| 2022-02-19 | OldhamvBradfordLeague Two · England | 2–0 | League Two · England |
| 2022-02-19 | GuimaraesvAroucaPrimeira Liga · Portugal | 1–3 | Primeira Liga · Portugal |
| 2022-02-19 | VicenzavSpalSerie B · Italy | 1–1 | Serie B · Italy |
| 2022-02-19 | FC VoluntarivSepsi Sf. GheorgheSuperliga · Romania | 3–1 | Superliga · Romania |
| 2022-02-19 | BoltonvAFC WimbledonLeague One · England | 4–0 | League One · England |
| 2022-02-19 | Newport CountyvMansfieldLeague Two · England | 1–1 | League Two · England |
| 2022-02-19 | Termalica B-B.vLegiaEkstraklasa · Poland | 0–0 | Ekstraklasa · Poland |
| 2022-02-19 | QueretarovMazatlan FCLiga MX · Mexico | 2–0 | Liga MX · Mexico |
| 2022-02-19 | IpswichvBurtonLeague One · England | 3–0 | League One · England |
| 2022-02-19 | Sociedad BvMalagaLa Liga 2 · Spain | 2–0 | La Liga 2 · Spain |
| 2022-02-19 | CoventryvBarnsleyChampionship · England | 1–0 | Championship · England |
| 2022-02-19 | StevenagevBristol RvsLeague Two · England | 0–4 | League Two · England |
| 2022-02-19 | CardiffvBlackpoolChampionship · England | 1–1 | Championship · England |
| 2022-02-19 | Werder BremenvIngolstadt2. Bundesliga · Germany | 1–1 | 2. Bundesliga · Germany |
| 2022-02-19 | PueblavMonterreyLiga MX · Mexico | 1–0 | Liga MX · Mexico |
| 2022-02-19 | Nagoya GrampusvVissel KobeJ1 League · Japan | 2–0 | J1 League · Japan |
| 2022-02-19 | FulhamvHuddersfieldChampionship · England | 1–2 | Championship · England |
| 2022-02-19 | BrightonvBurnleyPremier League · England | 0–3 | Premier League · England |
| 2022-02-19 | NurnbergvRegensburg2. Bundesliga · Germany | 2–0 | 2. Bundesliga · Germany |
| 2022-02-19 | Gil VicentevBelenensesPrimeira Liga · Portugal | 2–0 | Primeira Liga · Portugal |
| 2022-02-19 | BastiavDijonLigue 2 · France | 0–0 | Ligue 2 · France |
| 2022-02-19 | OostendevStandardPro League · Belgium | 1–0 | Pro League · Belgium |
| 2022-02-19 | RodezvAmiensLigue 2 · France | 1–1 | Ligue 2 · France |
| 2022-02-19 | HartlepoolvSuttonLeague Two · England | 1–1 | League Two · England |
| 2022-02-19 | Inverness CvAyrChampionship · Scotland | 1–2 | Championship · Scotland |
| 2022-02-19 | LuganovSt. GallenSuper League · Switzerland | 0–2 | Super League · Switzerland |
| 2022-02-19 | MotherwellvAberdeenPremiership · Scotland | 1–1 | Premiership · Scotland |
| 2022-02-19 | NancyvDunkerqueLigue 2 · France | 2–0 | Ligue 2 · France |
| 2022-02-19 | CambridgevAccringtonLeague One · England | 2–0 | League One · England |
| 2022-02-19 | Sheffield UnitedvSwanseaChampionship · England | 4–0 | Championship · England |
| 2022-02-19 | St JohnstonevHeartsPremiership · Scotland | 2–1 | Premiership · Scotland |
| 2022-02-19 | RiedvTirolBundesliga · Austria | 3–2 | Bundesliga · Austria |
| 2022-02-19 | TranmerevPort ValeLeague Two · England | 1–1 | League Two · England |
| 2022-02-19 | BesiktasvAltaySüper Lig · Turkey | 1–0 | Süper Lig · Turkey |
| 2022-02-19 | CadizvGetafeLa Liga · Spain | 1–1 | La Liga · Spain |
| 2022-02-19 | TorquayvBarnetNational League · England | 2–2 | National League · England |
| 2022-02-19 | KayserisporvGiresunsporSüper Lig · Turkey | 2–1 | Süper Lig · Turkey |
| 2022-02-19 | DoncastervSheffield WedsLeague One · England | 1–3 | League One · England |
| 2022-02-19 | Man CityvTottenhamPremier League · England | 2–3 | Premier League · England |
| 2022-02-19 | Bristol CityvMiddlesbroughChampionship · England | 2–1 | Championship · England |
| 2022-02-19 | PrestonvReadingChampionship · England | 2–3 | Championship · England |
| 2022-02-19 | HamiltonvMortonChampionship · Scotland | 1–0 | Championship · Scotland |
| 2022-02-19 | AdmiravLASKBundesliga · Austria | 0–3 | Bundesliga · Austria |
| 2022-02-19 | PeterheadvAirdrie UtdLeague One · Scotland | 0–1 | League One · Scotland |
| 2022-02-19 | AscolivAlessandriaSerie B · Italy | 3–0 | Serie B · Italy |
| 2022-02-19 | NimesvGrenobleLigue 2 · France | 3–1 | Ligue 2 · France |
| 2022-02-19 | GranadavVillarrealLa Liga · Spain | 1–4 | La Liga · Spain |
| 2022-02-19 | WolfsburgvHoffenheimBundesliga · Germany | 1–2 | Bundesliga · Germany |
| 2022-02-19 | BaselvLausanneSuper League · Switzerland | 3–0 | Super League · Switzerland |
| 2022-02-19 | StokevBirminghamChampionship · England | 2–2 | Championship · England |