| 2016-02-14 | AugsburgvBayern MunichBundesliga · Germany | 1–3 | Bundesliga · Germany |
| 2016-02-14 | MaritimovSp BragaPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2016-02-14 | Poli TimisoaravFC VoluntariSuperliga · Romania | 1–2 | Superliga · Romania |
| 2016-02-14 | Velez SarsfieldvOlimpo Bahia BlancaLiga Profesional · Argentina | 2–1 | Liga Profesional · Argentina |
| 2016-02-14 | Din. BucurestivFC BotosaniSuperliga · Romania | 1–0 | Superliga · Romania |
| 2016-02-14 | Man CityvTottenhamPremier League · England | 1–2 | Premier League · England |
| 2016-02-14 | CordobavZaragozaLa Liga 2 · Spain | 0–2 | La Liga 2 · Spain |
| 2016-02-14 | Aston VillavLiverpoolPremier League · England | 0–6 | Premier League · England |
| 2016-02-14 | EstorilvTondelaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2016-02-14 | GianninavPanathinaikosSuper League · Greece | 0–3 | Super League · Greece |
| 2016-02-14 | FreiburgvFortuna Dusseldorf2. Bundesliga · Germany | 1–2 | 2. Bundesliga · Germany |
| 2016-02-14 | SociedadvGranadaLa Liga · Spain | 3–0 | La Liga · Spain |
| 2016-02-14 | LegiavJagielloniaEkstraklasa · Poland | 4–0 | Ekstraklasa · Poland |
| 2016-02-14 | SampdoriavAtalantaSerie A · Italy | 0–0 | Serie A · Italy |
| 2016-02-14 | OviedovTenerifeLa Liga 2 · Spain | 1–0 | La Liga 2 · Spain |
| 2016-02-14 | PAOKvIraklisSuper League · Greece | 0–1 | Super League · Greece |
| 2016-02-14 | BraunschweigvBielefeld2. Bundesliga · Germany | 1–0 | 2. Bundesliga · Germany |
| 2016-02-14 | PanetolikosvLevadeiakosSuper League · Greece | 2–0 | Super League · Greece |
| 2016-02-14 | WesterlovStandardPro League · Belgium | 2–0 | Pro League · Belgium |
| 2016-02-14 | ArsenalvLeicesterPremier League · England | 2–1 | Premier League · England |
| 2016-02-14 | St TruidenvMechelenPro League · Belgium | 0–3 | Pro League · Belgium |
| 2016-02-14 | HuescavGironaLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2016-02-14 | MilanvGenoaSerie A · Italy | 2–1 | Serie A · Italy |
| 2016-02-14 | LyonvCaenLigue 1 · France | 4–1 | Ligue 1 · France |
| 2016-02-14 | NicevMarseilleLigue 1 · France | 1–1 | Ligue 1 · France |
| 2016-02-14 | Racing ClubvSan Martin S.J.Liga Profesional · Argentina | 2–2 | Liga Profesional · Argentina |
| 2016-02-14 | Rosario CentralvNewells Old BoysLiga Profesional · Argentina | 2–0 | Liga Profesional · Argentina |
| 2016-02-14 | Guadalajara ChivasvClub LeonLiga MX · Mexico | 0–1 | Liga MX · Mexico |
| 2016-02-14 | GetafevAth MadridLa Liga · Spain | 0–1 | La Liga · Spain |
| 2016-02-14 | PalermovTorinoSerie A · Italy | 1–3 | Serie A · Italy |
| 2016-02-14 | LeganesvOsasunaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2016-02-14 | Austria ViennavSK RapidBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2016-02-14 | SpeziavLivornoSerie B · Italy | 3–0 | Serie B · Italy |
| 2016-02-14 | Gimnasia L.P.vPatronatoLiga Profesional · Argentina | 3–2 | Liga Profesional · Argentina |
| 2016-02-14 | BuyuksehyrvBesiktasSüper Lig · Turkey | 2–2 | Süper Lig · Turkey |
| 2016-02-14 | EskisehirsporvAntalyasporSüper Lig · Turkey | 3–2 | Süper Lig · Turkey |
| 2016-02-14 | Boca JuniorsvAtl. TucumanLiga Profesional · Argentina | 0–1 | Liga Profesional · Argentina |
| 2016-02-14 | U CraiovavPetrolulSuperliga · Romania | 2–0 | Superliga · Romania |
| 2016-02-14 | Tigres UANLvClub TijuanaLiga MX · Mexico | 1–2 | Liga MX · Mexico |
| 2016-02-14 | KallonisvPanioniosSuper League · Greece | 1–1 | Super League · Greece |
| 2016-02-14 | BarcelonavCeltaLa Liga · Spain | 6–1 | La Liga · Spain |
| 2016-02-14 | Union BerlinvMunich 18602. Bundesliga · Germany | 3–0 | 2. Bundesliga · Germany |
| 2016-02-14 | NijmegenvPSV EindhovenEredivisie · Netherlands | 0–3 | Eredivisie · Netherlands |
| 2016-02-14 | NumanciavMallorcaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2016-02-14 | St Etiennev MonacoLigue 1 · France | 1–1 | Ligue 1 · France |
| 2016-02-14 | SivassporvRizesporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2016-02-14 | Lech PoznanvTermalica B-B.Ekstraklasa · Poland | 5–2 | Ekstraklasa · Poland |
| 2016-02-14 | ExcelsiorvDen HaagEredivisie · Netherlands | 2–4 | Eredivisie · Netherlands |
| 2016-02-14 | AroucavUniao MadeiraPrimeira Liga · Portugal | 3–0 | Primeira Liga · Portugal |
| 2016-02-14 | OostendevClub BruggePro League · Belgium | 0–2 | Pro League · Belgium |