| 2022-02-19 | Holstein KielvKarlsruhe2. Bundesliga · Germany | 0–2 | 2. Bundesliga · Germany |
| 2022-02-19 | HibernianvRoss CountyPremiership · Scotland | 2–0 | Premiership · Scotland |
| 2022-02-19 | Shimizu S-PulsevHokkaido Consadole SapporoJ1 League · Japan | 1–1 | J1 League · Japan |
| 2022-02-19 | ParmavTernanaSerie B · Italy | 2–3 | Serie B · Italy |
| 2022-02-19 | CharltonvOxfordLeague One · England | 0–4 | League One · England |
| 2022-02-19 | LutonvWest BromChampionship · England | 2–0 | Championship · England |
| 2022-02-19 | StuttgartvBochumBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2022-02-19 | NiortvAuxerreLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-02-19 | CharleroivSt. GilloisePro League · Belgium | 0–3 | Pro League · Belgium |
| 2022-02-19 | Cercle BruggevBeerschot VAPro League · Belgium | 2–0 | Pro League · Belgium |
| 2022-02-19 | DumbartonvAlloaLeague One · Scotland | 1–2 | League One · Scotland |
| 2022-02-19 | Sanfrecce HiroshimavSagan TosuJ1 League · Japan | 0–0 | J1 League · Japan |
| 2022-02-19 | ZaragozavLas PalmasLa Liga 2 · Spain | 2–1 | La Liga 2 · Spain |
| 2022-02-19 | AZ AlkmaarvHeraclesEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2022-02-19 | Shonan BellmarevKashiwa ReysolJ1 League · Japan | 0–2 | J1 League · Japan |
| 2022-02-19 | MontrosevClydeLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-02-19 | MaidenheadvBoreham WoodNational League · England | 2–0 | National League · England |
| 2022-02-19 | LivingstonvSt MirrenPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-02-19 | SouthamptonvEvertonPremier League · England | 2–0 | Premier League · England |
| 2022-02-19 | ChesterfieldvSolihullNational League · England | 2–3 | National League · England |
| 2022-02-18 | Kawasaki FrontalevFC TokyoJ1 League · Japan | 1–0 | J1 League · Japan |
| 2022-02-18 | JuventusvTorinoSerie A · Italy | 1–1 | Serie A · Italy |
| 2022-02-18 | Shamrock RoversvUC DublinPremier Division · Ireland | 3–0 | Premier Division · Ireland |
| 2022-02-18 | RotherhamvWiganLeague One · England | 1–1 | League One · England |
| 2022-02-18 | SonderjyskevAarhusSuperliga · Denmark | 2–3 | Superliga · Denmark |
| 2022-02-18 | BoavistavBenficaPrimeira Liga · Portugal | 2–2 | Primeira Liga · Portugal |
| 2022-02-18 | LillevMetzLigue 1 · France | 0–0 | Ligue 1 · France |
| 2022-02-18 | Din. BucurestivGaz Metan MediasSuperliga · Romania | 4–0 | Superliga · Romania |
| 2022-02-18 | ElchevVallecanoLa Liga · Spain | 2–1 | La Liga · Spain |
| 2022-02-18 | ZaglebievWisla PlockEkstraklasa · Poland | 3–1 | Ekstraklasa · Poland |
| 2022-02-18 | KonyasporvKasimpasaSüper Lig · Turkey | 4–4 | Süper Lig · Turkey |
| 2022-02-18 | Schalke 04vPaderborn2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-02-18 | DresdenvHeidenheim2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-02-18 | U Craiova 1948vUTA AradSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-18 | Talleres CordobavUnion de Santa FeCopa De La Liga Profesional · Argentina | 0–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-18 | MainzvLeverkusenBundesliga · Germany | 3–2 | Bundesliga · Germany |
| 2022-02-18 | Atl. TucumanvPlatenseCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-18 | DundalkvDerry CityPremier Division · Ireland | 2–2 | Premier Division · Ireland |
| 2022-02-18 | CartagenavValladolidLa Liga 2 · Spain | 2–3 | La Liga 2 · Spain |
| 2022-02-18 | Stal MielecvPogon SzczecinEkstraklasa · Poland | 0–1 | Ekstraklasa · Poland |
| 2022-02-18 | RizesporvBuyuksehyrSüper Lig · Turkey | 0–2 | Süper Lig · Turkey |
| 2022-02-18 | ShelbournevSt. PatricksPremier Division · Ireland | 0–3 | Premier Division · Ireland |
| 2022-02-17 | Defensa y JusticiavRacing ClubCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-17 | River PlatevPatronatoCopa De La Liga Profesional · Argentina | 4–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-17 | Mazatlan FCvClub AmericaLiga MX · Mexico | 2–1 | Liga MX · Mexico |
| 2022-02-17 | Gimnasia L.P.vSan LorenzoCopa De La Liga Profesional · Argentina | 1–0 | Copa De La Liga Profesional · Argentina |
| 2022-02-17 | Sarmiento JuninvBanfieldCopa De La Liga Profesional · Argentina | 2–2 | Copa De La Liga Profesional · Argentina |
| 2022-02-17 | Colon Santa FEvGodoy CruzCopa De La Liga Profesional · Argentina | 3–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-17 | Academica ClincenivFarul ConstantaSuperliga · Romania | 2–8 | Superliga · Romania |
| 2022-02-16 | HuracanvEstudiantes L.P.Copa De La Liga Profesional · Argentina | 2–3 | Copa De La Liga Profesional · Argentina |