| 2021-03-04 | LiverpoolvChelseaPremier League · England | 0–1 | Premier League · England |
| 2021-03-04 | FenerbahcevAntalyasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-03-04 | Stal MielecvWisla PlockEkstraklasa · Poland | 2–2 | Ekstraklasa · Poland |
| 2021-03-04 | Club TijuanavClub AmericaLiga MX · Mexico | 0–2 | Liga MX · Mexico |
| 2021-03-04 | FulhamvTottenhamPremier League · England | 0–1 | Premier League · England |
| 2021-03-04 | SionvLuganoSuper League · Switzerland | 0–3 | Super League · Switzerland |
| 2021-03-04 | AlanyasporvGoztepSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-03-04 | SonderjyskevOdenseSuperliga · Denmark | 1–1 | Superliga · Denmark |
| 2021-03-04 | LyngbyvMidtjyllandSuperliga · Denmark | 2–0 | Superliga · Denmark |
| 2021-03-04 | Cruz AzulvMazatlan FCLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2021-03-04 | BrondbyvRanders FCSuperliga · Denmark | 0–0 | Superliga · Denmark |
| 2021-03-04 | QueretarovGuadalajara ChivasLiga MX · Mexico | 2–2 | Liga MX · Mexico |
| 2021-03-04 | ZurichvLuzernSuper League · Switzerland | 1–2 | Super League · Switzerland |
| 2021-03-04 | KasimpasavTrabzonsporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2021-03-04 | West BromvEvertonPremier League · England | 0–1 | Premier League · England |
| 2021-03-03 | StokevSwanseaChampionship · England | 1–2 | Championship · England |
| 2021-03-03 | GenoavSampdoriaSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-03-03 | Strasbourgv MonacoLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-03-03 | HamiltonvSt JohnstonePremiership · Scotland | 1–1 | Premiership · Scotland |
| 2021-03-03 | KayserisporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-03-03 | SivassporvHataysporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-03-03 | Sheffield UnitedvAston VillaPremier League · England | 1–0 | Premier League · England |
| 2021-03-03 | NorwichvBrentfordChampionship · England | 1–0 | Championship · England |
| 2021-03-03 | BeneventovVeronaSerie A · Italy | 0–3 | Serie A · Italy |
| 2021-03-03 | Erzurum BBvKaragumrukSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2021-03-03 | NicevNimesLigue 1 · France | 2–1 | Ligue 1 · France |
| 2021-03-03 | BaselvYoung BoysSuper League · Switzerland | 1–1 | Super League · Switzerland |
| 2021-03-03 | HorsensvAalborgSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-03-03 | FC CopenhagenvVejleSuperliga · Denmark | 2–1 | Superliga · Denmark |
| 2021-03-03 | Sheffield WedsvRotherhamChampionship · England | 1–2 | Championship · England |
| 2021-03-03 | MontpelliervLorientLigue 1 · France | 1–1 | Ligue 1 · France |
| 2021-03-03 | MilanvUdineseSerie A · Italy | 1–1 | Serie A · Italy |
| 2021-03-03 | Crystal PalacevMan UnitedPremier League · England | 0–0 | Premier League · England |
| 2021-03-03 | AnkaragucuvGalatasaraySüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2021-03-03 | LillevMarseilleLigue 1 · France | 2–0 | Ligue 1 · France |
| 2021-03-03 | VaduzvLausanneSuper League · Switzerland | 0–3 | Super League · Switzerland |
| 2021-03-03 | Bristol CityvBournemouthChampionship · England | 1–2 | Championship · England |
| 2021-03-03 | BurnleyvLeicesterPremier League · England | 1–1 | Premier League · England |
| 2021-03-03 | AtalantavCrotoneSerie A · Italy | 5–1 | Serie A · Italy |
| 2021-03-03 | AarhusvNordsjaellandSuperliga · Denmark | 0–1 | Superliga · Denmark |
| 2021-03-03 | BuyuksehyrvKonyasporSüper Lig · Turkey | 1–1 | Süper Lig · Turkey |
| 2021-03-03 | Tigres UANLvTolucaLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2021-03-03 | FiorentinavRomaSerie A · Italy | 1–2 | Serie A · Italy |
| 2021-03-03 | Kawasaki FrontalevCerezo OsakaJ1 League · Japan | 3–2 | J1 League · Japan |
| 2021-03-03 | WatfordvWycombeChampionship · England | 2–0 | Championship · England |
| 2021-03-03 | QPRvBarnsleyChampionship · England | 1–3 | Championship · England |
| 2021-03-03 | LyonvRennesLigue 1 · France | 1–0 | Ligue 1 · France |
| 2021-03-03 | SassuolovNapoliSerie A · Italy | 3–3 | Serie A · Italy |
| 2021-03-03 | BordeauxvParis SGLigue 1 · France | 0–1 | Ligue 1 · France |
| 2021-03-03 | NantesvReimsLigue 1 · France | 1–2 | Ligue 1 · France |