2021-03-07 | Dynamo MoscowvTambovRussian Premier League · Russia | 2–0 | Russian Premier League · Russia |
| 2021-03-07 | Austria ViennavSK RapidAustrian Bundesliga · Austria | 0–0 | Austrian Bundesliga · Austria |
| 2021-03-07 | Club BruggevWaregemPro League · Belgium | 3–0 | Pro League · Belgium |
| 2021-03-07 | Club AmericavClub LeonLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2021-03-06 | NorthamptonvPortsmouthLeague One · England | 4–1 | League One · England |
| 2021-03-06 | TokushimavVissel KobeJ1 League · Japan | 1–1 | J1 League · Japan |
| 2021-03-06 | Bristol CityvQPRChampionship · England | 0–2 | Championship · England |
| 2021-03-06 | AtromitosvAsteras TripolisSuper League Greece · Greece | 1–1 | Super League Greece · Greece |
| 2021-03-06 | WatfordvNott'm ForestChampionship · England | 1–0 | Championship · England |
| 2021-03-06 | ReadingvSheffield WedsChampionship · England | 3–0 | Championship · England |
| 2021-03-06 | WiganvMilton Keynes DonsLeague One · England | 3–0 | League One · England |
| 2021-03-06 | Sheffield UnitedvSouthamptonPremier League · England | 0–2 | Premier League · England |
| 2021-03-06 | ServettevBaselSwiss Super League · Switzerland | 2–1 | Swiss Super League · Switzerland |
| 2021-03-06 | ArbroathvQueen of SthChampionship · Scotland | 2–4 | Championship · Scotland |
| 2021-03-06 | OxfordvCharltonLeague One · England | 0–0 | League One · England |
| 2021-03-06 | BlackpoolvAFC WimbledonLeague One · England | 1–1 | League One · England |
| 2021-03-06 | Erzgebirge AuevHannover2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2021-03-06 | WokingvKings LynnNational League · England | 3–0 | National League · England |
| 2021-03-06 | WealdstonevHalifaxNational League · England | 1–2 | National League · England |
| 2021-03-06 | CSKA MoscowvAkhmat GroznyRussian Premier League · Russia | 2–0 | Russian Premier League · Russia |
| 2021-03-06 | ZaragozavTenerifeLaLiga 2 · Spain | 1–0 | LaLiga 2 · Spain |
| 2021-03-06 | PodbeskidzievLechia GdanskEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-03-06 | Bayern MunichvDortmundBundesliga · Germany | 4–2 | Bundesliga · Germany |
| 2021-03-06 | JuventusvLazioSerie A · Italy | 3–1 | Serie A · Italy |
| 2021-03-06 | StevenagevHarrogateLeague Two · England | 1–0 | League Two · England |
| 2021-03-06 | ElchevSevillaLaLiga · Spain | 2–1 | LaLiga · Spain |
| 2021-03-06 | WeymouthvStockportNational League · England | 1–0 | National League · England |
| 2021-03-06 | BurnleyvArsenalPremier League · England | 1–1 | Premier League · England |
| 2021-03-06 | PueblavTigres UANLLiga MX · Mexico | 1–1 | Liga MX · Mexico |
| 2021-03-06 | SuttonvWrexhamNational League · England | 0–0 | National League · England |
| 2021-03-06 | DenizlisporvYeni MalatyasporSüper Lig · Türkiye | 3–2 | Süper Lig · Türkiye |
| 2021-03-06 | BesiktasvGaziantepSüper Lig · Türkiye | 2–1 | Süper Lig · Türkiye |
| 2021-03-06 | SwanseavMiddlesbroughChampionship · England | 2–1 | Championship · England |
| 2021-03-06 | AtlasvJuarezLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2021-03-06 | PortimonensevTondelaPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2021-03-06 | BurtonvPeterboroLeague One · England | 2–1 | League One · England |
| 2021-03-06 | FC TokyovCerezo OsakaJ1 League · Japan | 3–2 | J1 League · Japan |