| 2022-02-19 | Annan AthleticvEdinburgh CityLeague Two · Scotland | 2–1 | League Two · Scotland |
| 2022-02-19 | Pacos FerreiravVizelaPrimeira Liga · Portugal | 2–1 | Primeira Liga · Portugal |
| 2022-02-19 | WycombevCheltenhamLeague One · England | 5–5 | League One · England |
| 2022-02-19 | Pau FCvCaenLigue 2 · France | 1–0 | Ligue 2 · France |
| 2022-02-19 | East FifevQueens ParkLeague One · Scotland | 1–1 | League One · Scotland |
| 2022-02-19 | RegginavPordenoneSerie B · Italy | 2–0 | Serie B · Italy |
| 2022-02-19 | Arsenal SarandivHuracanCopa De La Liga Profesional · Argentina | 2–1 | Copa De La Liga Profesional · Argentina |
| 2022-02-19 | GillinghamvPlymouthLeague One · England | 0–2 | League One · England |
| 2022-02-19 | SandhausenvHamburg2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-02-19 | StranraervStenhousemuirLeague Two · Scotland | 1–1 | League Two · Scotland |
| 2022-02-19 | Quevilly RouenvValenciennesLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-19 | StockportvWokingNational League · England | 1–0 | National League · England |
| 2022-02-19 | GuingampvParis FCLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-19 | OsasunavAth MadridLa Liga · Spain | 0–3 | La Liga · Spain |
| 2022-02-19 | Cove RangersvFalkirkLeague One · Scotland | 2–0 | League One · Scotland |
| 2022-02-19 | KilmarnockvRaith RvsChampionship · Scotland | 3–0 | Championship · Scotland |
| 2022-02-19 | AugsburgvFreiburgBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-02-19 | BielefeldvUnion BerlinBundesliga · Germany | 1–0 | Bundesliga · Germany |
| 2022-02-19 | Yokohama F. MarinosvCerezo OsakaJ1 League · Japan | 2–2 | J1 League · Japan |
| 2022-02-19 | Slask WroclawvPiast GliwiceEkstraklasa · Poland | 1–3 | Ekstraklasa · Poland |
| 2022-02-19 | KyotovUrawa RedsJ1 League · Japan | 1–0 | J1 League · Japan |
| 2022-02-19 | DerbyvPeterboroChampionship · England | 1–0 | Championship · England |
| 2022-02-19 | ScunthorpevRochdaleLeague Two · England | 1–2 | League Two · England |
| 2022-02-19 | SalernitanavMilanSerie A · Italy | 2–2 | Serie A · Italy |
| 2022-02-19 | WealdstonevWrexhamNational League · England | 1–2 | National League · England |
| 2022-02-19 | RomavVeronaSerie A · Italy | 2–2 | Serie A · Italy |
| 2022-02-19 | JuarezvSantos LagunaLiga MX · Mexico | 0–0 | Liga MX · Mexico |
| 2022-02-19 | NijmegenvWaalwijkEredivisie · Netherlands | 1–1 | Eredivisie · Netherlands |
| 2022-02-19 | MiovenivFCSBSuperliga · Romania | 1–1 | Superliga · Romania |
| 2022-02-19 | SampdoriavEmpoliSerie A · Italy | 2–0 | Serie A · Italy |
| 2022-02-19 | Yeni MalatyasporvAntalyasporSüper Lig · Turkey | 1–2 | Süper Lig · Turkey |
| 2022-02-19 | JagielloniavCracoviaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-02-19 | NorthamptonvColchesterLeague Two · England | 3–0 | League Two · England |
| 2022-02-19 | Real MadridvAlavesLa Liga · Spain | 3–0 | La Liga · Spain |
| 2022-02-19 | ForfarvKelty HeartsLeague Two · Scotland | 1–0 | League Two · Scotland |
| 2022-02-19 | Aston VillavWatfordPremier League · England | 0–1 | Premier League · England |
| 2022-02-19 | West HamvNewcastlePremier League · England | 1–1 | Premier League · England |
| 2022-02-19 | CowdenbeathvElginLeague Two · Scotland | 2–0 | League Two · Scotland |
| 2022-02-19 | SochauxvAjaccioLigue 2 · France | 0–1 | Ligue 2 · France |
| 2022-02-19 | LiverpoolvNorwichPremier League · England | 3–1 | Premier League · England |
| 2022-02-19 | SunderlandvMilton Keynes DonsLeague One · England | 1–2 | League One · England |
| 2022-02-19 | GironavEibarLa Liga 2 · Spain | 0–1 | La Liga 2 · Spain |
| 2022-02-19 | NantesvParis SGLigue 1 · France | 3–1 | Ligue 1 · France |
| 2022-02-19 | MonzavPisaSerie B · Italy | 1–2 | Serie B · Italy |
| 2022-02-19 | Crystal PalacevChelseaPremier League · England | 0–1 | Premier League · England |
| 2022-02-19 | Gamba OsakavKashima AntlersJ1 League · Japan | 1–3 | J1 League · Japan |
| 2022-02-19 | IonikosvOFI CreteSuper League · Greece | 0–0 | Super League · Greece |
| 2022-02-19 | Queen of SthvArbroathChampionship · Scotland | 0–0 | Championship · Scotland |
| 2022-02-19 | AtromitosvAsteras TripolisSuper League · Greece | 2–0 | Super League · Greece |
| 2022-02-19 | Austria ViennavHartbergBundesliga · Austria | 2–0 | Bundesliga · Austria |