| 2016-02-21 | LeverkusenvDortmundBundesliga · Germany | 0–1 | Bundesliga · Germany |
| 2016-02-21 | Godoy CruzvColon Santa FELiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2016-02-21 | Waasland-BeverenvAnderlechtPro League · Belgium | 1–0 | Pro League · Belgium |
| 2016-02-21 | Boca JuniorsvNewells Old BoysLiga Profesional · Argentina | 4–1 | Liga Profesional · Argentina |
| 2016-02-21 | GrasshoppersvSionSwiss Super League · Switzerland | 3–0 | Swiss Super League · Switzerland |
| 2016-02-21 | SalernitanavCrotoneSerie B · Italy | 1–1 | Serie B · Italy |
| 2016-02-21 | UtrechtvWillem IIEredivisie · Netherlands | 2–1 | Eredivisie · Netherlands |
| 2016-02-21 | SassuolovEmpoliSerie A · Italy | 3–2 | Serie A · Italy |
| 2016-02-21 | LuzernvSt. GallenSwiss Super League · Switzerland | 0–1 | Swiss Super League · Switzerland |
| 2016-02-21 | CFR ClujvTargu MuresLiga I · Romania | 1–0 | Liga I · Romania |
| 2016-02-20 | EspanolvLa CorunaLaLiga · Spain | 1–0 | LaLiga · Spain |
| 2016-02-20 | IngolstadtvWerder BremenBundesliga · Germany | 2–0 | Bundesliga · Germany |
| 2016-02-20 | Bayern MunichvDarmstadtBundesliga · Germany | 3–1 | Bundesliga · Germany |
| 2016-02-20 | PSV EindhovenvHeraclesEredivisie · Netherlands | 2–0 | Eredivisie · Netherlands |
| 2016-02-20 | Austria ViennavMattersburgAustrian Bundesliga · Austria | 2–2 | Austrian Bundesliga · Austria |
| 2016-02-20 | Welling UnitedvWrexhamNational League · England | 0–2 | National League · England |
| 2016-02-20 | Mouscron-PeruwelzvOud-Heverlee LeuvenPro League · Belgium | 3–1 | Pro League · Belgium |
| 2016-02-20 | AyrvForfarLeague One · Scotland | 2–1 | League One · Scotland |
| 2016-02-20 | Ross CountyvHamiltonPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2016-02-20 | MontrosevElginLeague Two · Scotland | 3–1 | League Two · Scotland |
| 2016-02-20 | AlcorconvAth Bilbao BLaLiga 2 · Spain | 1–0 | LaLiga 2 · Spain |
| 2016-02-20 | SpeziavVirtus LancianoSerie B · Italy | 2–0 | Serie B · Italy |
| 2016-02-20 | BradfordvRochdaleLeague One · England | 2–2 | League One · England |
| 2016-02-20 | BurnleyvRotherhamChampionship · England | 2–0 | Championship · England |
| 2016-02-20 | Young BoysvThunSwiss Super League · Switzerland | 2–1 | Swiss Super League · Switzerland |
| 2016-02-20 | AscolivComoSerie B · Italy | 1–0 | Serie B · Italy |
| 2016-02-20 | CambridgevYorkLeague Two · England | 3–1 | League Two · England |
| 2016-02-20 | NorthamptonvWycombeLeague Two · England | 1–0 | League Two · England |
| 2016-02-20 | SalzburgvAltachAustrian Bundesliga · Austria | 2–0 | Austrian Bundesliga · Austria |
| 2016-02-20 | Wolfsberger ACvGrodigAustrian Bundesliga · Austria | 2–0 | Austrian Bundesliga · Austria |
| 2016-02-20 | Forest GreenvEastleighNational League · England | 2–1 | National League · England |
| 2016-02-20 | BursasporvFenerbahceSüper Lig · Türkiye | 0–0 | Süper Lig · Türkiye |
| 2016-02-20 | ArbroathvQueens ParkLeague Two · Scotland | 0–1 | League Two · Scotland |
| 2016-02-20 | PrestonvSheffield WedsChampionship · England | 1–0 | Championship · England |
| 2016-02-20 | ChesterfieldvCreweLeague One · England | 3–1 | League One · England |
| 2016-02-20 | LivornovCesenaSerie B · Italy | 1–1 | Serie B · Italy |
| 2016-02-20 | TranmerevCheltenhamNational League · England | 0–1 | National League · England |
| 2016-02-20 | KilmarnockvDundeePremiership · Scotland | 0–0 | Premiership · Scotland |
| 2016-02-20 | PodbeskidzievLech PoznanEkstraklasa · Poland | 4–1 | Ekstraklasa · Poland |
| 2016-02-20 | BromleyvWokingNational League · England | 2–1 | National League · England |
| 2016-02-20 | BetisvSp GijonLaLiga · Spain | 1–1 | LaLiga · Spain |
| 2016-02-20 | CarlislevStevenageLeague Two · England | 1–0 | League Two · England |
| 2016-02-20 | HerthavWolfsburgBundesliga · Germany | 1–1 | Bundesliga · Germany |
| 2016-02-20 | IraklisvAEKSuper League Greece · Greece | 1–1 | Super League Greece · Greece |
| 2016-02-20 | Boreham WoodvTorquayNational League · England | 0–1 | National League · England |
| 2016-02-20 | SwindonvBlackpoolLeague One · England | 3–2 | League One · England |
| 2016-02-20 | LevadeiakosvKallonisSuper League Greece · Greece | 1–0 | Super League Greece · Greece |
| 2016-02-20 | BrechinvDunfermlineLeague One · Scotland | 1–2 | League One · Scotland |
| 2016-02-20 | MallorcavGimnasticLaLiga 2 · Spain | 2–2 | LaLiga 2 · Spain |
| 2016-02-20 | St JohnstonevMotherwellPremiership · Scotland | 2–1 | Premiership · Scotland |